The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation
Open accessAbstract
Because of the heterogeneity of chromatin, the site of integration of human immunodeficiency virus (HIV) in the genome could have dramatic effects on its transcriptional activity. We have used an HIV-1-derived retroviral vector, in which the green fluorescent protein is under the control of the HIV promoter, to generate by infection 34 Jurkat clonal cell lines each containing a single integration of the HIV-1 vector. In the absence of Tat, a 75-fold difference in expression level between the highest and lowest expressing clones was observed. Basal promoter activity was low in 80% of the clones and moderate to high in the remaining 20% of clones. We found that differences in expression levels are due to the integration site and are not controlled by DNA methylation or histone acetylation. Tat activated transcription in each clone, and an inverse correlation was observed between basal transcriptional activity and inducibility by Tat. These observations demonstrate that the chromatin environment influences basal HIV gene expression and that the HIV Tat protein activates transcription independently of the chromatin environment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“However, it is now becoming clearer that certain retroviruses like HIV tend to target gene-rich, transcriptionally active, euchromatic regions within the host’s chromosome to integrate.”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Jordan et al. 2001
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, proviral integration in the transcriptionally active regions could potentially favor expression of the viral genes, whereas integration in the transcriptionally silent regions (heterochromatin) may not be in favor of viral expression and may even force the virus to stay transcriptionally silent (Jordan et al. 2001, Lewinski et al. 2006, Einkauf et al. 2022, Teixeira et al. 2024).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Jordan et al. 2001
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341
Dissecting the regulatory circuitry of a eukaryotic genome
Holstege, F. C. P., Jennings, E. G., Wyrick, J. J., Lee, T. I., Hengartner, C. J., Green, M. R., Golub, T. R., Lander, E. S., & Young, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81641-4 · Cited by 1,670
Ory, D., Neugeboren, B. I., & Mulligan, R. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11400 · Cited by 926
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product
Kao, S.-Y., Calman, A. F., Luciw, P. A., & Peterlin, B. M. (1987) · Nature · doi:10.1038/330489a0 · Cited by 908
HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap
Zennou, V., Petit, C., Guétard, D., Nerhbass, U., Montagnier, L., & Charneau, P. (2000) · Cell · doi:10.1016/s0092-8674(00)80828-4 · Cited by 864
Miller, M. D., Farnet, C. M., & Bushman, F. D. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5382-5390.1997 · Cited by 620
Lint, C. M. V., Emiliani, S., Ott, M., & Verdin, E. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00449.x · Cited by 579
Self-citationP-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitroPreprint
Mancebo, H. S. Y., Lee, G., Flygare, J. A., Tomassini, J. E., Luu, P., Zhu, Y., Peng, J., Blau, C., Hazuda, D. J., Price, D. H., et al. (1997) · Genes & Development · doi:10.1101/gad.11.20.2633 · Cited by 546
Binding and Stimulation of HIV-1 Integrase by a Human Homolog of Yeast Transcription Factor SNF5
Kalpana, G. V., Marmon, S., Wang, W., Crabtree, G. R., & Goff, S. P. (1994) · Science · doi:10.1126/science.7801128 · Cited by 530
