The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Calcium and Excitation-Contraction Coupling in the Heart
Open accessAbstract
Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca 2+ ] i ). Normal function requires that [Ca 2+ ] i be sufficiently high in systole and low in diastole. Much of the Ca needed for contraction comes from the sarcoplasmic reticulum and is released by the process of calcium-induced calcium release. The factors that regulate and fine-tune the initiation and termination of release are reviewed. The precise control of intracellular Ca cycling depends on the relationships between the various channels and pumps that are involved. We consider 2 aspects: (1) structural coupling: the transporters are organized within the dyad, linking the transverse tubule and sarcoplasmic reticulum and ensuring close proximity of Ca entry to sites of release. (2) Functional coupling: where the fluxes across all membranes must be balanced such that, in the steady state, Ca influx equals Ca efflux on every beat. The remainder of the review considers specific aspects of Ca signaling, including the role of Ca buffers, mitochondria, Ca leak, and regulation of diastolic [Ca 2+ ] i .
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Cites
Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction
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Store-Operated Calcium Channels
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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
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Excitation-Contraction Coupling and Cardiac Contractile Force
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Excitation-Contraction Coupling and Cardiac Contractile Force
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Cited by
Giacomelli, E., Meraviglia, V., Campostrini, G., Cochrane, A., Cao, X., van Helden, R. W. J., Krotenberg Garcia, A., Mircea, M., Kostidis, S., Davis, R. P., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.05.004 · Cited by 622
The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms
Salvatore, T., Pafundi, P. C., Galiero, R., Albanese, G., Di Martino, A., Caturano, A., Vetrano, E., Rinaldi, L., & Sasso, F. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.695792 · Cited by 165
Xiao, Y., Hu, L., Duan, J., Che, H., Wang, W., Yuan, Y., Xu, J., Chen, D., & Zhao, S. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124022 · Cited by 49
Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart
Arrieta, A., Blackwood, E. A., Stauffer, W. T., & Glembotski, C. C. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00193 · Cited by 27
Gao, S., Puthenvedu, D., Lombardi, R., & Chen, S. N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176320 · Cited by 28
Metadata
- Authors
- Eisner, D. A., Caldwell, J. L., Kistamás, K., & Trafford, A. W.
- Venue
- Circulation Research
- Published
- 2017-07-07
- Volume
- 121
- Issue
- 2
- Pages
- 181-195
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2728447508
- Cited by
- 866
- References
- 121
- FWCI
- 38.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Eisner, D. A., Caldwell, J. L., Kistamás, K., & Trafford, A. W. (2017). Calcium and Excitation-Contraction Coupling in the Heart. Circulation Research. https://doi.org/10.1161/circresaha.117.310230
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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