Foetal echocardiographic assessment of tetralogy of Fallot and post-natal outcome
Abstract
AIMS: Outcome of foetuses diagnosed with tetralogy of Fallot (TOF) or pulmonary atresia with ventricular septal defect (PA-VSD) and the reliability of foetal echocardiography to predict post-natal surgical outcome. METHODS AND RESULTS: Outcome of 218 foetuses having been diagnosed with TOF (n = 153) or PA-VSD (n = 65) was reviewed. Abnormal karyotyping, 22q11 deletion, and extracardiac anomalies were found, respectively, in 11, 18, and 46%. Pregnancy was terminated in 75 cases (34%), and in three cases foetuses died in utero. Presence or absence and confluence of PA branches were confirmed after birth or pregnancy termination in all but five (5%) cases. Main pulmonary trunk (MPA) was incorrectly described in 11 (10%) cases and major aorto-pulmonary collateral arteries in 16 (13%) cases. Among live born infants, 110 (88%) were operated and 92 (74%) underwent complete repair in the first year of life. Size of confluent PAs and presence of MPA were related to the probability of having a complete repair in the first year of life. CONCLUSION: Foetal diagnosis of TOF and PA-VSD has a major impact on pregnancy outcome, as associated anomalies are frequently found. Pre-natally determined size of PA branches and presence of MPA are good predictors of complete repair in the first year of life.
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Prenatal detection of ToF has less effect on postnatal presurgical mortality.
“Prenatal detection of ToF has less effect on the postnatal presurgical mortality of these infants.12”
From The effect of the introduction of the three‐vessel view on the detection rate of transposition of the great arteries and tetralogy of <scp>Fallot</scp> (2018) · cites this paper as [12]
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- Authors
- Kaguelidou, F., Fermont, L., Boudjemline, Y., Le Bidois, J., Batisse, A., & Bonnet, D.
- Affiliations
- Hôpital Necker-Enfants Malades (FR)
- Corresponding author
- Bonnet, D.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-18
- Volume
- 29
- Issue
- 11
- Pages
- 1432-1438
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2156349344
- Cited by
- 46
- References
- 18
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 6 · 2021: 4 · 2019: 5 · 2018: 3 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Keywords
- tetralogy of Fallot, pulmonary atresia with ventricular septal defect, prenatal diagnosis, complete repair, 22q11.2 deletion, pregnancy outcomes, fetal karyotyping, extracardiac anomalies
- MeSH terms
- Adolescent, Adult, Echocardiography, Female, Heart Septal Defects, Ventricular, Humans, Male, Middle Aged, Pregnancy, Pregnancy Outcome, Tetralogy of Fallot, Ultrasonography, Prenatal, Pulmonary Atresia, Early Diagnosis
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