Verdin, E. M., Paras, P., & Lint, C. M. V. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05994.x · Cited by 520
Self-citation
Cited by
Sorted by citations
HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
Schröder, A. R. W., Shinn, P., Chen, H., Berry, C., Ecker, J. R., & Bushman, F. (2002) · Cell · doi:10.1016/s0092-8674(02)00864-4 · Cited by 1,832
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
Jordan, A., Bisgrove, D., & Verdin, E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg188 · Cited by 914
Self-citationWeinberger, L. S., Burnett, J., Toettcher, J. E., Arkin, A. P., & Schaffer, D. V. (2005) · Cell · doi:10.1016/j.cell.2005.06.006 · Cited by 633
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
Ebina, H., Misawa, N., Kanemura, Y., & Koyanagi, Y. (2013) · Scientific Reports · doi:10.1038/srep02510 · Cited by 565
HIV LatencyPreprint
Siliciano, R. F., & Greene, W. C. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007096 · Cited by 552
Transcriptional burst frequency and burst size are equally modulated across the human genome
Dar, R. D., Razooky, B. S., Singh, A., Trimeloni, T. V., McCollum, J. M., Cox, C. D., Simpson, M. L., & Weinberger, L. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213530109 · Cited by 491
HIV-1 Integration Landscape during Latent and Active Infection
Cohn, L. B., da Silva, I. T., Oliveira, T. Y., Rosales, R., Parrish, E. H., Learn, G. H., Hahn, B. H., Czartoski, J., McElrath, M. J., Lehmann, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.020 · Cited by 460
Stevenson, M. (2003) · Nature Medicine · doi:10.1038/nm0703-853 · Cited by 455
Genome-wide analysis of retroviral DNA integration
Bushman, F. D., Lewinski, M. K., Ciuffi, A., Barr, S. D., Leipzig, J. N., Hannenhalli, S. S., & Hoffmann, C. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1263 · Cited by 437
Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation
Kauder, S. E., Bosque, A., Lindkvist, A., Planelles, V., & Verdin, E. M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000495 · Cited by 371
Self-citationMicroglial Cells: The Main HIV-1 Reservoir in the Brain
Wallet, C., Rovere, M. D., Assche, J. V., Daouad, F., Wit, S. D., Gautier, V., Mallon, P. W. G., Marcello, A., Lint, C. M. V., Rohr, O., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00362 · Cited by 378
Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
Tchasovnikarova, I. A., Timms, R. T., Matheson, N. J., Wals, K., Antrobus, R., Göttgens, B., Dougan, G., Dawson, M. A., & Lehner, P. J. (2015) · Science · doi:10.1126/science.aaa7227 · Cited by 375
Targeting the Latent Reservoir for HIV-1
Sengupta, S., & Siliciano, R. F. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.030 · Cited by 352
Yukl, S. A., Kaiser, P. D., Kim, P., Telwatte, S., Joshi, S. K., Vu, M., Lampiris, H. W., & Wong, J. K. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aap9927 · Cited by 338
Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid
Archin, N. M., Espeseth, A. S., Parker, D., Cheema, M., Hazuda, D. J., & Margolis, D. M. (2009) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2008.0191 · Cited by 336
CpG Methylation Controls Reactivation of HIV from Latency
Blažková, J., Trejbalová, K., Gondois‐Rey, F., Halfon, P., Patrick, P., Guiguen, A., Verdin, E. M., Olive, D., Lint, C. M. V., Hejnar, J., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000554 · Cited by 349
Self-citationHan, Y., Lassen, K. G., Monie, D., Sedaghat, A. R., Shimoji, S., Liu, X., Pierson, T. C., Margolick, J. B., Siliciano, R. F., & Siliciano, J. D. (2004) · Journal of Virology · doi:10.1128/jvi.78.12.6122-6133.2004 · Cited by 348
