Great debate: fire-and-forget beats personalized lipid-lowering treatment
Abstract
Key points in favour of or against fire-and-forget approach vs personalized therapy
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Passive lipid-management approaches may contribute to persistent undertreatment.
“passive approaches may contribute to persistent undertreatment”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [50]
Within pragmatic care models, incorporation of additional oral non-statin therapies may support more timely and acceptable treatment intensification.
“Within such pragmatic care models, incorporation of additional oral non-statin therapies may support more timely and acceptable treatment intensification [50].”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [50]
Structured monitoring and predefined escalation pathways may improve LDL-C goal attainment.
“structured monitoring and predefined escalation pathways may improve LDL-C goal attainment [50].”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [50]
Cites
Impact of Lipids on Cardiovascular Health
Ference, B. A., Graham, I., Tokgozoglu, L., & Catapano, A. L. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.06.046 · Cited by 511 · see citing works
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Cited by
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Systematic literature review on the real-world effectiveness and safety of bempedoic acid
Cicero, A. F. G., Cannon, C. P., Gautam, R., Anwar, S., Ghatak, A., Sarnes, E., Powell, H. A., Chhabra, R., & Jawla, S. (2026) · Atherosclerosis Plus · doi:10.1016/j.athplu.2026.100562 · Cited by 1 · see citing works
“In this context, recent debate contrasting “ fire-and-forget ” with personalized, goal-directed lipid strategies highlights that passive approaches may contribute to persistent undertreatment, whereas structured monitoring and predefined escalation pathways may improve LDL-C goal attainment [50].”
- Authors
- Tokgozoglu, L., Barkas, F., Ray, K. K., & Gianos, E.
- Affiliations
- Department of Cardiology, Hacettepe University , Cinnah Caddesi 24/11 Cankaya Ankara ,
- University of Ioannina (GR)
- Imperial College London (GB)
- Hofstra University (US)
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2025-10-03
- Volume
- 46
- Issue
- 44
- Pages
- 4751-4761
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W4414793081
- Cited by
- 4
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Keywords
- statins, hypercholesterolemia, cardiovascular risk management
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