Cited by 46Congenital Heart Disease StudiesCongenital heart defects researchCardiovascular Conditions and Treatments

Foetal echocardiographic assessment of tetralogy of Fallot and post-natal outcome

Kaguelidou, F., Fermont, L., Boudjemline, Y., Le Bidois, J., Batisse, A., Bonnet, D.·2008·European Heart Journal

Abstract

AIMS: Outcome of foetuses diagnosed with tetralogy of Fallot (TOF) or pulmonary atresia with ventricular septal defect (PA-VSD) and the reliability of foetal echocardiography to predict post-natal surgical outcome. METHODS AND RESULTS: Outcome of 218 foetuses having been diagnosed with TOF (n = 153) or PA-VSD (n = 65) was reviewed. Abnormal karyotyping, 22q11 deletion, and extracardiac anomalies were found, respectively, in 11, 18, and 46%. Pregnancy was terminated in 75 cases (34%), and in three cases foetuses died in utero. Presence or absence and confluence of PA branches were confirmed after birth or pregnancy termination in all but five (5%) cases. Main pulmonary trunk (MPA) was incorrectly described in 11 (10%) cases and major aorto-pulmonary collateral arteries in 16 (13%) cases. Among live born infants, 110 (88%) were operated and 92 (74%) underwent complete repair in the first year of life. Size of confluent PAs and presence of MPA were related to the probability of having a complete repair in the first year of life. CONCLUSION: Foetal diagnosis of TOF and PA-VSD has a major impact on pregnancy outcome, as associated anomalies are frequently found. Pre-natally determined size of PA branches and presence of MPA are good predictors of complete repair in the first year of life.

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Crossref · 10.1093/eurheartj/ehn194

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Authors
Kaguelidou, F., Fermont, L., Boudjemline, Y., Le Bidois, J., Batisse, A., & Bonnet, D.
Affiliations
Hôpital Necker-Enfants Malades (FR)
Corresponding author
Bonnet, D.
Venue
European Heart Journal
Published
2008-01-18
Volume
29
Issue
11
Pages
1432-1438
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W2156349344
Cited by
46
References
18
Citations by year
2025: 1 · 2023: 3 · 2022: 6 · 2021: 4 · 2019: 5 · 2018: 3 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
2.96
Type
journal article
Language
en
Open access
closed
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
Keywords
tetralogy of Fallot, pulmonary atresia with ventricular septal defect, prenatal diagnosis, complete repair, 22q11.2 deletion, pregnancy outcomes, fetal karyotyping, extracardiac anomalies
MeSH terms
Adolescent, Adult, Echocardiography, Female, Heart Septal Defects, Ventricular, Humans, Male, Middle Aged, Pregnancy, Pregnancy Outcome, Tetralogy of Fallot, Ultrasonography, Prenatal, Pulmonary Atresia, Early Diagnosis

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