Craigie, R., & Bushman, F. D. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006890 · Cited by 327
Prostratin Antagonizes HIV Latency by Activating NF-κB
Williams, S. A., Chen, L., Kwon, H., Fenard, D., Bisgrove, D. A., Verdin, E. M., & Greene, W. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402124200 · Cited by 323
Self-citationLlano, M., Vanegas, M., Fregoso, O., Saenz, D., Chung, S., Peretz, M., & Poeschla, E. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.17.9524-9537.2004 · Cited by 305
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
Greene, W. C., & Peterlin, B. M. (2002) · Nature Medicine · doi:10.1038/nm0702-673 · Cited by 293
Genome-Wide Analysis of Chromosomal Features Repressing Human Immunodeficiency Virus Transcription
Lewinski, M. K., Bisgrove, D. A., Shinn, P., Chen, H., Hoffmann, C., Hannenhalli, S. S., Verdin, E. M., Berry, C. C., Ecker, J. R., & Bushman, F. D. (2005) · Journal of Virology · doi:10.1128/jvi.79.11.6610-6619.2005 · Cited by 286
Self-citationSingh, A., Razooky, B. S., Cox, C. D., Simpson, M. L., & Weinberger, L. S. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.03.001 · Cited by 241
Emiliani, S., Mousnier, A., Busschots, K., Maroun, M., Maele, B. V., Tempé, D., Vandekerckhove, L., Moisant, F., Benslama, L., Witvrouw, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501378200 · Cited by 243
Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting
Marshall, H. M., Ronen, K., Berry, C., Llano, M., Sutherland, H., Saenz, D., Bickmore, W., Poeschla, E., & Bushman, F. D. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001340 · Cited by 241
Reuse, S., Calao, M., Kabeya, K., Guiguen, A., Gatot, J., Quivy, V., Vanhulle, C., Lamine, A., Vaira, D., Demonté, D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006093 · Cited by 242
The multifactorial nature of HIV-1 latency
Lassen, K. G., Han, Y., Zhou, Y., Siliciano, J. D., & Siliciano, R. F. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.006 · Cited by 240
Lesbats, P., Engelman, A., & Cherepanov, P. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00125 · Cited by 250
A Hardwired HIV Latency Program
Razooky, B. S., Pai, A., Aull, K. H., Rouzine, I. M., & Weinberger, L. S. (2015) · Cell · doi:10.1016/j.cell.2015.02.009 · Cited by 229
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
Lakshmanan, G., Burstein, E., Guha-Niyogi, A., Louder, M. K., Mascola, J. R., Klomp, L. W. J., Wijmenga, C., Duckett, C. S., & Nabel, G. J. (2003) · Nature · doi:10.1038/nature02171 · Cited by 226
Reactivation of latent HIV by histone deacetylase inhibitors
Shirakawa, K., Chávez, L., Hakre, S., Calvanese, V., & Verdin, E. M. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.02.005 · Cited by 214
Self-citationHan, Y., Lin, Y. B., An, W., Xu, J., Yang, H., O’Connell, K. A., Dordai, D. I., Boeke, J. D., Siliciano, J. D., & Siliciano, R. F. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.06.008 · Cited by 228
Understanding HIV Latency: The Road to an HIV Cure
Dahabieh, M. S., Battivelli, E., & Verdin, E. M. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-092112-152941 · Cited by 215
Self-citationDequiedt, F., Kasler, H. G., Fischle, W., Kiermer, V., Weinstein, M., HERNDIER, B. G., & Verdin, E. M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00109-2 · Cited by 218
Self-citationExperimental approaches to the study of HIV-1 latency
Han, Y., Wind‐Rotolo, M., Yang, H., Siliciano, J. D., & Siliciano, R. F. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1580 · Cited by 212
