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Activation of the Drosophila NF‐κB factor Relish by rapid endoproteolytic cleavage
Open accessAbstract
The Rel/NF‐κB transcription factor Relish plays a key role in the humoral immune response in Drosophila . We now find that activation of this innate immune response is preceded by rapid proteolytic cleavage of Relish into two parts. An N‐terminal fragment, containing the DNA‐binding Rel homology domain, translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably to the promoters of other antimicrobial peptide genes. The C‐terminal IκB‐like fragment remains in the cytoplasm. This endoproteolytic cleavage does not involve the proteasome, requires the DREDD caspase, and is different from previously described mechanisms for Rel factor activation.
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Citations
Cited by
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
Georgel, P., Naitza, S., Kappler, C., Ferrandon, D., Zachary, D., Swimmer, C., Kopczynski, C., Duyk, G., Reichhart, J.-M., & Hoffmann, J. A. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00059-4 · Cited by 448
The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection
Leulier, F., Rodriguez, A., Khush, R. S., Abrams, J. M., & Lemaitre, B. (2000) · EMBO reports · doi:10.1093/embo-reports/kvd073 · Cited by 409
Metadata
- Authors
- Stöven, S., Ando, I., Kadalayil, L., Engström, Y., & Hultmark, D.
- Venue
- EMBO reports
- Published
- 2000-10
- Volume
- 1
- Issue
- 4
- Pages
- 347-352
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2048869977
- Cited by
- 338
- References
- 0
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stöven, S., Ando, I., Kadalayil, L., Engström, Y., & Hultmark, D. (2000). Activation of the Drosophila NF‐κB factor Relish by rapid endoproteolytic cleavage. EMBO reports. https://doi.org/10.1093/embo-reports/kvd072
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