Cited by 511Lipoproteins and Cardiovascular HealthCardiovascular Health and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

Impact of Lipids on Cardiovascular Health

Open access
Ference, Brian A., Graham, Ian, Tokgozoglu, Lale, Catapano, Alberico L.·2018·Journal of the American College of Cardiology

Abstract

People who maintain ideal cardiovascular heath have a low lifetime risk of cardiovascular disease. Therefore, encouraging people to achieve ideal cardiovascular health represents an important opportunity to improve the prevention of cardiovascular disease. However, preventing cardiovascular disease by promoting ideal cardiovascular health requires shifting the focus from treating disease after it develops to preventing cardiovascular events before they happen by slowing the progression of atherosclerosis. Because atherogenic lipoproteins play a central causal role in the initiation and progression of atherosclerosis, maintaining optimal lipid levels is necessary to achieve ideal cardiovascular health. This review describes the cumulative effect of lipid-carrying lipoproteins on the risk of cardiovascular disease, estimates the magnitude of the clinical benefit that can be achieved by maintaining optimal lipid levels, identifies the most effective timing for implementing strategies designed to achieve optimal lipid levels, and provides a clinical pathway to help people achieve the lipid levels necessary for ideal cardiovascular health.

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  1. Hingorani A, Humphries S. Nature's rando- mised trials. Lancet 2005;366:1906-8.
  2. Mensink RP. Effects of Saturated Fatty Acids on Serum Lipids and Lipoproteins: A Systematic Review and Regression Analysis. Geneva, Switzerland: World Health Organization, 2016.

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Authors
Ference, B. A., Graham, I., Tokgozoglu, L., & Catapano, A. L.
Affiliations
  • University of Cambridge (GB)
  • Trinity College Dublin (IE)
  • University of Milan (IT)
Corresponding author
Catapano, Alberico L.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2018-09
Volume
72
Issue
10
Pages
1141-1156
ISSN
0735-1097 (ISSN-L)
OpenAlex
W2889378692
Cited by
511
References
62
Citations by year
2026: 65 · 2025: 75 · 2024: 82 · 2023: 80 · 2022: 68 · 2021: 76 · 2020: 35 · 2019: 29 · 2018: 1
FWCI
7.83
Type
journal article
Language
en
Open access
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
ideal cardiovascular health, cardiovascular disease prevention, atherosclerosis, atherogenic lipoproteins, serum lipids, cardiovascular risk, care pathways
MeSH terms
Hypolipidemic Agents, Cardiovascular Diseases, Diet, Health Promotion, Humans, Lipids, Cholesterol, LDL, Primary Prevention, Genetic Variation, Exercise, Disease Progression, Genetic Predisposition to Disease, Atherosclerosis, Plaque, Atherosclerotic

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