Transient-mediated fate determination in a transcriptional circuit of HIV
Weinberger, L. S., Dar, R. D., & Simpson, M. L. (2007) · Nature Genetics · doi:10.1038/ng.116 · Cited by 191
Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage
Douce, V. L., Herbein, G., Rohr, O., & Schwartz, C. (2010) · Retrovirology · doi:10.1186/1742-4690-7-32 · Cited by 191
Molecular Characterization, Reactivation, and Depletion of Latent HIV
Brooks, D. G., Hamer, D. H., Arlen, P. A., Gao, L., Bristol, G., Ramirez, C. M., Berger, E. A., & Zack, J. A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00236-x · Cited by 196
The transcriptional cycle of HIV-1 in real-time and live cells
Boireau, S., Maiuri, P., Basyuk, E., de la Mata, M., Knezevich, A., Pradet-Balade, B., Bäcker, V., Kornblihtt, A., Marcello, A., & Bertrand, E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706018 · Cited by 191
Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency
Rafati, H., Parra, M., Hakre, S., Moshkin, Y. M., Verdin, E. M., & Mahmoudi, T. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001206 · Cited by 188
Self-citationHermankova, M., Siliciano, J. D., Zhou, Y., Monie, D., Chadwick, K. R., Margolick, J. B., Quinn, T. C., & Siliciano, R. F. (2003) · Journal of Virology · doi:10.1128/jvi.77.13.7383-7392.2003 · Cited by 189
Basics of the virology of HIV-1 and its replication
Sierra, S., Kupfer, B., & Kaiser, R. (2005) · Journal of Clinical Virology · doi:10.1016/j.jcv.2005.09.004 · Cited by 206
Battivelli, E., Dahabieh, M. S., Abdel‐Mohsen, M., Svensson, J. P., da Silva, I. T., Cohn, L. B., Gramatica, A., Deeks, S. G., Greene, W. C., Pillai, S. K., et al. (2018) · eLife · doi:10.7554/elife.34655 · Cited by 183
Self-citationPerera, S. A., Li, D., Shimamura, T., Raso, M. G., Ji, H., Chen, L., Borgman, C. L., Zaghlul, S., Brandstetter, K. A., Kubo, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808930106 · Cited by 189
Swiggard, W. J., Baytop, C., Yu, J. J., Dai, J., Li, C., Schretzenmair, R., Theodosopoulos, T., & O'Doherty, U. (2005) · Journal of Virology · doi:10.1128/jvi.79.22.14179-14188.2005 · Cited by 182
The SWI/SNF Chromatin-remodeling Complex Is a Cofactor for Tat Transactivation of the HIV Promoter
Mahmoudi, T., Parra, M., Vries, R. G. J., Kauder, S. E., Verrijzer, C. P., Ott, M., & Verdin, E. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603336200 · Cited by 182
Self-citationTréand, C., du Chéné, I., Brès, V., Kiernan, R. E., Bénarous, R., Benkirane, M., & Emiliani, S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601074 · Cited by 178
Hide, shield and strike back: how HIV-infected cells avoid immune eradication
Peterlin, B. M., & Trono, D. (2003) · Nature reviews. Immunology · doi:10.1038/nri998 · Cited by 176
Kwon, H., Brent, M. M., Getachew, R., Jayakumar, P., Chen, L., Schnölzer, M., McBurney, M. W., Marmorstein, R., Greene, W. C., & Ott, M. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.002 · Cited by 181
Hultquist, J. F., Schumann, K., Woo, J. M., Manganaro, L., McGregor, M. J., Doudna, J., Simon, V., Krogan, N. J., & Marson, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.080 · Cited by 170
Position effects influence HIV latency reversal
Chen, H., Martínez, J. P., Zorita, E. V., Meyerhans, A., & Filion, G. J. P. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3328 · Cited by 164
Latency in Human Immunodeficiency Virus Type 1 Infection: No Easy Answers
Persaud, D., Zhou, Y., Siliciano, J. D., & Siliciano, R. F. (2003) · Journal of Virology · doi:10.1128/jvi.77.3.1659-1665.2003 · Cited by 168
