The DOI matches its Crossref record; 76 of the 78 references it cites were found in a registry or an index.
Behavioural interventions for smoking cessation: a meta-analysis of randomized controlled trials
Abstract
AIMS: Widely varying estimates of treatment effects have been reported in randomized controlled trials (RCTs) investigating the efficacy of behavioural interventions for smoking cessation. Previous meta-analyses investigating behavioural interventions have important limitations and do not include recently published RCTs. We undertook a meta-analysis of RCTs to synthesize the treatment effects of four behavioural interventions, including minimal clinical intervention (brief advice from a healthcare worker), and intensive interventions, including individual, group, and telephone counselling. METHODS AND RESULTS: We searched the CDC Tobacco Information and Prevention, Cochrane Library, EMBASE, Medline, and PsycINFO databases. We included only RCTs that reported biochemically validated smoking cessation outcomes at 6 and/or 12 months after the target quit date. Outcomes were aggregated using hierarchical Bayesian random-effects models. We identified 50 RCTs, which randomized n = 26 927 patients (minimal clinical intervention: 9 RCTs, n = 6456; individual counselling: 23 RCTs, n = 8646; group counselling: 12 RCTs, n = 3600; telephone counselling: 10 RCTs, n = 8225). The estimated mean treatment effects were minimal clinical intervention [odds ratio (OR) 1.50, 95% credible interval (CrI) 0.84-2.78], individual counselling (OR 1.49, 95% CrI 1.08-2.07), group counselling (OR 1.76, 95% CrI 1.11-2.93), and telephone counselling (OR 1.58, 95% CrI 1.15-2.29). CONCLUSION: Intensive behavioural interventions result in substantial increases in smoking abstinence compared with control. Although minimal clinical intervention may increase smoking abstinence, there is insufficient evidence to draw strong conclusions regarding its efficacy.
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“In a review of 50 randomised controlled trials 22 and another review of 23 studies since January 2000, 23 a group format for a behavioural intervention was not found to be significantly different from an individual format”
From Evaluating Long-term Outcomes of NHS Stop Smoking Services (ELONS): a prospective cohort study (2015) · cites this paper as [22]
Citations
Cites
Gelman, A., Carlin, J. B., Stern, H. S., & Rubin, D. B. (2003) · doi:10.1201/9780429258480 · Cited by 27,276
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Nicotine replacement therapy for smoking cessation
Stead, L. F., Perera, R., Bullen, C., Mant, D., Hartmann‐Boyce, J., Cahill, K., & Lancaster, T. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000146.pub4 · Cited by 2,564
Physician advice for smoking cessation
Stead, L. F., Buitrago, D., Preciado, N., Sanchez, G., Hartmann-Boyce, J., & Lancaster, T. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000165.pub4 · Cited by 1,955
Biochemical verification of tobacco use and cessation
Benowitz, N. L., III, P. J., Ahijevych, K., Jarvis, M. J., Hall, S., LeHouezec, J., Hansson, A., Lichtenstein, E., Henningfield, J., Tsoh, J., et al. (2002) · Nicotine & Tobacco Research · doi:10.1080/14622200210123581 · Cited by 1,800
Telephone counselling for smoking cessation
Stead, L. F., Hartmann‐Boyce, J., Perera, R., & Lancaster, T. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002850.pub3 · Cited by 1,030
Individual behavioural counselling for smoking cessation
Lancaster, T., & Stead, L. F. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001292.pub2 · Cited by 1,015
Nicotine replacement therapy for smoking cessation
Silagy, C., Lancaster, T., Stead, L., Mant, D., & Fowler, G. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000146.pub2 · Cited by 972
Group behaviour therapy programmes for smoking cessation
Stead, L. F., Carroll, A. J., & Lancaster, T. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001007.pub3 · Cited by 825
Antidepressants for smoking cessation
Hughes, J., Stead, L., & Lancaster, T. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000031 · Cited by 683
Cited by
Sorted by citations
Pilot study of the 5-HT 2A R agonist psilocybin in the treatment of tobacco addiction
Johnson, M. W., Garcia-Romeu, A., Cosimano, M. P., & Griffiths, R. R. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114548296 · Cited by 914
“…scope of smoking-related mortality, and the modest success rates of approved smoking cessation treatments (Cahill et al., 2014; Gonzales et al., 2006; Jorenby et al., 2006; Mottillo et al., 2009), the novel approach presented here warrants further investigation with a randomized controlled trial.”
BackgroundLong-term follow-up of psilocybin-facilitated smoking cessation
Johnson, M. W., Garcia-Romeu, A., & Griffiths, R. R. (2017) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2016.1170135 · Cited by 696
“Additionally, this questionnaire included three items asking participants to rate: (1) the overall personal meaning, (2) spiritual significance, and (3) effects on well-being or life satisfaction attributed to psilocybin experiences or contemplation of those experiences.”
Unemployment and Substance Use: A Review of the Literature (1990-2010)
Henkel, D. (2011) · Current Drug Abuse Reviewse · doi:10.2174/1874473711104010004 · Cited by 590
“Literature searches revealed numerous systematic reviews and meta-analyses that analyzed pharmacotherapeutical, behavioral and psychosocial interventions for smoking cessation [164-167], but none of these studies considered job loss or unemployment as a potential predictor.”
BackgroundPsilocybin-Occasioned mystical experiences in the treatment of tobacco addiction.
Garcia-Romeu, A., Griffiths, R., & Johnson, M. (2015) · Current Drug Abuse Reviews · doi:10.2174/1874473708666150107121331 · Cited by 476
“However, it is noteworthy that the most successful current treatments for smoking cessation generally show far less efficacy, with typical abstinence rates below 35% at 6 months [23-24].”
BackgroundMindfulness training for smoking cessation: Results from a randomized controlled trial
Brewer, J. A., Mallik, S., Babuscio, T. A., Nich, C., Johnson, H. E., Deleone, C. M., Minnix-Cotton, C. A., Byrne, S. A., Kober, H., Weinstein, A. J., et al. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.05.027 · Cited by 383
“These findings are encouraging as behavioral treatments have shown little overall improvement in cessation rates over the past 30 years (Mottillo et al., 2009; Shiffman, 1993).”
ResultInfluential
Metadata
- Authors
- Mottillo, S., Filion, K. B., Bélisle, P., Joseph, L., Gervais, A., O'Loughlin, J., Paradis, G., Pihl, R., Pilote, L., Rinfret, S., Tremblay, M., & Eisenberg, M. J.
- Affiliations
- Jewish General Hospital (CA)
- McGill University Health Centre (CA)
- McGill University (CA)
- Corresponding author
- Eisenberg, Mark J.
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12-24
- Volume
- 30
- Issue
- 6
- Pages
- 718-730
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2025716661
- Cited by
- 171
- References
- 78
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 14 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 10 · 2017: 11 · 2016: 9 · 2015: 18 · 2014: 13 · 2013: 19 · 2012: 14
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Applied Psychology › Behavioral Health and Interventions
- Keywords
- smoking cessation, behavioral interventions, brief advice, individual counseling, group counseling, telephone counseling, smoking abstinence, treatment efficacy
- MeSH terms
- Smoking Prevention, Behavior Therapy, Female, Humans, Male, United States, Randomized Controlled Trials as Topic, Smoking Cessation
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