The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1
Open accessAbstract
We have recently shown that heterochromatin protein 1 (HP1) interacts with the nuclear envelope in an acetylation‐dependent manner. Using purified components and in vitro assays, we now demonstrate that HP1 forms a quaternary complex with the inner nuclear membrane protein LBR and a sub‐set of core histones. This complex involves histone H3/H4 oligomers, which mediate binding of LBR to HP1 and cross‐link these two proteins that do not interact directly with each other. Consistent with previous observations, HP1 and LBR binding to core histones is strongly inhibited when H3/H4 are modified by recombinant CREB‐binding protein, revealing a new mechanism for anchoring domains of under‐acetylated chromatin to the inner nuclear membrane.
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Cites
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845
Cited by
Somech, R., Shaklai, S., Geller, O., Amariglio, N., Simon, A. J., Rechavi, G., & Gal-Yam, E. N. (2005) · Journal of Cell Science · doi:10.1242/jcs.02521 · Cited by 223
Spatial chromatin organization and gene regulation at the nuclear lamina
Guerreiro, I., & Kind, J. (2019) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2019.04.008 · Cited by 59
Metadata
- Authors
- Polioudaki, H., Kourmouli, N., Drosou, V., Bakou, A., Theodoropoulos, P. A., Singh, P. B., Giannakouros, T., & Georgatos, S. D.
- Venue
- EMBO reports
- Published
- 2001-10
- Volume
- 2
- Issue
- 10
- Pages
- 920-925
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2118740910
- Cited by
- 179
- References
- 2
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Polioudaki, H., Kourmouli, N., Drosou, V., Bakou, A., Theodoropoulos, P. A., Singh, P. B., Giannakouros, T., & Georgatos, S. D. (2001). Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1. EMBO reports. https://doi.org/10.1093/embo-reports/kve199
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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