Lassen, K. G., Bailey, J. R., & Siliciano, R. F. (2004) · Journal of Virology · doi:10.1128/jvi.78.17.9105-9114.2004 · Cited by 161
Vigna, E., Cavalieri, S., Ailles, L., Geuna, M., Loew, R., Bujard, H., & Naldini, L. (2002) · Molecular Therapy · doi:10.1006/mthe.2002.0542 · Cited by 147
HIV integration site distributions in resting and activated CD4 + T cells infected in culture
Brady, T., Agosto, L. M., Malani, N., Berry, C. C., O’Doherty, U., & Bushman, F. D. (2009) · AIDS · doi:10.1097/qad.0b013e32832caf28 · Cited by 154
Ramezani, A., Hawley, T., & Hawley, R. (2003) · Blood · doi:10.1182/blood-2002-09-2991 · Cited by 143
Regulation of HIV-1 gene transcription: from lymphocytes to microglial cells
Rohr, O., Marban, C., Aunis, D., & Schaeffer, E. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403180 · Cited by 142
McNamara, R. P., Reeder, J. E., McMillan, E. A., Bacon, C. W., McCann, J. L., & D’Orso, I. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.004 · Cited by 142
Retroviral DNA Integration—Mechanism and Consequences
Lewinski, M. K., & Bushman, F. D. (2005) · Advances in genetics · doi:10.1016/s0065-2660(05)55005-3 · Cited by 140
Stochastic gene expression as a molecular switch for viral latency
Singh, A., & Weinberger, L. S. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.06.016 · Cited by 132
Ikeda, T., Shibata, J., Yoshimura, K., Koito, A., & Matsushita, S. (2007) · The Journal of Infectious Diseases · doi:10.1086/510915 · Cited by 130
Latency: the hidden HIV-1 challenge
Marcello, A. (2006) · Retrovirology · doi:10.1186/1742-4690-3-7 · Cited by 131
Orthogonal control of expression mean and variance by epigenetic features at different genomic loci
Dey, S. S., Foley, J. E., Limsirichai, P., Schaffer, D. V., & Arkin, A. P. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145704 · Cited by 119
HIV-1 gene expression: lessons from provirus and non-integrated DNA
Wu, Y. (2004) · Retrovirology · doi:10.1186/1742-4690-1-13 · Cited by 124
Regulation of HIV-1 latency by T-cell activation
Williams, S. A., & Greene, W. C. (2007) · Cytokine · doi:10.1016/j.cyto.2007.05.017 · Cited by 124
Acetylation of Tat Defines a CyclinT1-Independent Step in HIV Transactivation
Kaehlcke, K., Dorr, A., Hetzer‐Egger, C., Kiermer, V., Henklein, P., Schnoelzer, M., Loret, E. P., Cole, P. A., Verdin, E. M., & Ott, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00245-4 · Cited by 121
Self-citationRetroviral DNA integration: HIV and the role of LEDGF/p75.
Ciuffi, A., & Bushman, F. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.05.006 · Cited by 134
Hide-and-Seek: The Challenge of Viral Persistence in HIV-1 Infection
Geeraert, L., Kraus, G., & Pomerantz, R. J. (2007) · Annual Review of Medicine · doi:10.1146/annurev.med.59.062806.123001 · Cited by 120
Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy
Lian, X., Seiger, K. W., Parsons, E. M., Gao, C., Sun, W., Gladkov, G. T., Roseto, I. C., Einkauf, K. B., Osborn, M. R., Chevalier, J. M., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2022.12.002 · Cited by 124
Quivy, V., Adam, E., Collette, Y., Demonté, D., Chariot, A., Vanhulle, C., Berkhout, B., Castellano, R., de Launoit, Y., Burny, A., et al. (2002) · Journal of Virology · doi:10.1128/jvi.76.21.11091-11103.2002 · Cited by 116
Shen, A., Zink, M. C., Mankowski, J. L., Chadwick, K. R., Margolick, J. B., Carruth, L. M., Li, M., Clements, J. E., & Siliciano, R. F. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4938-4949.2003 · Cited by 119
Vranckx, L. S., Demeulemeester, J., Saleh, S., Boll, A., Vansant, G., Schrijvers, R., Weydert, C., Battivelli, E., Verdin, E., Cereseto, A., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.04.039 · Cited by 113
