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Cited by 57Mobile Health and mHealth ApplicationsMedication Adherence and ComplianceHealth, Technology, Consumer Behavior

Effectiveness of mHealth Interventions in Medication Adherence among Patients with Cardiovascular Diseases: A Systematic Review

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Arshed, Muhammad, Mahmud, Aidalina Binti, Minhat, Halimatus Sakdiah, Ying, Lim Poh, Umer, Muhammad Farooq·2023·Diseases
DOI 10.3390/diseases11010041PMC PMC10047328
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Abstract

mHealth interventions have been reported to improve adherence to long-term therapies in chronic conditions. Therefore, this study aimed at determining the effectiveness of mHealth interventions in medication adherence among patients with cardiovascular diseases (CVDs), a leading cause of mortality globally. Relying on our inclusion criteria and the PRISMA recommendations, a literature search was carried out in the PubMed, Medline, and ProQuest databases for primary studies that investigated the impact of mHealth on medication adherence for cardiovascular disease (CVD) between 2000–2021. A total of 23 randomized controlled trials with 34,915 participants matched the selection criteria. The mHealth interventions used included text messages, mobile phone applications, and voice calls, which were used either as a single intervention or combined. Additionally, studies on enhancing drug adherence had contradictory findings: most of the studies elaborated positive results; however, six studies were unable to reveal any significant effect. Finally, a risk bias analysis revealed varying outcomes across all studies. This review, as a whole, supported the notion that mHealth interventions can be effective in improving adherence to CVD medication even though they could not improve adherence to all CVD medications when compared with controls. Further trials with more refined designs integrated with comprehensive interventions are needed to produce better health outcomes.

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  1. [1]Roth G.A. Johnson C. Abajobir A. Abd-Allah F. Abera S.F. Abyu G. Ahmed M. Aksut B. Alam T. Alam K. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 J. Am. Coll. Cardiol. 2017 70 1 25 10.1016/j.jacc.2017.04.052 28527533 PMC5491406 · DOI · Paper page
  2. [2]Abbafati C. Machado D.B. Cislaghi B. Salman O.M. Karanikolos M. McKee M. Abbas K.M. Brady O.J. Larson H.J. Trias-Llimós S. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019 Lancet 2020 396 1204 1222 33069326 PMC7567026
  3. [3]Mensah G.A. Roth G.A. Fuster V. The Global Burden of Cardiovascular Diseases and Risk Factors: 2020 and Beyond J. Am. Coll. Cardiol. 2019 74 2529 2532 10.1016/j.jacc.2019.10.009 31727292 · DOI
  4. [4]Zhu Z. Liu Y. Zhang C. Yuan Z. Zhang Q. Tang F. Lin H. Zhang Y. Liu L. Xue F. Identification of Cardiovascular Risk Components in Urban Chinese with Metabolic Syndrome and Application to Coronary Heart Disease Prediction: A Longitudinal Study. Han W, editor PLoS ONE 2013 8 e84204 10.1371/journal.pone.0084204 24358344 PMC3866125 · DOI
  5. [5]Peters S. Wang X. Lam T.H. Kim H.C. Suzanne Asia Pacific Cohort Studies Collaboration Ninomiya T. Knuiman M. Vaartjes I. Bots M.L. Woodward M. Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: Results from the Asia Pacific Cohort Studies Collaboration BMJ Open 2018 8 e019335 10.1136/bmjopen-2017-019335 29511013 PMC5855160 · DOI
  6. [6]Murray M. Murray L. Donnelly M. Systematic review protocol of interventions to improve the psychological well-being of general practitioners Syst. Rev. 2015 4 117 10.1186/s13643-015-0098-z 26394833 PMC4580348 · DOI
  7. [8]Kini V. Ho P.M. Interventions to Improve Medication Adherence: A Review JAMA. 2018 320 2461 2473 10.1001/jama.2018.19271 30561486 · DOI
