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Transient EZH2 Suppression by Tazemetostat during In Vitro Expansion Maintains T-Cell Stemness and Improves Adoptive T-Cell Therapy

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EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells

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EZH2 overexpression dampens tumor-suppressive signals via an EGR1 silencer to drive breast tumorigenesis

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BCL2L10 is frequently silenced by promoter hypermethylation in gastric cancer

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Pharmacologic down-regulation of EZH2 suppresses bladder cancerin vitroandin vivo

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Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf‐1, p27, and PCNA in Barrett's esophagus

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EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization

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Lineage plasticity and histological transformation: tumor histology as a spectrum

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Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activation

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Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands

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Autoregulatory feedback loop of EZH2/miR-200c/E2F3 as a driving force for prostate cancer development

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Replication stress, a source of epigenetic aberrations in cancer?

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Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer

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Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma

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Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer

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Microchidia protein 2, MORC2, downregulates the cytoskeleton adapter protein, ArgBP2, via histone methylation in gastric cancer cells

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Zodiac: A Comprehensive Depiction of Genetic Interactions in Cancer by Integrating TCGA Data

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Integrating genetics and epigenetics in myelodysplastic syndromes: advances in pathogenesis and disease evolution

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EZH2 Silencing with RNA Interference Induces G2/M Arrest in Human Lung Cancer CellsIn Vitro

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Epigenetic Regulation of the Epithelial to Mesenchymal Transition in Lung Cancer

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The Complex Role of EZH2 in the Tumor Microenvironment: Opportunities and Challenges for Immunotherapy Combinations

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Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer

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Deregulation of EZH2 expression in human spermatogenic disorders and testicular germ cell tumors

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Enhancer of zeste homolog 2 is widely expressed in T-cell neoplasms, is associated with high proliferation rate and correlates with MYC and pSTAT3 expression in a subset of cases

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Double sword role of EZH2 in leukemia

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Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing ofCDX1andEPHBtumor suppressor genes in colorectal cancer

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Functional and therapeutic significance of EZH2 in urological cancers

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EZH2 Overexpression as a Useful Prognostic Marker for Aggressive Behaviour in Thyroid Cancer

Masudo, K., Suganuma, N., NAKAYAMA, H., Oshima, T., Rino, Y., Iwasaki, H., Matsuzu, K., Sugino, K., Ito, K., Kondo, T., et al. (2018) · In Vivo · doi:10.21873/invivo.11200 · Cited by 28

EZH2 inhibition reduces cartilage loss and functional impairment related to osteoarthritis

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Wilms Tumor Suppressor, WT1, Suppresses Epigenetic Silencing of the β-Catenin Gene

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The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer

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Temporal expression changes during differentiation of neural stem cells derived from mouse embryonic stem cell

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SUMOylation of E2F1 Regulates Expression of EZH2

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Chemical biology and pharmacology of histone lysine methylation inhibitors

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SETD1A-SOX2 axis is involved in tamoxifen resistance in estrogen receptor α-positive breast cancer cells

Jin, M. L., Liu, Y., & Jeong, K. W. (2022) · Theranostics · doi:10.7150/thno.72599 · Cited by 27

Targeting EZH2 in SMARCB1-deficient sarcomas: Advances and opportunities to potentiate the efficacy of EZH2 inhibitors

Lanzi, C., Arrighetti, N., Pasquali, S., & Cassinelli, G. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115727 · Cited by 27

Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context

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Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer

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Targeting EZH2 for glioma therapy with a novel nanoparticle–siRNA complex

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Chromatin Structure Regulation in Transforming Growth Factor-β-Directed Epithelial-Mesenchymal Transition

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Merkel cell carcinoma: updates in tumor biology, emerging therapies, and preclinical models

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Pocket Proteins Suppress Head and Neck Cancer

Shin, M.-K., Pitot, H. C., & Lambert, P. F. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2833 · Cited by 26

Single-Cell RNA Sequencing Reveals the Role of Phosphorylation-Related Genes in Hepatocellular Carcinoma Stem Cells

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Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behavior

Li, K., Sun, L., Wang, Y., Cen, Y., Zhao, J., Liao, Q., Wu, W., Sun, J., & Zhou, M. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01115-9 · Cited by 27

Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention

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Sorafenib suppresses growth and survival of hepatoma cells by accelerating degradation of enhancer of zeste homolog 2

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Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

Koppens, M. A. J., Bounova, G., Cornelissen‐Steijger, P., de Vries, N., Sansom, O. J., Wessels, L. F. A., & van Lohuizen, M. (2016) · Oncotarget · doi:10.18632/oncotarget.12002 · Cited by 27

Mutations and deletions of PRC2 in prostate cancer

Jain, P., & Croce, L. D. (2016) · BioEssays · doi:10.1002/bies.201500162 · Cited by 26

The Research Progress of EZH2 Genes in Tumors

Hong-me, W. (2014) · Medical Recapitulate

Importance of Ezh2 polycomb protein in tumorigenesis process interfering with the pathway of growth suppressive key elements

Tonini, T., D’Andrilli, G., Fucito, A., Gaspa, L., & Bagella, L. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21241 · Cited by 75

The role of the polycomb group protein EZH2 in the molecular pathogenesis of prostate cancer

Bryant, R. J. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)

Roles of EZH2 Histone Methyltransferase in Tumorigenesis

We, D. (2011) · Journal of International Obstetrics and Gynecology

EZH2: Not EZHY (Easy) to Deal

Deb, G., Singh, A. K., & Gupta, S. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0546 · Cited by 110