Self-citationInfluence of Host Gene Transcription Level and Orientation on HIV-1 Latency in a Primary-Cell Model
Shan, L., Yang, H., Rabi, S. A., Bravo, H. C., Shroff, N. S., Irizarry, R. A., Zhang, H., Margolick, J. B., Siliciano, J. D., & Siliciano, R. F. (2011) · Journal of Virology · doi:10.1128/jvi.02536-10 · Cited by 123
HIV latency and integration site placement in five cell-based models
Sherrill-Mix, S. A., Lewinski, M. K., Famiglietti, M., Bosque, A., Malani, N., Ocwieja, K. E., Berry, C. C., Looney, D. J., Shan, L., Agosto, L. M., et al. (2013) · Retrovirology · doi:10.1186/1742-4690-10-90 · Cited by 117
Kolossov, E., Lu, Z., Drobinskaya, I., Gassanov, N., Duan, Y., Sauer, H., Manzke, O., Bloch, W., Bohlen, H., Hescheler, J., et al. (2005) · The FASEB Journal · doi:10.1096/fj.03-1451fje · Cited by 111
Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription
Agbottah, E. T., Deng, L., Dannenberg, L. O., Pumfery, A. M., & Kashanchi, F. (2006) · Retrovirology · doi:10.1186/1742-4690-3-48 · Cited by 110
Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency
Duverger, A. E., Jones, J., May, J. E., Bibollet‐Ruche, F., Wagner, F. A., Cron, R. Q., & Kutsch, O. (2009) · Journal of Virology · doi:10.1128/jvi.02058-08 · Cited by 114
Telwatte, S., Lee, S. A., Somsouk, M., Hatano, H., Baker, C. A. R., Kaiser, P. D., Kim, P., Chen, T., Milush, J. M., Hunt, P. W., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007357 · Cited by 110
Establishment of latent HIV-1 reservoirs: what do we really know?
Vanhamel, J., Bruggemans, A., & Debyser, Z. (2019) · Journal of Virus Eradication · doi:10.1016/s2055-6640(20)30275-2 · Cited by 125
Control of Stochastic Gene Expression by Host Factors at the HIV Promoter
Burnett, J., Miller‐Jensen, K., Shah, P. S., Arkin, A. P., & Schaffer, D. V. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000260 · Cited by 103
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
Brooks, D. G., Arlen, P. A., Gao, L., Ramirez, C. M., & Zack, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233345100 · Cited by 106
Combinatorial Latency Reactivation for HIV-1 Subtypes and Variants
Burnett, J., Lim, K., Calafi, A., Rossi, J. J., Schaffer, D. V., & Arkin, A. P. (2010) · Journal of Virology · doi:10.1128/jvi.00161-10 · Cited by 106
Marban-Doran, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki529 · Cited by 103
RetractedSMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency
Boehm, D., Jeng, M. Y., Camus, G., Gramatica, A., Schwarzer, R., Johnson, J. R., Hull, P. A., Montaño, M., Sakane, N., Pagans, S., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.04.011 · Cited by 100
HIV Promoter Integration Site Primarily Modulates Transcriptional Burst Size Rather Than Frequency
Skupsky, R., Burnett, J., Foley, J. E., Schaffer, D. V., & Arkin, A. P. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000952 · Cited by 99
Ensoli, B., Bellino, S., Tripiciano, A., Longo, O., Francavilla, V., Marcotullio, S., Cafaro, A., Picconi, O., Paniccia, G., Scoglio, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013540 · Cited by 97
Kwon, K. J., Timmons, A. E., Sengupta, S., Simonetti, F. R., Zhang, H., Hoh, R., Deeks, S. G., Siliciano, J. D., & Siliciano, R. F. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax6795 · Cited by 98
Lian, X., Gao, C., Sun, X., Jiang, C., Einkauf, K. B., Seiger, K. W., Chevalier, J. M., Yuki, Y., Martin, M. P., Hoh, R., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abl4097 · Cited by 100
