The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection
Open accessAbstract
The Drosophila innate immune system discriminates between pathogens and responds by inducing the expression of specific antimicrobial peptide‐encoding genes through distinct signaling cascades. Fungal infection activates NF‐κB‐like transcription factors via the Toll pathway, which also regulates innate immune responses in mammals. The pathways that mediate antibacterial defenses, however, are less defined. We have isolated loss‐of‐function mutations in the caspase encoding gene dredd , which block the expression of all genes that code for peptides with antibacterial activity. These mutations also render flies highly susceptible to infection by Gram‐negative bacteria. Our results demonstrate that Dredd regulates antibacterial peptide gene expression, and we propose that Dredd, Immune Deficiency and the P105‐like rel protein Relish define a pathway that is required to resist Gram‐negative bacterial infections.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.-M., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,043
Self-citationTakeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,362
Lemaitre, B., Reichhart, J.-M., & Hoffmann, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14614 · Cited by 1,034
Self-citationTlr4: central component of the sole mammalian LPS sensor
Beutler, B. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00046-1 · Cited by 762
Lemaitre, B., Kromer-Metzger, E., Michaut, L., Nicolas, E., Meister, M., Georgel, P., Reichhart, J. M., & Hoffmann, J. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9465 · Cited by 646
Self-citationToll signaling pathways in the innate immune response
Anderson, K. V. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00045-x · Cited by 632
Relish, a Central Factor in the Control of Humoral but Not Cellular Immunity in Drosophila
Hedengren, M., BengtÅsling, Dushay, M. S., Ando, I., Ekengren, S., Wihlborg, M., & Hultmark, D. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80392-5 · Cited by 540
Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.
Dushay, M. S., Asling, B., & Hultmark, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10343 · Cited by 373
The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila
Rutschmann, S., Jung, A. C., Hetru, C., Reichhart, J.-M., Hoffmann, J. A., & Ferrandon, D. (2000) · Immunity · doi:10.1016/s1074-7613(00)80208-3 · Cited by 368
Activation of the Drosophila NF‐κB factor Relish by rapid endoproteolytic cleavage
Stöven, S., Ando, I., Kadalayil, L., Engström, Y., & Hultmark, D. (2000) · EMBO reports · doi:10.1093/embo-reports/kvd072 · Cited by 338
Cited by
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
The Drosophila Toll Signaling Pathway
Valanne, S., Wang, J.-H., & Rämet, M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002302 · Cited by 894
Metadata
- Authors
- Leulier, F., Rodriguez, A., Khush, R. S., Abrams, J. M., & Lemaitre, B.
- Venue
- EMBO reports
- Published
- 2000-10
- Volume
- 1
- Issue
- 4
- Pages
- 353-358
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2133375947
- Cited by
- 409
- References
- 21
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection. https://app.cochat.ai/papers/10.1093/embo-reports/kvd073
- The paper
- Leulier, F., Rodriguez, A., Khush, R. S., Abrams, J. M., & Lemaitre, B. (2000). The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection. EMBO reports. https://doi.org/10.1093/embo-reports/kvd073
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
