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A γ‐secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
Open accessAbstract
Inhibition of amyloid beta-peptide (Abeta) production by blocking gamma-secretase activity is at present one of the most promising therapeutic strategies to slow progression of Alzheimer's disease pathology. gamma-secretase inhibitors apparently block Abeta generation via interference with presenilin (PS) function. Besides being an essential component of the gamma-secretase complex, PS itself may be an aspartyl protease with gamma-secretase activity, which is not only required for Abeta production but also for a similar proteolytic process involved in Notch signaling. Here we demonstrate that treatment of zebrafish embryos with a known gamma-secretase inhibitor affects embryonic development in a manner indistinguishable from Notch signaling deficiencies at morphological, molecular and biochemical levels. This indicates severe side-effects of gamma-secretase inhibitors in any Notch-dependent cell fate decision and demonstrates that the zebrafish is an ideal vertebrate system to validate compounds that selectively affect Abeta production, but not Notch signaling, under in vivo conditions.
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“DAPT, which prevents Notch cleavage and subsequent signaling by its intracellular domain, NICD”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Geling et al., 2002
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Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100
Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., & Selkoe, D. J. (1999) · Nature · doi:10.1038/19077 · Cited by 1,959
Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757
Self-citationNotch-1 signalling requires ligand-induced proteolytic release of intracellular domain
Schroeter, E. H., Kisslinger, J. A., & Kopan, R. (1998) · Nature · doi:10.1038/30756 · Cited by 1,624
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
Nilsberth, C., Westlind-Danielsson, A., Eckman, C. B., Condron, M. M., Axelman, K., Forsell, C., Stenh, C., Luthman, J., Teplow, D. B., Younkin, S. G., et al. (2001) · Nature Neuroscience · doi:10.1038/nn0901-887 · Cited by 1,209
Amyloid β-Protein Fibrillogenesis
Walsh, D. M., Lomakin, A., Benedek, G. B., Condron, M. M., & Teplow, D. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22364 · Cited by 1,156
Notch Signaling: From the Outside In
Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 964
Thisse, C., Thisse, B., Schilling, T. F., & Postlethwait, J. H. (1993) · Development · doi:10.1242/dev.119.4.1203 · Cited by 877
Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., Andrieu, P. D. S. I., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E. G., Holsztynska, E. J., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00012.x · Cited by 870
Cited by
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Duan, L., Jiang, Y., & Fong, G. (2024) · Development · doi:10.1242/dev.202802 · Cited by 7
Kotova, M. M., Stewart, A., Grigoryan, A., Shariff, S., Mirzaei, F., Kantawala, B., Dilbaryan, K., de Abreu, M. S., Galstryan, D. S., Cui, J., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70090 · Cited by 7
Journot, R. P., Huyghe, M., Barthelemy, A., Couto-Moreira, H., Deshayes, T., Harari, L., Sumbal, J., Faraldo, M. M., Dubail, M., Fouillade, C., et al. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.06.007 · Cited by 7
Nteliopoulos, G., & Gordon, M. Y. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0467 · Cited by 7
Tischfield, D. J., Kim, J., & Anderson, S. A. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.015 · Cited by 9
“…inhibitor DAPT ((S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido) propanamido)-2-phenylacetate), which inhibits Notch signaling by blocking cleavage of the Notch intracellular domain (Dovey et al., 2001; Geling et al., 2002), to our stem cell cultures from DD12 to DD14 (Figure 4A).”
BackgroundHuang, S.-C., Vu, L. V., Yu, F. H., Nguyen, D. T., & Benz, E. J. J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101051 · Cited by 7
“We examined the effect of Notch inhibition on cleaved Notch1, Hes1, and Numb expression in uninduced MELC.”
BackgroundInfluentialRihel, J., & Ghosh, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-05392-9_135 · Cited by 8
Chen, Y., & Behnisch, T. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.08.056 · Cited by 7
Takata, H., & Kominami, T. (2011) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2011.01278.x · Cited by 7
“To determine if Notch signaling is involved in the specification of these fluorescent cells, embryos were treated with N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester (DAPT), an inhibitor of gamma-secretase (Geling et al. 2002).”
