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Calcium transients in mammalian ventricular muscle
Abstract
The calcium-sensitive photoprotein aequorin was microinjected into cells of rat and cat ventricular muscle. During subsequent stimulation of the muscle light emission could be detected and this signal is a function of the intracellular [Ca ++ ]. The time course and amplitude of the intracellular [Ca ++ ] transient occurring during contraction is described. The effects on tension and light emission of changing external [Ca ++ ] and stimulus frequency and of adding adrenaline and caffeine to the bathing solution are described. These results show that changes in external calcium and stimulus frequency alter tension by means of changes in the intracellular [Ca ++ ] whereas adrenaline in addition alters the sensitivity of the contractile system to intracellular [Ca ++ ]. The results also suggest that although a fall in intracellular [Ca ++ ] always precedes relaxation, the time course of the fall of [Ca ++ ] is not generally a rate limiting step in the lime course of relaxation.
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Cited by
Calcium and Excitation-Contraction Coupling in the Heart
Eisner, D. A., Caldwell, J. L., Kistamás, K., & Trafford, A. W. (2017) · Circulation Research · doi:10.1161/circresaha.117.310230 · Cited by 866
Magnesium: Nature's physiologic calcium blocker
Iseri, L. T., & French, J. H. (1984) · American Heart Journal · doi:10.1016/0002-8703(84)90572-6 · Cited by 831
A model of cardiac electrical activity incorporating ionic pumps and concentration changes
Di Francesco, D., & Noble, D. (1985) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1985.0001 · Cited by 827
Measurement of Ca2+ concentrations in living cells
Blinks, J. R., Wier, W. G., Hess, P., & Prendergast, F. G. (1982) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(82)90011-6 · Cited by 654
The cellular basis of the length-tension relation in cardiac muscle
ALLEN, D., & KENTISH, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80097-3 · Cited by 589
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Metadata
- Authors
- Allen, D. G., & Kurihara, S.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-01-02
- Volume
- 1
- Issue
- suppl 1
- Pages
- 5-15
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2094276784
- Cited by
- 233
- References
- 0
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Allen, D. G., & Kurihara, S. (1980). Calcium transients in mammalian ventricular muscle. European Heart Journal. https://doi.org/10.1093/eurheartj/1.suppl_1.5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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