The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Genome‐wide analysis of mRNAs targeted to yeast mitochondria
Open accessAbstract
It is agreed that nuclear‐encoded mitochondrial proteins are post‐translationally targeted to mitochondria, even if, in some cases, a co‐translational phase can assist the import of precursor proteins. We used yeast DNA microarrays to analyse the mRNA populations associated with free and mitochondrion‐bound polysomes. As expected, many mRNAs, known to encode mitochondrial proteins, are localized to free cytoplasmic polysomes, but many are localized to mitochondrion‐bound polysomes. Furthermore, the 3′‐UTR of six randomly chosen mitochondrion‐bound mRNAs contains sufficient information to target, in vivo , non‐translatable RNA to the vicinity of mitochondria. Interestingly, genes producing mRNAs that are targeted to mitochondria are mainly of ancient bacterial origin, whereas those producing mRNAs that are translated in the cytoplasm are mainly of eukaryotic origin. These observations, which support the recent hypotheses concerning the dual origin of the mitochondrial proteome, provide new insights into the biogenesis of mitochondria.
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Cited by
Mootha, V. K., Bunkenborg, J., Olsen, J. V., Hjerrild, M., Wisniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00926-7 · Cited by 889
A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease
Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758
Mitochondrial protein import: from proteomics to functional mechanisms
Schmidt, O., Pfanner, N., & Meisinger, C. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2959 · Cited by 717
Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae
Arava, Y., Wang, Y., Storey, J. D., Liu, C. L., Brown, P. O., & Herschlag, D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0635171100 · Cited by 663
A high-resolution map of transcription in the yeast genome
David, L., Huber, W., Granovskaia, M., Toedling, J., Palm, C. J., Bofkin, L., Jones, T., Davis, R. W., & Steinmetz, L. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601091103 · Cited by 697
Metadata
- Authors
- Marc, P., Margeot, A., Devaux, F., Blugeon, C., Corral‐Debrinski, M., & Jacq, C.
- Venue
- EMBO reports
- Published
- 2002-02
- Volume
- 3
- Issue
- 2
- Pages
- 159-164
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2044895959
- Cited by
- 317
- References
- 35
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
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