MethodA Hes1‐based oscillator in cultured cells and its potential implications for the segmentation clock
Dale, J. K., & Maroto, M. (2003) · BioEssays · doi:10.1002/bies.10253 · Cited by 7
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Sande, R., Godad, A. P., & Doshi, G. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328279684240104094257 · Cited by 6
Shea, G. K., Tai, E. W., Leung, K. H., Mung, K. L., Li, M. T., Tsui, A. Y. P., Tam, A. K., Shum, D. K., & Chan, Y. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14837 · Cited by 6
Alunni, A., Coolen, M., Foucher, I., & Bally‐Cuif, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00026-6 · Cited by 6
Self-citationAltbürger, C., Rath, M., Armbruster, D., & Driever, W. (2023) · Developmental Biology · doi:10.1016/j.ydbio.2023.10.005 · Cited by 6
Wei, L., Oustah, A. A., Blader, P., & Roussigné, M. (2019) · eLife · doi:10.7554/elife.46275 · Cited by 6
“…complex, to block Notch signaling pathway during different time windows (Romero-Carvajal et al., 2015; Rothenaigner et al., 2011); γ-secretase activity is required for the release of the intracellular domain of Notch, NICD, during activation of the canonical pathway (Geling et al., 2002).”
BackgroundChong, M., Liao, M., & Drapeau, P. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20671 · Cited by 6
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Haffner, C., & Haass, C. (2004) · Neurodegenerative Diseases · doi:10.1159/000080985 · Cited by 7
Self-citationBos, T. A., Polyakova, E., van Gils, J. M., de Vries, A. A. F., Goumans, M., Freund, C. M. A. H., DeRuiter, M. C., & Jongbloed, M. R. M. (2025) · eLife · doi:10.7554/elife.103728 · Cited by 6
“Addition of two other small molecules (DAPT, an indirect Notch signaling inhibitor; Geling et al., 2002 ), and SU5402, an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and vascular endothelial growth factor receptor 2 (VEGFR2) ( Mohammadi et al., 1997 ), slightly increases the proportion…”
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Guerin, D. J., Gutierrez, B., Zhang, B., & Tseng, K. A.-S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062637 · Cited by 4
Development of the Primary Nervous System of the Zebrafish Embryo
Strähle, U., & Korzh, V. P. (2004) · Molecular aspects of fish and marine biology · doi:10.1142/9789812565761_0006 · Cited by 5
Interference Potential of Tannins and Chlorophylls in Zebrafish Phenotypic-Based Assays
Samat, N., Ng, M. F., Ruslan, N. F., Okuda, K. S., Tan, P. J., & Patel, V. (2018) · Assay and Drug Development Technologies · doi:10.1089/adt.2017.833 · Cited by 5
“16,38,39 Inhibitors of these pathways were chosen as previous screening efforts conducted in our laboratory and by others have utilized a developing zebrafish embryo phenotypic abnormality (curved trunk or lack of pigmentation phenotype) indicating inhibition of signal transduction as a way to…”
Ghosh, A., & Surolia, A. (2011) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.1118101 · Cited by 5
Design of ß-Secretase Inhibitors by Introduction of a Mandelyl Moiety in DAPT Analogues
Pietrancosta, N., Quéléver, G., Laras, Y., Garino, C., Burlet, S., & Kraus, J. L. (2005) · Australian Journal of Chemistry · doi:10.1071/ch05102 · Cited by 5
Pituitary Regeneration: It'll Knock Your SOX Off!
Ellsworth, B. S. (2016) · Endocrinology · doi:10.1210/en.2015-2059 · Cited by 4
Newman, M., Halter, L., Lim, A., & Lardelli, M. T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179859 · Cited by 4
Ravichandran, R., Wilson, D. D., Viswanathan, S., SiddikUzzaman, B. S. P., Bonati, L., Rajendran, S., & Grace, V. M. B. (2023) · Letters in Drug Design & Discovery · doi:10.2174/1570180820666230831095954 · Cited by 3
A Question of Origins: Non-neuronal Sources of Amyloid-β
Sasmita, A. O., & Depp, C. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-025-01572-4 · Cited by 4
“Meanwhile, a γ-secretase inhibitor was shown to block Notch signaling [41], potentially affecting cell fate in molecular circuits.”
Cotellessa, L., Marelli, F., Duminuco, P., Adamo, M., Papadakis, G. E., Bartoloni, L., Sato, N. S., Lang‐Muritano, M., Troendle, A., Dhillo, W. S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.161998 · Cited by 5
“The impact of Jag1/Notch signaling on GnRH3 neuronal development was further assessed by treating the tg(GnRH3:EGFP) embryos with the γ-secretase inhibitor DAPT, a well-known Notch inhibitor (41).”
