Artificial intelligence in cardiovascular medicine: clinical applications
Open accessAbstract
Clinical medicine requires the integration of various forms of patient data including demographics, symptom characteristics, electrocardiogram findings, laboratory values, biomarker levels, and imaging studies. Decision-making on the optimal management should be based on a high probability that the envisaged treatment is appropriate, provides benefit, and bears no or little potential harm. To that end, personalized risk-benefit considerations should guide the management of individual patients to achieve optimal results. These basic clinical tasks have become more and more challenging with the massively growing data now available; artificial intelligence and machine learning (AI/ML) can provide assistance for clinicians by obtaining and comprehensively preparing the history of patients, analysing face and voice and other clinical features, by integrating laboratory results, biomarkers, and imaging. Furthermore, AI/ML can provide a comprehensive risk assessment as a basis of optimal acute and chronic care. The clinical usefulness of AI/ML algorithms should be carefully assessed, validated with confirmation datasets before clinical use, and repeatedly re-evaluated as patient phenotypes change. This review provides an overview of the current data revolution that has changed and will continue to change the face of clinical medicine radically, if properly used, to the benefit of physicians and patients alike.
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Generative AI models can analyze longitudinal data from patients with diabetes to predict cardiovascular events such as myocardial infarctions and strokes with greater accuracy than conventional risk assessment tools.
“Generative AI model can analyze longitudinal data from patients with diabetes to predict cardiovascular events, such as myocardial infarctions and strokes, with greater accuracy than conventional risk assessment tools (100).”
From Generative artificial intelligence in predictive analysis of diabetes and its complications: a narrative review (2025) · cites this paper as [100]
Cites
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy
Templin, C., Ghadri, J. R., Diekmann, J., Napp, L. C., Bataiosu, D. R., Jaguszewski, M., Cammann, V. L., Sarcon, A., Geyer, V., Neumann, C. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1406761 · Cited by 2,595 · see citing works
Self-citationJoshi, G., Jain, A., Araveeti, S. R., Adhikari, S., Garg, H., & Bhandari, M. (2024) · Electronics · doi:10.3390/electronics13030498 · Cited by 294 · see citing works
Artificial Intelligence for the Diagnosis of Heart Failure
Choi, D.-J., Park, J. J., Ali, T., & Lee, S. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0261-3 · Cited by 163 · see citing works
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Medicine, healthcare and the AI act: Gaps, challenges and future implications
Vardas, E. P., Marketou, M., & Vardas, P. E. (2025) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztaf041 · Cited by 60 · see citing works
Osonuga, A., Olawade, D. B., Gore, M., Rotifa, O. B., Egbon, E., Chinwah, V., & Boussios, S. (2025) · Annals of Translational Medicine · doi:10.21037/atm-25-62 · Cited by 4 · see citing works
Antoniades, C., & Chan, K. (2025) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztaf048 · Cited by 1 · see citing works
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- Authors
- Lüscher, T. F., Wenzl, F. A., D’Ascenzo, F., Friedman, P. A., & Antoniades, C.
- Affiliations
- King's College London (GB)
- National Health Service (GB)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Mayo Clinic (US)
- University of Oxford (GB)
- Corresponding author
- Lüscher, Thomas F
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2024-08-19
- Volume
- 45
- Issue
- 40
- Pages
- 4291-4304
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W4401700474
- Cited by
- 160
- References
- 3
- Citations by year
- 2026: 72 · 2025: 77 · 2024: 11
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning in Healthcare
- Keywords
- artificial intelligence, machine learning, clinical decision support, risk assessment, biomarkers, algorithm validation, personalized medicine, clinical phenotype
- MeSH terms
- Clinical Decision-Making, Machine Learning, Artificial Intelligence, Cardiology, Cardiovascular Diseases, Humans, Risk Assessment
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