The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Diastolic dysfunction and mortality in severe sepsis and septic shock
Open accessAbstract
AIMS: Systolic dysfunction in septic shock is well recognized and, paradoxically, predicts better outcome. In contrast, diastolic dysfunction is often ignored and its role in determining early mortality from sepsis has not been adequately investigated. METHODS AND RESULTS: A cohort of 262 intensive care unit patients with severe sepsis or septic shock underwent two echocardiography examinations early in the course of their disease. All clinical, laboratory, and survival data were prospectively collected. Ninety-five (36%) patients died in the hospital. Reduced mitral annular e'-wave was the strongest predictor of mortality, even after adjusting for the APACHE-II score, low urine output, low left ventricular stroke volume index, and lowest oxygen saturation, the other independent predictors of mortality (Cox's proportional hazards: Wald = 21.5, 16.3, 9.91, 7.0 and 6.6, P< 0.0001, <0.0001, 0.002, 0.008, and 0.010, respectively). Patients with systolic dysfunction only (left ventricular ejection fraction ≤50%), diastolic dysfunction only (e'-wave <8 cm/s), or combined systolic and diastolic dysfunction (9.1, 40.4, and 14.1% of the patients, respectively) had higher mortality than those with no diastolic or systolic dysfunction (hazard ratio = 2.9, 6.0, 6.2, P= 0.035, <0.0001, <0.0001, respectively) and had significantly higher serum levels of high-sensitivity troponin-T and N-terminal pro-B-type natriuretic peptide (NT-proBNP). High-sensitivity troponin-T was only minimally elevated, whereas serum levels of NT-proBNP were markedly elevated [median (inter-quartile range): 0.07 (0.02-0.17) ng/mL and 5762 (1001-15 962) pg/mL, respectively], though both predicted mortality even after adjusting for highest creatinine levels (Wald = 5.8, 21.4 and 2.3, P= 0.015, <0.001 and 0.13). CONCLUSION: Diastolic dysfunction is common and is a major predictor of mortality in severe sepsis and septic shock.
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Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
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Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
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Recommendations for the evaluation of left ventricular diastolic function by echocardiography
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Profound but Reversible Myocardial Depression in Patients with Septic Shock
PARKER, M. M., SHELHAMER, J. H., BACHARACH, S. L., GREEN, M. V., NATANSON, C., FREDERICK, T. M., DAMSKE, B. A., & PARRILLO, J. E. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-4-483 · Cited by 1,585
Cited by
Beesley, S. J., Weber, G., Sarge, T., Nikravan, S., Grissom, C. K., Lanspa, M. J., Shahul, S., & Brown, S. M. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000002851 · Cited by 528
Frankel, H. L., Kirkpatrick, A. W., Elbarbary, M., Blaivas, M., Desai, H., Evans, D., Summerfield, D. T., Slonim, A., Breitkreutz, R., Price, S., et al. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001216 · Cited by 494
Levitov, A., Frankel, H. L., Blaivas, M., Kirkpatrick, A. W., Su, E., Evans, D., Summerfield, D. T., Slonim, A., Breitkreutz, R., Price, S., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001847 · Cited by 440
Ehrman, R. R., Sullivan, A. N., Favot, M. J., Sherwin, R. L., Reynolds, C. A., Abidov, A., & Levy, P. D. (2018) · Critical Care · doi:10.1186/s13054-018-2043-8 · Cited by 284
Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis
Sanfilippo, F., Corredor, C., Fletcher, N., Landesberg, G., Benedetto, U., Foex, P., & Cecconi, M. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3748-7 · Cited by 277
Self-citation
Metadata
- Authors
- Landesberg, G., Gilon, D., Meroz, Y., Georgieva, M., Levin, P. D., Goodman, S., Avidan, A., Beeri, R., Weissman, C., Jaffe, A. S., & Sprung, C. L.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-11
- Volume
- 33
- Issue
- 7
- Pages
- 895-903
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2130621776
- Cited by
- 472
- References
- 40
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- green
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