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Steichele, M., Sauermann, L., Pan, Q., Moneer, J., de la Porte, A., Heß, M., Mercker, M., Strube, C., Flaswinkel, H., Jenewein, M., et al. (2024) · Life Science Alliance · doi:10.26508/lsa.202403054 · Cited by 3
Using Zebrafish to Study Multiciliated Cell Development and Disease States
Nguyen, T. K., Baker, S., Rodriguez, J.-M., Arceri, L., & Wingert, R. A. (2024) · Cells · doi:10.3390/cells13211749 · Cited by 3
“Gmnc expression was also highly expressed in one-month old zebrafish at locations with high MCC population in the brain, such as the anterior forebrain ChP and TC. Intriguingly, gmnc mutants at the adult stage displayed an absence of MCCs compared to WT [140].”
ResultWei, Z., Liu, C., Chen, J., Yao, Y., & Qin, D. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70015 · Cited by 3
Breunig, J. J., & Nelson, B. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00013-8 · Cited by 2
Alunni, A., Coolen, M., Foucher, I., & Bally‐Cuif, L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397265-1.00069-1 · Cited by 5
Self-citationAutomated Quantitation of Zebrafish Somites in High-Throughput Screens
Lu, J., Liu, T., Nie, J., Ding, J., Zhu, J., Yang, J., Guo, L., Xia, W., & Wong, S. T. C. (2006) · IEEE/NIH Life Science Systems and Applications Workshop · doi:10.1109/lssa.2006.250389 · Cited by 3
Schwayer, C., Barbiero, S., Brückner, D. B., Oost, K. C., Baader, C., Repina, N. A., Kim, J., Diaz, O. E., Uccelli, I., Capolupo, L., et al. (2026) · Cell · doi:10.1016/j.cell.2026.06.009 · Cited by 3
Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease
Hurst, T. P., Coleman-Vaughan, C., Patwal, I., & McCarthy, J. V. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.2.138 · Cited by 2
HES1 potentiates high salt stress response as an enhancer of NFAT5-DNA binding
Ryuno, H., Hanafusa, Y., Fujisawa, T., Ogawa, M., Adachi, H., Naguro, I., & Ichijo, H. (2024) · Communications Biology · doi:10.1038/s42003-024-06997-7 · Cited by 2
Rihel, J., & Ghosh, M. (2015) · Springer eBooks · doi:10.1007/978-3-642-27728-3_135-1 · Cited by 2
Delta/Notch signaling controls neuroepithelial morphogenesis in the zebrafish spinal cordPreprint
Sharma, P., Saraswathy, V. M., Xiang, L., & Fürthauer, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/517714 · Cited by 2
Bruton, F. A., Kaveh, A., Stewart, K. R., Matrone, G., Oremek, M. E. M., Solomonidis, E. G., Tucker, C. S., Mullins, J. J., Brittan, M., Taylor, J. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.15.448575 · Cited by 2
Avian Somitogenesis: Translating Time and Space into Pattern
Brand‐Saberi, B., Rudloff, S., & Gamel, A. J. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09606-3_2 · Cited by 1
Breunig, J. J., & Nelson, B. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397265-1.00070-8 · Cited by 1
“Alternatively, recent development of small molecules selectively targeting the gamma-secretase complex, such as DAPT, which rapidly inactivates its proteolytic activity and phenocopies Notch pathway mutations across multiple vertebrate and invertebrate neurogenic model systems (Geling et al., 2002; Micchelli et al., 2…”
BackgroundGeminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling
Huang, W., Zhang, Y., Cao, K., Luo, L., & Huang, S. (2018) · BioMed Research International · doi:10.1155/2018/6543196 · Cited by 1
“Although this result was not consistent with observations in DAPT-treated embryos [50], it could be explained indirectly by some earlier studies.”
MethodInfluentialEl‐Sehemy, A. (2014) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3mt2g · Cited by 1
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Foster, S., Oulhen, N., Fresques, T., Zaki, H., & Wessel, G. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.04.479164 · Cited by 1
“To test whether Delta/Notch may regulate germ cell factor gene expression in the sea star, we treated two-day old embryos with the Delta/Notch signaling inhibitor, DAPT [38].”
