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Cited by 1,401

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

Open access
Paneni, Francesco, Beckman, Joshua A., Creager, Mark A., Cosentino, Francesco·2013·European Heart Journal
DOI 10.1093/eurheartj/eht149
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Abstract

Hyperglycemia and insulin resistance are key players in the development of atherosclerosis and its complications. A large body of evidence suggest that metabolic abnormalities cause overproduction of reactive oxygen species (ROS). In turn, ROS, via endothelial dysfunction and inflammation, play a major role in precipitating diabetic vascular disease. A better understanding of ROS-generating pathways may provide the basis to develop novel therapeutic strategies against vascular complications in this setting. Part I of this review will focus on the most current advances in the pathophysiological mechanisms of vascular disease: (i) emerging role of endothelium in obesity-induced insulin resistance; (ii) hyperglycemia-dependent microRNAs deregulation and impairment of vascular repair capacities; (iii) alterations of coagulation, platelet reactivity, and microparticle release; (iv) epigenetic-driven transcription of ROS-generating and proinflammatory genes. Taken together these novel insights point to the development of mechanism-based therapeutic strategies as a promising option to prevent cardiovascular complications in diabetes.

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Crossref · 10.1093/eurheartj/eht149

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Metadata

Authors
Paneni, F., Beckman, J. A., Creager, M. A., & Cosentino, F.
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2013-05-02
Volume
34
Issue
31
Pages
2436-2443
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/eht149
OpenAlex
W2158106881
Cited by
1,401
References
72
FWCI
65.90
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. https://app.cochat.ai/papers/10.1093/eurheartj/eht149
The paper
Paneni, F., Beckman, J. A., Creager, M. A., & Cosentino, F. (2013). Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. European Heart Journal. https://doi.org/10.1093/eurheartj/eht149

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.