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Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer
Open accessAbstract
Maf family transcription factors are important regulators in various differentiation systems. Putative Maf recognition elements (MAREs) are found in the 3' enhancer region of the immunoglobulin heavy chain (IgH) gene. These elements are bound in B-cell extracts by a heterodimeric protein complex containing both Bach2 and a small Maf protein. Analysis of normal hematopoietic cells revealed that Bach2 is specifically expressed in B cells. Bach2 is abundantly expressed in the early stages of B-cell differentiation and turned off in terminally differentiated cells. Bach2 acts together with MafK as a negative effector of the IgH 3' enhancer and binds to the co-repressor SMRT (silencing mediator of retinoid and thyroid receptor). Hence the Bach2-small-Maf heterodimer may represent the first example of a B-cell lineage, and of a developmental stage-restricted negative effector of the MARE in the IgH 3' enhancer region.
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“The latter protein is a small bZip transcription factor that, depending upon its heterodimeric partner, can either repress or activate gene expression (Hintze et al., 2007; Igarashi and Sun, 2006; Muto et al., 1998; Ochiai et al., 2006; Zhang et al., 2006).”
From Influence of Metabolism on Epigenetics and Disease (2013) · cites this paper as Muto et al., 1998
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Metadata
- Authors
- Muto, A., Hoshino, H., Madisen, L., Yanai, N., Obinata, M., Karasuyama, H., Hayashi, N., Nakauchi, H., Yamamoto, M., Groudine, M., & Igarashi, K.
- Affiliations
- University of Tsukuba (JP)
- Fred Hutch Cancer Center (US)
- Tohoku University (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- Corresponding author
- Igarashi, Kazuhiko
- Venue
- The EMBO Journal
- Published
- 1998-10-01
- Volume
- 17
- Issue
- 19
- Pages
- 5734-5743
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1170901
- OpenAlex
- W2106931266
- Cited by
- 190
- References
- 71
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 9 · 2015: 6 · 2014: 10 · 2013: 17 · 2012: 8
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Naito Foundation
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- BACH2, MafK, immunoglobulin heavy chain genes, 3' enhancer, B cell differentiation, transcriptional repression, heterodimeric transcription factors
- MeSH terms
- B-Lymphocytes, Cell Differentiation, Cell Line, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, Immunoglobulin, Hematopoietic Stem Cells, Immunoglobulin Heavy Chains, Nuclear Proteins, Proto-Oncogene Proteins, Transcription Factors, Leucine Zippers, Response Elements, Basic-Leucine Zipper Transcription Factors, MafK Transcription Factor, Proto-Oncogene Proteins c-maf
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