MethodInfluentialSteichele, M., Sauermann, L., Pan, Q., Moneer, J., de la Porte, A., Heß, M., Mercker, M., Strube, C., Flaswinkel, H., Jenewein, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.02.578611 · Cited by 1
Pérez-Dones, D., Ledesma-Terrón, M., Mazo-Durán, D., Navarro-Martinez, G., & Míguez, D. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.09.588672 · Cited by 1
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Sur, A., Segal, E. X., Nunneley, M. P., Sinclair, J. W., Prochaska, M. K., Dye, L., Wu, Y., FU, L., Yun-Bo, S., Iben, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.17.694935 · Cited by 1
Sur, A., Segal, E. X., Nunneley, M. P., Sinclair, J. W., Prochaska, M. K., Dye, L., Wu, Y., FU, L., Shi, Y., Iben, J., et al. (2026) · Genes & Development · doi:10.1101/gad.353662.126 · Cited by 1
Yang, H. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
Identification of Arterial Phenotype in Endothelial Cells Derived From Human Pluripotent Stem Cells
Lepley, M. A. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
The Dual Role of Notch Signaling During Motor Neuron Differentiation
Tan, G. C. (2012) · Columbia Academic Commons (Columbia University) · doi:10.7916/d8n01dmb
“To determine whether inhibition of Notch signaling can be used to increase efficiency of motor neuron differentiation in other cell lines, we examined the effects of treating differentiating cells with DAPT, a small molecule that inhibits Notch signaling by interfering with the formation of the gamma-secretase complex…”
BackgroundBatts, S. A. (2009) · Deep Blue (University of Michigan)
Novel insights into Flt1 mediated sprouting angiogenesis in zebrafish
Krueger, J. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-14034
γ-Secretase Mediated Proteolysis: At the Cutting Edge of Notch Signaling
Ilagan, M. X. G., Chandu, D., & Kopan, R. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6311-4_7
Dettmer, U. (2010) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.11933
Molecular and Morphological Characterization of Segmentation in Artemia franciscana
Blachuta, B. J. (2009) · UA Campus Repository (The University of Arizona)
Chapter 3 Stem Cells in Immortal Hydra
Bosch, T. C. G. (2008)
Network in Zebrafish Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic
Carmeliet, P., Dewerchin, M. A., Langenberg, T., Lawson, N. D., Duckers, H. J., Schulte‐Merker, S., Noël, A., Foidart, J.-M., Gerhardt, H., Mazzone, M., et al. (2012)
Applications of CRISPR-Cas systems in neuroscience
Harvard, C. (2016)
Development of Specific Gamma Secretase Inhibitors
Ahmed, J. (2009) · IGI Global eBooks · doi:10.4018/978-1-60566-076-9.ch025
Fritz, A. E. (2014) · KU ScholarWorks (The University of Kansas)
The Role of the Notch Signaling Pathway during Postembryonic Retinal Neurogenesis in Danio rerio
Chiang, R. Y. (2015) · TSpace (University of Toronto)
Integrated Genomic and Epigenomic Analyses of Atypical Teratoid Rhabdoid Tumour
Torchia, J. (2016) · TSpace (University of Toronto)
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Shono, T., Thiery, A. P., Cooper, R. L., Kurokawa, D., Britz, R., Okabe, M., & Fraser, G. J. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3362261
Bruton, F. A., Kaveh, A., Stewart, K. R., Matrone, G., Oremek, M. E. M., Solomonidis, E. G., Tucker, C. S., Mullins, J. J., Brittan, M., Taylor, J. M., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3904965
Khalil, S. I. (2015) · Trinity College Digital Repository (Trinity College, Hartford CT)
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Ryuno, H., Hanafusa, Y., Naguro, I., & Ichijo, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.10.511678
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Nian, F., Liao, B., Su, Y., Wu, P., Tsai, J., & Hou, P. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04530-9
Hossain, M. S., Amin, M. A., Sakib, M. S. A., Akter, A., Das, L. C., Islam, M. N., & Rahman, M. M. (2024) · Research Square · doi:10.21203/rs.3.rs-5369025/v1
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Feng, S., Qu, R., He, Y., Huang, T., Wang, Y., Trinh, T. H., Cheng, K., Zhao, S., Huang, Y. K., Zhu, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.20.655066
Vaparanta, K. M., Song, Z., Farahani, I. K., Jokilammi, A., Merilahti, J. A. M., Örling, J., Virtanen, N., Haapaniemi, P., Sahlgren, C., Elenius, K., et al. (2025) · FEBS Journal · doi:10.1111/febs.70197
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Campos, O. A., Migliara, A., Wasinger, S. R., Chen, Z., Grant, Z. L., Lopez, P., Bruneau, B. G., Toda, S., Lim, W. A., & Almeida, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.29.679324 · Cited by 1
Szabó, N., Fodor, E., Szabó, K. S., Tarcsa, V., Gyulai, Z., Jakab, S., Gelei, E., Czimer, D., Miklósi, Á., & Varga, M. (2025) · Biologia Futura · doi:10.1007/s42977-025-00290-2
“The application of the Notch inhibitor DAPT (100 μM) was shown to result in similar phenotypes to those observed in the mutants of the Notch/Delta signaling pathways in zebrafish and leads to disruptions of somite formation (Arslanova et al. 2010; Geling et al. 2002).”
