CoChat
Sign Up
Cited by 171Cardiac Valve Diseases and TreatmentsCardiovascular Function and Risk FactorsCardiac Imaging and Diagnostics

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Left atrial remodelling in mitral regurgitation—methodologic approach, physiological determinants, and outcome implications: a prospective quantitative Doppler-echocardiographic and electron beam-computed tomographic study

Messika-Zeitoun, D., Bellamy, M., Avierinos, J.-F., Breen, J., Eusemann, C., Rossi, A., Behrenbeck, T., Scott, C., Tajik, J. A., Enriquez-Sarano, M.·2007·European Heart Journal
DOI 10.1093/eurheartj/ehm199
Open this paper in CoChat — free account

Abstract

AIMS: To define accurate and normal range of echocardiographic left atrial (LA) volume measurement and to assess the prevalence, determinants, and outcome implications of LA enlargement in mitral regurgitation (MR). METHODS AND RESULTS: We prospectively compared LA volume obtained simultaneously by electron beam-computed tomography (EBCT) and by four echocardiographic methods in 33 test patients. Accurate echocardiographic LA volume measurements were obtained only by biplane area-length method with vertical longitudinal-length (r = 0.95, P < 0.0001; 145 +/- 57 vs. 143 +/- 55 mL, P = 0.57). Using this method, the normal range in 100 normal subjects, the physiological determinants and outcome implications of LA enlargement in 320 patients with organic MR were analysed. In normal subjects, indexed to body surface area, LA index (27 +/- 6 mL/m(2)) was not influenced by age or gender and values > or = 40 mL/m(2) were beyond the upper limit of normal. In MR, the most powerful determinants of LA enlargement were higher regurgitant volume (RVol) and atrial fibrillation (AF) (P < 0.0001), followed by older age, female gender, higher left ventricular end-systolic volume, and mass (all P < 0.001). After diagnosis in sinus rhythm, LA index > or = 40 mL/m(2) predicted superiorly and independently to LA diameter the occurrence of AF [adjusted RR 1.48 (1.06-2.16), P < 0.01] and the combined endpoint of death or need for mitral surgery [adjusted RR 1.61 (1.3-2.0), P < 0.0001]. CONCLUSION: LA remodelling can be accurately assessed by echocardiography and LA index > or = 40 mL/m(2) is beyond the normal range. In organic MR, higher LA index is the combined result of multiple physiological effects, provides independent prognostic information, and therefore should be part of a comprehensive echocardiographic examination.

Overview

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehm199

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 171

Related

See all

Metadata

Authors
Messika-Zeitoun, D., Bellamy, M., Avierinos, J.-F., Breen, J., Eusemann, C., Rossi, A., Behrenbeck, T., Scott, C., Tajik, J. A., & Enriquez-Sarano, M.
Affiliations
  • Mayo Clinic (US)
  • University of Verona (IT)
Corresponding author
Enriquez-Sarano, M.
ORCID
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2007-03-06
Volume
28
Issue
14
Pages
1773-1781
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/ehm199
OpenAlex
W2071824807
Cited by
171
References
39
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 4 · 2014: 18 · 2013: 14 · 2012: 9
FWCI
4.62
Type
journal article
Language
en
Open access
closed
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl064928-02)
  • National Heart, Lung, and Blood Institute (HL-64928)
  • National Center for Research Resources (M01RR000585)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
left atrial remodeling, mitral regurgitation, left atrial volume, atrial fibrillation, regurgitant volume, left ventricular mass, left ventricular end-systolic volume, electron beam computed tomography, prognosis
MeSH terms
Aged, Blood Flow Velocity, Electrocardiography, Female, Heart Atria, Humans, Male, Middle Aged, Mitral Valve Insufficiency, Prospective Studies, Tomography, Emission-Computed, Ultrasonography, Cohort Studies, Atrial Function, Left

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review