Lin, X., Irwin, D., Kanazawa, S., Huang, L., Romeo, J. M., Yen, T. S. B., & Peterlin, B. M. (2003) · Journal of Virology · doi:10.1128/jvi.77.15.8227-8236.2003 · Cited by 94
Berro, R., Kehn‐Hall, K., de la Fuente, C., Pumfery, A. M., Adair, R., Wade, J. D., Colberg‐Poley, A. M., Hiscott, J. B., & Kashanchi, F. (2006) · Journal of Virology · doi:10.1128/jvi.80.7.3189-3204.2006 · Cited by 92
Greenwood, E. J. D., Williamson, J. C., Sienkiewicz, A., Naamati, A., Matheson, N. J., & Lehner, P. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.025 · Cited by 95
Mechanisms of HIV Latency: an Emerging Picture of Complexity
Margolis, D. M. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-009-0033-9 · Cited by 89
Tan, W., Dong, Z., Wilkinson, T. A., Barbas, C., & Chow, S. A. (2006) · Journal of Virology · doi:10.1128/jvi.80.4.1939-1948.2006 · Cited by 89
An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer
Weinberger, L. S., & Shenk, T. E. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0050009 · Cited by 89
Chromatin Reassembly Factors Are Involved in Transcriptional Interference Promoting HIV Latency
Gallastegui, E., Millán-Zambrano, G., Terme, J.-M., Chávez, S., & Jordan, A. (2011) · Journal of Virology · doi:10.1128/jvi.01920-10 · Cited by 87
Self-citationCuring HIV: Pharmacologic Approaches to Target HIV-1 Latency
Choudhary, S. K., & Margolis, D. M. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100237 · Cited by 83
Althaus, C. L., & de Boer, R. J. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.4 · Cited by 85
MicroRNA-155 Reinforces HIV Latency
Ruelas, D. S., Chan, J. K., Oh, E., Heidersbach, A. J., Hebbeler, A. M., Chávez, L., Verdin, E. M., Rapé, M., & Greene, W. C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.641837 · Cited by 87
Self-citationHIV-1 Latency: An Update of Molecular Mechanisms and Therapeutic Strategies
Battistini, A., & Sgarbanti, M. (2014) · Viruses · doi:10.3390/v6041715 · Cited by 86
Common Threads in Persistent Viral Infections
Kane, M., & Golovkina, T. (2009) · Journal of Virology · doi:10.1128/jvi.01905-09 · Cited by 88
Metadata
- Authors
- Jordan, A., Defechereux, P., & Verdin, E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Verdin, Eric
- Venue
- The EMBO Journal
- Published
- 2001-04-02
- Volume
- 20
- Issue
- 7
- Pages
- 1726-1738
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC145503
- OpenAlex
- W1964660012
- Cited by
- 467
- References
- 48
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 19 · 2023: 18 · 2022: 15 · 2021: 15 · 2020: 21 · 2019: 21 · 2018: 20 · 2017: 26 · 2016: 25 · 2015: 27 · 2014: 14 · 2013: 15 · 2012: 14
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Belgian American Educational Foundation
- National Institutes of Health
- National Institute of General Medical Sciences (GM51671-05A2, R01GM051671)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Tat transactivation, basal transcription, chromatin environment, HIV-1 promoter, retroviral vectors, Jurkat cells, DNA methylation, histone acetylation, HIV gene expression
- MeSH terms
- Binding Sites, Cell Line, Transformed, Genetic Vectors, HeLa Cells, Humans, Hydroxamic Acids, Promoter Regions, Genetic, Tetradecanoylphorbol Acetate, Transcription, Genetic, HIV-1, Transcriptional Activation, Gene Products, tat, Genome, Human, Gene Expression Regulation, Viral, HIV Long Terminal Repeat, Virus Integration, Cyclin-Dependent Kinases, Jurkat Cells, DNA Methylation, Cyclin-Dependent Kinase 9, tat Gene Products, Human Immunodeficiency Virus, Histone Deacetylase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