  8. [9]Sieben A. Bredie S.J.H.B. van Laarhoven C.J.H.M.K. Schoonhoven L. Burger D.M. van Onzenoort H.A.W. e-Health interventions and improvement in treatment adherence Ned. Tijdschr. Geneeskd. 2014 158 A8460 25534266
  9. [10]Wilhelmsen N.C. Eriksson T. Medication adherence interventions and outcomes: An overview of systematic reviews Eur. J. Hosp. Pharm. Sci. Pract. 2019 26 187 192 10.1136/ejhpharm-2018-001725 31338165 PMC6613929 · DOI
  10. [11]Kolandaivelu K. Leiden B.B. O’Gara P.T. Bhatt D.L. Non-adherence to cardiovascular medications Eur. Heart J. 2014 35 3267 3276 10.1093/eurheartj/ehu364 25265973 · DOI
  11. [12]Kumar S. Nilsen W.J. Abernethy A. Atienza A. Patrick K. Pavel M. Riley W.T. Shar A. Spring B. Spruijt-Metz D. Mobile health technology evaluation: The mHealth evidence workshop Am. J. Prev. Med. 2013 45 228 236 10.1016/j.amepre.2013.03.017 23867031 PMC3803146 · DOI · Paper page
  12. [13]Burke L.E. Ma J. Azar K.M. Bennett G.G. Peterson E.D. Zheng Y. Riley W. Stephens J. Shah S.H. Suffoletto B. Current science on consumer use of mobile health for cardiovascular disease prevention: A scientific statement from the American Heart Association Circulation 2015 132 1157 1213 10.1161/CIR.0000000000000232 26271892 PMC7313380 · DOI · Paper page
  13. [14]Adler A.J. Martin N. Mariani J. Tajer C.D. Owolabi O.O. Free C. Serrano N.C. Casas J.P. Perel P. Mobile phone text messaging to improve medication adherence in secondary prevention of cardiovascular disease Cochrane Database Syst. Rev. 2017 4 CD011851 10.1002/14651858.CD011851.pub2 28455948 PMC6478182 · DOI
  14. [17]Park L.G. Howie-Esquivel J. Chung M.L. Dracup K. A text messaging intervention to promote medication adherence for patients with coronary heart disease: A randomized controlled trial Patient Educ. Couns. 2014 94 261 268 10.1016/j.pec.2013.10.027 24321403 · DOI
  15. [18]Wald D.S. Bestwick J.P. Raiman L. Brendell R. Wald N.J. Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial) PLoS ONE 2014 9 e114268 10.1371/journal.pone.0114268 25479285 PMC4257733 · DOI
  16. [19]Vollmer W.M. Owen-Smith A.A. O Tom J. Laws R. Ditmer D.G. Smith D.H. Waterbury A.C. Schneider J.L. Yonehara C.H. Williams A. Improving adherence to cardiovascular disease medications with information technology Am. J. Manag. Care 2014 20 SP502 25811824 PMC6358176
  17. [21]Ho P.M. Lambert-Kerzner A. Carey E.P. Fahdi I.E. Bryson C.L. Melnyk S.D. Bosworth H.B. Radcliff T. Davis R. Mun H. Multifaceted intervention to improve medication adherence and secondary prevention measures after acute coronary syndrome hospital discharge: A randomized clinical trial JAMA Intern. Med. 2014 174 186 193 10.1001/jamainternmed.2013.12944 24247275 · DOI
  18. [22]Khonsari S. Subramanian P. Chinna K. Latif L.A. Ling L.W. Gholami O. Effect of a reminder system using an automated short message service on medication adherence following acute coronary syndrome Eur. J. Cardiovasc. Nurs. 2015 14 170 179 10.1177/1474515114521910 24491349 · DOI · Paper page
  19. [24]Fang R. Li X. Electronic messaging support service programs improve adherence to lipid-lowering therapy among outpatients with coronary artery disease: An exploratory randomised control study J. Clin. Nurs. 2016 25 664 671 10.1111/jocn.12988 26522838 · DOI · Paper page
  20. [26]Maslakpak M.H. Safaie M. A Comparison between The Effectiveness of Short Message Service and Reminder Cards Regarding Medication Adherence in Patients with Hypertension: A Randomized Controlled Clinical Trial Int. J. Community Based Nurs. Midwifery 2016 4 209 27382587 PMC4926000
  21. [27]Kim J.Y. Wineinger N.E. Steinhubl S.R. The Influence of Wireless Self-Monitoring Program on the Relationship Between Patient Activation and Health Behaviors, Medication Adherence, and Blood Pressure Levels in Hypertensive Patients: A Substudy of a Randomized Controlled Trial J. Med. Internet Res. 2016 18 e116 10.2196/jmir.5429 27334418 PMC4935792 · DOI