Gomes, C. D. S., Souza, J. A. D. C. R., de Sousa, N. F., Maia, M. D. S., Martins, R. X., Scotti, M. T., & Farias, D. F. (2025) · Ecotoxicology · doi:10.1007/s10646-025-02984-8
“Moreover, Geling et al. (2002 ) demonstrated that inhibiting γ-secretase in zebrafish embryos disrupts Notch signaling, consequently inducing somitogenic and neurogenic defects.”
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Boeras, D. I. (2005) · Digital Commons - University of South Florida (University of South Florida)
Dai, W. (2011) · Deep Blue (University of Michigan)
Sundvik, M. (2012) · Työväentutkimus Vuosikirja
The role of HEB and E2A in the regulation of T Lymphocyte development and proliferation
Wojciechowski, J. (2007) · DukeSpace (Duke University)
Control of early human lymphoid development
Schotte, R. (2007) · Data Archiving and Networked Services (DANS)
Chrysostomou, E. (2012) · Doctoral thesis, UCL (University College London).
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Steiner, H., & Haass, C. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6311-4_3
Self-citationRégulation du développement des cellules musculaires lisses de l'estomac chez l'embryon de poulet
McKey, J. (2014) · theses.fr (ABES) · doi:10.70675/2abfa796za204z42ffz97abz7375af675e4a
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Perrier, A. (2023) · theses.fr (ABES) · doi:10.70675/ea490599zc7fcz4bcazb01dz83e591b2fab5
Moghadam, H. K., Yoshida, G., Fannemel, B., Houston, R. D., & Thorland, I. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.744087
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Santiago, Á., Melendez-Martinez, D., Aguayo‐Ortiz, R., & Domı́nguez, L. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00080
Hossain, M. S., Amin, M. A., Akter, A., Dutta, A., Sakib, M. S. A., Das, L. C., Islam, M. N., & Rahman, M. M. (2026) · Heliyon · doi:10.1016/j.heliyon.2026.e45453
Murata, K., Mizushina, Y., Izawa, D., Matsui, Y., Wakabayashi, T., Hashimoto, T., Iwatsubo, T., & Matsushima, Y. (2026) · Planta Medica · doi:10.1055/a-2943-8874
“19 Classical γ -secretase inhibitors, such as DAPT, suppress Notch signaling but also cause CTF β accumulation owing to reduced γ -secretase-dependent processing.”
BindingDB (2021) · UC San Diego · doi:10.7270/q2m048x4
Metadata
- Authors
- Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C.
- Affiliations
- Technical University of Munich (DE)
- Adolf-Butenandt-Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie (DE)
- Venue
- The EMBO Reports
- Published
- 2002-07-01
- Volume
- 3
- Issue
- 7
- Pages
- 688-694
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2082694975
- Cited by
- 497
- References
- 56
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 7 · 2022: 13 · 2021: 15 · 2020: 14 · 2019: 27 · 2018: 13 · 2017: 17 · 2016: 25 · 2015: 16 · 2014: 19 · 2013: 28 · 2012: 34
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- gamma-secretase inhibitors, Notch signaling, presenilin, amyloid-beta, Alzheimer's disease, neurogenesis, zebrafish embryos, embryonic development, off-target effects, cell fate determination, adverse drug reactions
- MeSH terms
- Alzheimer Disease, Animals, Cell Line, Enzyme Inhibitors, gamma-Aminobutyric Acid, Humans, Membrane Proteins, Microinjections, Endopeptidases, Phenotype, RNA, Messenger, Triglycerides, Zebrafish, Signal Transduction, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, In Situ Hybridization, Body Patterning, Receptors, Notch, Presenilin-1, Amyloid Precursor Protein Secretases
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