The 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD
Abstract
The most clinically relevant new aspects of the 2019 version of the ESC Guidelines compared with the previous version published in 2013 relate to: ... The prevalence of diabetes continues to increase, with 60 million thought to have diabetes in Europe in 2017 and predictions of more than 600 million individuals with diabetes worldwide by 2045. These numbers carry a huge burden of morbidity and mortality with a high prevalence of microvascular disease affecting the eyes, nerves, and kidneys and macrovascular disease leading to CV, cerebrovascular, and peripheral vascular disease. The combination of diabetes, CKD, hypertension, and dyslipidaemia make a potent contribution to the development of CV disease and the 2019 guidelines pay particular attention to the new information from clinical trials that address the management of these issues. Whilst updating our recommendations has been a key element in the new guidelines we have continued to emphasize the importance of making individualized care decisions in collaboration with other healthcare workers and informed patients as outlined in the 2013 guidelines.
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The American Diabetes Association, the American College of Cardiology, and the European Society of Cardiology recommend that patients with type 2 diabetes with established or at risk of atherosclerotic cardiovascular disease, chronic kidney disease, or heart failure be prescribed an SGLT2i or GLP-1 RA, irrespective of glycemic control or metformin use.
“These findings prompted the American Diabetes Association,2 the American College of Cardiology,3 and the European Society of Cardiology4 to recommend that patients with type 2 diabetes with established or at risk of atherosclerotic cardiovascular disease, chronic kidney disease, or heart failure, be prescribed an SGLT2i or GLP-1 RA, irrespective of glycemic control or metformin use.”
From Race and ethnicity and pharmacy dispensing of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes (2024) · cites this paper as [4]
In general, comorbidities were independently associated with pharmacy dispensing of these drugs, which aligns with national guidelines.
“In general, comorbidities were independently associated with pharmacy dispensing of these drugs, which aligns with national guidelines.2, 3, 4”
From Race and ethnicity and pharmacy dispensing of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes (2024) · cites this paper as [4]
Cited by
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Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management
Ma, C.-X., Ma, X.-N., Guan, C.-H., Li, Y.-D., Mauricio, D., & Fu, S.-B. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01516-6 · Cited by 464 · see citing works
Bertoccini, L., & Baroni, M. G. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2020_494 · Cited by 49 · see citing works
Nicholls, S. J., Nelson, M., Astley, C., Briffa, T., Brown, A., Clark, R., Colquhoun, D., Gallagher, R., Hare, D. L., Inglis, S., et al. (2020) · Heart, Lung and Circulation · doi:10.1016/j.hlc.2020.04.007 · Cited by 43 · see citing works
Rodriguez, L. A., Finertie, H., Neugebauer, R. S., Gosiker, B., Thomas, T. W., Karter, A. J., Gilliam, L. K., Oshiro, C., An, J., Simonson, G., et al. (2024) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2024.100759 · Cited by 31 · see citing works
Yang, R., Xu, H., Pedersen, N. L., Li, X., Yu, J., Bao, C., Qi, X., & Xu, W. (2021) · Diabetologia · doi:10.1007/s00125-020-05324-z · Cited by 28 · see citing works
- Authors
- Grant, P. J., & Cosentino, F.
- Affiliations
- University of Leeds (GB)
- Karolinska University Hospital (SE)
- Corresponding author
- Grant, Peter J
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-10-14
- Volume
- 40
- Issue
- 39
- Pages
- 3215-3217
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2980162794
- Cited by
- 200
- References
- 0
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 20 · 2023: 32 · 2022: 37 · 2021: 54 · 2020: 30 · 2019: 4
- FWCI
- 25.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- diabetes mellitus, prediabetes, cardiovascular disease, cardiovascular risk management, chronic kidney disease, hypertension, dyslipidemia, microvascular complications, macrovascular complications, individualized care
- MeSH terms
- Anticoagulants, Aspirin, Atrial Fibrillation, Blood Pressure, Cardiovascular Diseases, Diabetes Mellitus, Humans, Hypoglycemic Agents, Cholesterol, LDL, Prediabetic State, Risk Factors, Practice Guidelines as Topic
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