  22. [28]Johnston N. Bodegard J. Jerström S. Åkesson J. Brorsson H. Alfredsson J. Albertsson P.A. Karlsson J.-E. Varenhorst C. Effects of interactive patient smartphone support app on drug adherence and lifestyle changes in myocardial infarction patients: A randomized study Am. Heart J. 2016 178 85 94 10.1016/j.ahj.2016.05.005 27502855 · DOI
  23. [29]Reddy A. Huseman T.L. Canamucio A. Marcus S.C. Asch D.A. Volpp K. Long J.A. Patient and Partner Feedback Reports to Improve Statin Medication Adherence: A Randomized Control Trial J. Gen. Intern. Med. 2017 32 256 261 10.1007/s11606-016-3858-0 27612487 PMC5330995 · DOI
  24. [30]Kamal A.K. Khalid W. Muqeet A. Jamil A. Farhat K. Gillani S.R.A. Zulfiqar M. Saif M. Muhammad A.A. Zaidi F. Making prescriptions “talk” to stroke and heart attack survivors to improve adherence: Results of a randomized clinical trial (The Talking Rx Study) PLoS ONE 2018 13 e0197671 10.1371/journal.pone.0197671 30571697 PMC6301764 · DOI
  25. [31]Ni Z. Liu C. Wu B. Yang Q. Douglas C. Shaw R.J. An mHealth intervention to improve medication adherence among patients with coronary heart disease in China: Development of an intervention Int. J. Nurs. Sci. 2018 5 322 330 10.1016/j.ijnss.2018.09.003 31406843 PMC6626280 · DOI
  26. [32]Kessler J.B. Troxel A.B. Asch D.A. Mehta S.J. Marcus N. Lim R. Zhu J. Shrank W. Brennan T. Volpp K.G. Partners and Alerts in Medication Adherence: A Randomized Clinical Trial J. Gen. Intern. Med. 2018 33 1536 1542 10.1007/s11606-018-4389-7 29546659 PMC6109000 · DOI
  27. [33]Morawski K. Ghazinouri R. Krumme A. Lauffenburger J.C. Lu Z. Durfee E. Oley L. Lee J. Mohta N. Haff N. Association of a Smartphone Application With Medication Adherence and Blood Pressure Control: The MedISAFE-BP Randomized Clinical Trial JAMA Intern. Med. 2018 178 802 809 10.1001/jamainternmed.2018.0447 29710289 PMC6145760 · DOI · Paper page
  28. [34]Santo K. Singleton A. Chow C.K. Redfern J. Evaluating Reach, Acceptability, Utility, and Engagement with An App-Based Intervention to Improve Medication Adherence in Patients with Coronary Heart Disease in the MedApp-CHD Study: A Mixed-Methods Evaluation Med. Sci. 2019 7 68 10.3390/medsci7060068 PMC6631463 31167489 · DOI
  29. [35]Desveaux L. Saragosa M. Russell K. McCleary N. Presseau J. Witteman H.O. Schwalm J.D. Ivers N.M. How and why a multifaceted intervention to improve adherence post-MI worked for some (and could work better for others): An outcome-driven qualitative process evaluation BMJ Open 2020 10 e036750 10.1136/bmjopen-2019-036750 32883724 PMC7473621 · DOI
  30. [36]Ivers N.M. Schwalm J.D. Bouck Z. McCready T. Taljaard M. Grace S.L. Cunningham J. Bosiak B. Presseau J. Witteman H.O. Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): Pragmatic randomised controlled trial BMJ 2020 369 m1731 10.1136/bmj.m1731 32522811 PMC7284284 · DOI
  31. [37]Zhai P. Hayat K. Ji W. Li Q. Shi L. Atif N. Xu S. Li P. Du Q. Fang Y. Efficacy of text messaging and personal consultation by pharmacy students among adults with hypertension: Randomized controlled trial J. Med. Internet Res. 2020 22 e16019 10.2196/16019 32432556 PMC7270845 · DOI
  32. [38]Maddison R. Jiang Y. Stewart R. Scott T. Kerr A. Whittaker R. Benatar J. Rolleston A. Estabrooks P. Dale L. An intervention to improve medication adherence in people with heart disease (text4heartii): Randomized controlled trial JMIR mHealth uHealth. 2021 9 e24952 10.2196/24952 34106081 PMC8262599 · DOI
  33. [39]Klimis H. Thakkar J. Chow C.K. Breaking Barriers: Mobile Health Interventions for Cardiovascular Disease Can. J. Cardiol. 2018 34 905 913 10.1016/j.cjca.2018.02.012 29887218 · DOI · Paper page
  34. [40]Andre N. Wibawanti R. Siswanto B.B. Mobile Phone-Based Intervention in Hypertension Management Int. J. Hypertens. 2019 2019 9021017 10.1155/2019/9021017 31080670 PMC6475551 · DOI
  35. [42]Bond Z. Scanlon T. Judah G. Systematic Review of RCTs Assessing the Effectiveness of mHealth Interventions to Improve Statin Medication Adherence: Using the Behaviour-Change Technique Taxonomy to Identify the Techniques That Improve Adherence Healthcare 2021 9 1282 10.3390/healthcare9101282 34682962 PMC8535703 · DOI
