The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Early management of atrial fibrillation to prevent cardiovascular complications
Abstract
Atrial fibrillation (AF) is generally considered a progressive disease, typically evolving from paroxysmal through persistent to 'permanent' forms, a process attributed to electrical and structural remodelling related to both the underlying disease and AF itself. Medical treatment has yet to demonstrate clinical efficacy in preventing progression. Large clinical trials performed to date have failed to show benefit of rhythm control compared with rate control, but these trials primarily included patients at late stages in the disease process. One possible explanation is that intervention at only an early stage of progression may improve prognosis. Evolving observations about the progressive nature of AF, along with the occurrences of major complications such as strokes upon AF presentation, led to the notion that earlier and more active approaches to AF detection, rhythm-reversion, and maintenance of sinus rhythm may be a useful strategy in AF management. Approaches to early and sustained rhythm control include measures that prevent development of the AF substrate, earlier catheter ablation, and novel antiarrhythmic drugs. Improved classifications of AF mechanism, pathogenesis, and remodelling may be helpful to enable patient-specific pathophysiological diagnosis and therapy. Potential novel therapeutic options under development include microRNA-modulation, heatshock protein inducers, agents that influence Ca(2+) handling, vagal stimulators, and more aggressive mechanism-based ablation strategies. In this review, of research into the basis and management of AF in acute and early settings, it is proposed that progression from paroxysmal to persistent AF can be interrupted, with potentially favourable prognostic impact.
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Cites
A comparison of rate control and rhythm control in patients with atrial fibrillation
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Subclinical atrial fibrillation and the risk of stroke
Healey, J. S., Connolly, S. J., Gold, M. R., Israel, C. W., Van Gelder, I. C., Capucci, A., Lau, C. P., Fain, E., Yang, S., Bailleul, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1105575 · Cited by 2,100
Rhythm control versus rate control for atrial fibrillation and heart failure
Roy, D., Talajic, M., Nattel, S., Wyse, D. G., Dorian, P., Lee, K. L., Bourassa, M. G., Arnold, J. M. O., Buxton, A. E., Camm, A. J., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708789 · Cited by 1,585
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.016 · Cited by 1,456
Self-citationExcessive Supraventricular Ectopic Activity and Increased Risk of Atrial Fibrillation and Stroke
Binici, Z., Intzilakis, T., Nielsen, O. W., Køber, L., & Sajadieh, A. (2010) · Circulation · doi:10.1161/circulationaha.109.874982 · Cited by 379
Endurance sport practice as a risk factor for atrial fibrillation and atrial flutter
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Bloch Thomsen, P. E., Jons, C., Raatikainen, M. J. P., Moerch Joergensen, R., Hartikainen, J., Virtanen, V., Boland, J., Anttonen, O., Gang, U. J., Hoest, N., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.902148 · Cited by 285
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Cited by
Atrial Remodeling and Atrial Fibrillation
Nattel, S., & Harada, M. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.555 · Cited by 736
Self-citationProgression of Atrial Fibrillation after Cryoablation or Drug Therapy
Andrade, J. G., Deyell, M. W., Macle, L., Wells, G. A., Bennett, M., Essebag, V., Champagne, J., Roux, J.-F., Yung, D., Skanes, A., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2212540 · Cited by 385
Rienstra, M., Hobbelt, A. H., Alings, M., Tijssen, J. G. P., Smit, M. D., Brügemann, J., Geelhoed, B., Tieleman, R. G., Hillege, H. L., Tukkie, R., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx739 · Cited by 313
Calvo, N., Ramos, P., Montserrat, S., Guasch, E., Coll-Vinent, B., Domenech, M., Bisbal, F., Hevia, S., Vidorreta, S., Borras, R., et al. (2016) · Europace · doi:10.1093/europace/euv216 · Cited by 153
Self-citationDiagnosis, pathophysiology, and management of exercise-induced arrhythmias
Guasch, E., & Mont, L. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.173 · Cited by 134
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Metadata
- Authors
- Nattel, S., Guasch, E., Savelieva, I., Cosio, F. G., Valverde, I., Halperin, J. L., Conroy, J. M., Al-Khatib, S. M., Hess, P. L., Kirchhof, P., De Bono, J., Lip, G. Y. H., Banerjee, A., Ruskin, J., Blendea, D., & Camm, A. J.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-02-16
- Volume
- 35
- Issue
- 22
- Pages
- 1448-1456
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W1970242617
- Cited by
- 273
- References
- 9
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Early management of atrial fibrillation to prevent cardiovascular complications. https://app.cochat.ai/papers/10.1093/eurheartj/ehu028
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- Nattel, S., Guasch, E., Savelieva, I., Cosio, F. G., Valverde, I., Halperin, J. L., Conroy, J. M., Al-Khatib, S. M., Hess, P. L., Kirchhof, P., De Bono, J., Lip, G. Y. H., Banerjee, A., Ruskin, J., Blendea, D., & Camm, A. J. (2014). Early management of atrial fibrillation to prevent cardiovascular complications. European Heart Journal. https://doi.org/10.1093/eurheartj/ehu028
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
