Helin, Kristian

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.

Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal

Epigenetics and DNA MethylationCancer-related gene regulation

Cited by 1,196

Role of TET enzymes in DNA methylation, development, and cancer

Rasmussen, K. D., & Helin, K. (2016) · Genes & Development

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 1,040

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 1,021

Transcriptional regulation by Polycomb group proteins

Di Croce, L., & Helin, K. (2013) · Nature Structural & Molecular Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 864

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes & Development

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 850

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

Bender, S., Tang, Y., Lindroth, A. M., Hovestadt, V., Jones, D. T. W., Kool, M., Zapatka, M., Northcott, P. A., Sturm, D., Wang, W., et al. (2013) · Cancer Cell

Glioma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 818

Molecular mechanisms directing PRC2 recruitment and H3K27 methylation

Laugesen, A., Højfeldt, J. W., & Helin, K. (2019) · Molecular Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 602

Apaf-1 is a transcriptional target for E2F and p53

Moroni, M. C., Hickman, E. S., Denchi, E. L., Caprara, G., Colli, E., Cecconi, F., Müller, H., & Helin, K. (2001) · Nature Cell Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 593

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

Mohammad, F., Weissmann, S., Leblanc, B., Pandey, D. P., Højfeldt, J. W., Comet, I., Zheng, C., Johansen, J. V., Rapin, N., Porse, B. T., et al. (2017) · Nature Medicine

Glioma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 535

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A–ARF locus in response to oncogene- and stress-induced senescence

Agger, K., Cloos, P. A. C., Rudkjær, L., Williams, K., Andersen, G., Christensen, J., & Helin, K. (2009) · Genes & Development

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 427

H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

Wang, H., Fan, Z., Shliaha, P. V., Miele, M., Hendrickson, R. C., Jiang, X., & Helin, K. (2023) · Nature

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 422

Chromatin repressive complexes in stem cells, development, and cancer

Laugesen, A., & Helin, K. (2014) · Cell stem cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 352

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., & Marine, J.-C. (2002) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 313

Amplification of Mdmx (or Mdm4 ) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

Danovi, D., Meulmeester, E., Pasini, D., Migliorini, D., Capra, M., Frenk, R., de Graaf, P., Francoz, S., Gasparini, P., Gobbi, A., et al. (2004) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 310

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

Rasmussen, K. D., Jia, G., Johansen, J. V., Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, B. T., Bernard, O. A., Christensen, J., & Helin, K. (2015) · Genes & Development

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 270

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation

Klauke, K., Radulović, V., Broekhuis, M., Weersing, E., Zwart, E., Olthof, S., Ritsema, M., Bruggeman, S., Wu, X., Helin, K., et al. (2013) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 237

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

de la Rica, L., Rodríguez-Ubreva, J., García, M., Islam, A. B., Urquiza, J. M., Hernando, H., Christensen, J., Helin, K., Gómez-Vaquero, C., & Ballestar, E. (2013) · Genome Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 211

Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary Gland

Denchi, E. L., Attwooll, C., Pasini, D., & Helin, K. (2005) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 195

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

Fortin, A., Cregan, S. P., MacLaurin, J. G., Kushwaha, N., Hickman, E. S., Thompson, C. S., Hakim, A., Albert, P. R., Cecconi, F., Helin, K., et al. (2001) · The Journal of Cell Biology

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 194

Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A‐ARF locus

Dietrich, N., Bracken, A. P., Trinh, E., Schjerling, C. K., Koseki, H., Rappsilber, J., Helin, K., & Hansen, K. H. (2007) · The EMBO Journal

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 187

Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and Repressors: diffTF

Berest, I., Arnold, C., Reyes-Palomares, A., Palla, G., Rasmussen, K. D., Giles, H., Bruch, P.-M., Huber, W., Dietrich, S., Helin, K., et al. (2019) · Cell Reports

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 119

TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis

Tulstrup, M., Soerensen, M., Hansen, J. W., Gillberg, L., Needhamsen, M., Kaastrup, K., Helin, K., Christensen, K., Weischenfeldt, J., & Grønbæk, K. (2021) · Nature Communications

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 108

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

Rasmussen, K. D., Berest, I., Keβler, S., Nishimura, K., Simón-Carrasco, L., Vassiliou, G. S., Pedersen, M. T., Christensen, J., Zaugg, J. B., & Helin, K. (2019) · Genome Research

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 95

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Piunti, A., Rossi, A., Cerutti, A., Albert, M., Jammula, S., Scelfo, A., Cedrone, L., Fragola, G., Olsson, L., Koseki, H., et al. (2014) · Nature Communications

Epigenetics and DNA MethylationCancer-related Molecular Pathways

Cited by 93