  36. [43]Gandhi S. Chen S. Hong L. Sun K. Gong E. Li C. Yan L.L. Schwalm J.-D. Effect of Mobile Health Interventions on the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis Can. J. Cardiol. 2017 33 219 231 10.1016/j.cjca.2016.08.017 27956043 · DOI
  37. [44]Thakkar J. Kurup R. Laba T.L. Santo K. Thiagalingam A. Rodgers A. Woodward M. Redfern J. Chow C.K. Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease: A Meta-analysis JAMA Intern Med. 2016 176 340 349 10.1001/jamainternmed.2015.7667 26831740 · DOI · Paper page
  38. [45]Al-Arkee S. Mason J. A Lane D. Fabritz L. Chua W. Haque M.S. Jalal Z. Mobile Apps to Improve Medication Adherence in Cardiovascular Disease: Systematic Review and Meta-analysis J. Med. Internet Res. 2021 23 e24190 10.2196/24190 34032583 PMC8188316 · DOI
  39. [46]Kassavou A. Sutton S. Automated telecommunication interventions to promote adherence to cardio-metabolic medications: Meta-analysis of effectiveness and meta-regression of behaviour change techniques Health Psychol. Rev. 2018 12 25 42 10.1080/17437199.2017.1365617 28805162 · DOI
  40. [47]Pfaeffli Dale L. Dobson R. Whittaker R. Maddison R. The effectiveness of mobile-health behaviour change interventions for cardiovascular disease self-management: A systematic review Eur. J. Prev. Cardiol. 2016 23 801 817 10.1177/2047487315613462 26490093 · DOI
  41. [48]van Driel M.L. Morledge M.D. Ulep R. Shaffer J.P. Davies P. Deichmann R. Interventions to improve adherence to lipid-lowering medication Cochrane Database Syst. Rev. 2016 12 CD004371 28000212 PMC6464006
  42. [49]Thirumurthy H. Jakubowski A. Camlin C. Kabami J. Ssemmondo E. Elly A. Mwai D. Clark T. Cohen C. Bukusi E. Expectations about future health and longevity in Kenyan and Ugandan communities receiving a universal test-and-treat intervention in the SEARCH trial AIDS Care 2016 28 (Suppl. S3) 90 98 10.1080/09540121.2016.1178959 27421056 PMC5443252 · DOI
  43. [50]Sailer F. Pobiruchin M. Wiesner M. Meixner G. An Approach to Improve Medication Adherence by Smart Watches Digital Healthcare Empowering Europeans MIE IOS Press Amsterdam, The Netherlands 2015
  44. [51]Keil A. Gegier K. Pobiruchin M. Wiesner M. A Smartwatch-Driven Medication Management System Compliant to the German Medication Plan Stud. Health Technol. Inform. 2016 228 185 189 27577368
  45. [52]Wang H. Naghavi M. Allen C. Barber R. Bhutta Z. Carter A. Casey D. Charlson F. Chen A.Z. Coates M. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: A systematic analysis for the Global Burden of Disease Study 2015 Lancet 2016 388 1459 1544 Available online: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31012-1/abstract#.WtGaUq8NnO4.mendeley (accessed on 13 October 2022) 10.1016/S0140-6736(16)31012-1 27733281 PMC5388903 · DOI · Paper page

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Authors
Arshed, M., Mahmud, A. B., Minhat, H. S., Ying, L. P., & Umer, M. F.
Affiliations
  • Universiti Putra Malaysia (MY)
  • Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang 43400, Selangor Darul Ehsan, Malaysia
  • King Faisal University (SA)
Corresponding author
Umer, Muhammad Farooq
ORCID
Venue
Diseases
Publisher
MDPI AG
Published
2023-03-01
Volume
11
Issue
1
Pages
41
ISSN
2079-9721 (ISSN-L)
DOI
10.3390/diseases11010041
PMC
PMC10047328
OpenAlex
W4322774985
Cited by
57
References
7
Citations by year
2026: 19 · 2025: 14 · 2024: 17 · 2023: 7
FWCI
2.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Diseases (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Health Professions › Health Information Management › Health, Technology, Consumer Behavior
Keywords
mobile health intervention, medication adherence, cardiovascular disease, text messaging, mobile health apps, voice calls, chronic disease management

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