Experimental giant cell myocarditis induced by cardiac myosin immunization
Abstract
To identify a cardiac protein that could cause a serious autoimmune myocarditis, membranous proteins and myosin as antigens were investigated. In mice immunized with membranous proteins, the lesions induced were limited on the histological level. On the other hand, in Lewis rats immunized with cardiac myosin, serious myocarditis was induced. Every rat showed evidence of heart failure which was fatal in a few. Histology disclosed extensive cell infiltrates and myocardial necrosis. Among those lesions, giant cells were present. This myocarditis could be also transferred adoptively by lectin-activated spleen cells, T-lymphocytes, but not by IgG fraction. Thus, cardiac myosin can induce autoimmune giant cell myocarditis in Lewis rats.
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Transfer of antibodies from cardiac myosin-immunized rats did not elicit myocarditis in recipient rats.
“the transfer of antibodies from these immunized rats did not elicit myocarditis in recipient rats”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [57]
Autoreactive T cells targeting heart antigens may play a crucial role in giant cell myocarditis.
“indicating that autoreactive T cells targeting heart antigens may play a crucial role in giant cell myocarditis.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [57]
Lewis rats immunized with cardiac myosin develop experimental autoimmune myocarditis with multinucleated giant cells, replicating clinical findings in giant cell myocarditis.
“The immunized rats developed EAM with multinucleated giant cells, replicating clinical findings in giant cell myocarditis.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [57]
Adoptive transfer of T cells isolated from cardiac myosin-immunized rats successfully induces myocarditis in recipients.
“the adoptive transfer of T cells isolated from the immunized rats successfully induced myocarditis in recipients”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [57]
In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions.
“In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions. 15-18,57,189,190,218”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [57]
These autoantibodies are generally not disease-specific and may not consistently induce the disease phenotype in murine models, indicating their limitations as diagnostic and therapeutic targets.
“However, these autoantibodies are generally not disease-specific and may not consistently induce the disease phenotype in murine models, indicating their limitations as diagnostic and therapeutic targets. 57,92,97,191”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [57]
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
- Authors
- Izumi, T., Kodama, M., & Shibata, A.
- Affiliations
- Niigata University (JP)
- Corresponding author
- Izumi, T.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-08-02
- Volume
- 12
- Issue
- suppl D
- Pages
- 166-168
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2016667776
- Cited by
- 29
- References
- 0
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- giant cell myocarditis, autoimmune myocarditis, cardiac myosin, Lewis rats, heart failure, myocardial necrosis, adoptive transfer, T cells
- MeSH terms
- Animals, Autoantibodies, Autoimmune Diseases, Guinea Pigs, Immunization, Mice, Inbred Strains, Myocarditis, Myosins, Rats, Inbred Lew, Giant Cells, Mice, Rats
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