The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The role of mHealth for improving medication adherence in patients with cardiovascular disease: a systematic review
Open accessAbstract
Cardiovascular disease is a leading cause of morbidity and mortality worldwide, and a key barrier to improved outcomes is medication non-adherence. The aim of this study is to review the role of mobile health (mHealth) tools for improving medication adherence in patients with cardiovascular disease. We performed a systematic search for randomized controlled trials that primarily investigated mHealth tools for improving adherence to cardiovascular disease medications in patients with hypertension, coronary artery disease, heart failure, peripheral arterial disease, and stroke. We extracted and reviewed data on the types of mHealth tools used, preferences of patients and healthcare providers, the effect of the mHealth interventions on medication adherence, and the limitations of trials. We identified 10 completed trials matching our selection criteria, mostly with <100 participants, and ranging in duration from 1 to 18 months. mHealth tools included text messages, Bluetooth-enabled electronic pill boxes, online messaging platforms, and interactive voice calls. Patients and healthcare providers generally preferred mHealth to other interventions. All 10 studies reported that mHealth interventions improved medication adherence, though the magnitude of benefit was not consistently large and in one study was not greater than a telehealth comparator. Limitations of trials included small sample sizes, short duration of follow-up, self-reported outcomes, and insufficient assessment of unintended harms and financial implications. Current evidence suggests that mHealth tools can improve medication adherence in patients with cardiovascular diseases. However, high-quality clinical trials of sufficient size and duration are needed to move the field forward and justify use in routine care.
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“The effectiveness of digital health interventions on adherence to medication was reported in previous systematic reviews with an improvement in medication adherence and other health outcomes.59,61,62”
From Effectiveness of digital health interventions on blood pressure control, lifestyle behaviours and adherence to medication in patients with hypertension in low-income and middle-income countries: a systematic review and meta-analysis of randomised controlled trials (2024) · cites this paper as [61]
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Cites
Adherence to Long-Term Therapies: Evidence for Action
Geest, S. D., & Sabate, E. J. (2003) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(03)00091-4 · Cited by 6,310
Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence
Morisky, D. E., Green, L. W., & Levine, D. M. (1986) · Medical Care · doi:10.1097/00005650-198601000-00007 · Cited by 5,399
Impact of Medication Adherence on Hospitalization Risk and Healthcare Cost
Sokol, M. C., McGuigan, K. A., Verbrugge, R. R., & Epstein, R. S. (2005) · Medical Care · doi:10.1097/01.mlr.0000163641.86870.af · Cited by 1,729
Medication Adherence: Its Importance in Cardiovascular Outcomes
Ho, P. M., Bryson, C. L., & Rumsfeld, J. S. (2009) · Circulation · doi:10.1161/circulationaha.108.768986 · Cited by 1,488
Hamine, S., Gerth-Guyette, E., Faulx, D., Green, B. B., & Ginsburg, A. S. (2015) · Journal of Medical Internet Research · doi:10.2196/jmir.3951 · Cited by 1,149
Boulos, M. N. K., Wheeler, S., Tavares, C., & Jones, R. B. (2011) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-10-24 · Cited by 1,123
Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease: A Meta-analysis
Thakkar, J., Kurup, R., Laba, T.-L., Santo, K., Thiagalingam, A., Rodgers, A., Woodward, M., Redfern, J., & Chow, C. K. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.7667 · Cited by 685
The double burden of communicable and non-communicable diseases in developing countries
Boutayeb, A. (2005) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2005.07.021 · Cited by 680
Dias-Barbosa, C., Balp, Kulich, K. R., Germain, N., & Rofail, D. (2012) · Patient Preference and Adherence · doi:10.2147/ppa.s24752 · Cited by 549
Burke, L. E., Ma, J., Azar, K. M. J., Bennett, G. G., Peterson, E. D., Zheng, Y., Riley, W., Stephens, J., Shah, S. H., Suffoletto, B., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000232 · Cited by 516
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Davies, N., Davies, E. H., & Hughes, D. A. (2026) · British Journal of Clinical Pharmacology · doi:10.1002/bcp.70718
Metadata
- Authors
- Gandapur, Y., Kianoush, S., Kelli, H. M., Misra, S., Urrea, B., Blaha, M. J., Graham, G., Marvel, F. A., & Martin, S. S.
- Affiliations
- MedStar Union Memorial Hospital (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of Connecticut (US)
- Corresponding author
- Gandapur, Yousuf
- ORCID
- Venue
- European Heart Journal - Quality of Care and Clinical Outcomes
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-04-12
- Volume
- 2
- Issue
- 4
- Pages
- 237-244
- ISSN
- 2058-1742 (ISSN-L)
- 2058-5225
- PMC
- PMC5862021
- OpenAlex
- W2342277966
- Cited by
- 202
- References
- 38
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 28 · 2023: 29 · 2022: 29 · 2021: 29 · 2020: 23 · 2019: 17 · 2018: 9 · 2017: 10 · 2016: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- European Heart Journal - Quality of Care and Clinical Outcomes (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Health Professions › Health Information Management › Health, Technology, Consumer Behavior
- Keywords
- mobile health, medication adherence, cardiovascular disease, hypertension, coronary artery disease, heart failure, peripheral arterial disease, stroke, text messaging, telemedicine, patient preferences, healthcare provider preferences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Coronary Artery Disease, Female, Heart Failure, Humans, Hypertension, Male, Middle Aged, Randomized Controlled Trials as Topic, Drug Monitoring, Reminder Systems, Outcome Assessment, Health Care, Telemedicine, Stroke, Cell Phone, Peripheral Arterial Disease, Text Messaging
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