Discordance of apolipoprotein B with low-density lipoprotein cholesterol or non-high-density lipoprotein cholesterol and coronary atherosclerosis
Abstract
Aims High level of apolipoprotein B (Apo B) is associated with incident subclinical atherosclerosis. The present study evaluated the associations between discordant Apo B with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and coronary atherosclerotic burden. Methods and results This study enrolled 3043 participants aged 50-75 years from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study that was conducted in the community in Lishui City, China. Discordant Apo B with LDL-C and non-HDL-C were defined by residuals and medians. Coronary atherosclerotic burden was evaluated by segment involvement score (SIS) and segment stenosis score (SSS) which were determined by computed tomography angiography. We performed discordance analyses examining associations of discordant Apo B with LDL-C or non-HDL-C with the coronary atherosclerotic burden. The mean age of participants was 61.2 ± 6.7 years, 53.6% were females. Participants with discordant high Apo B relative to non-HDL-C were at higher odds of plaques [odds ratio (OR), 1.30; 95% confidence interval (CI), 1.08-1.57], SIS [common odds ratio (cOR), 1.35; 95% CI, 1.14-1.60], and SSS (cOR, 1.40; 95% CI, 1.18-1.67) compared with concordant group. However, discordantly low Apo B with non-HDL-C was associated with decreased odds of the coronary atherosclerotic plaques and its burden. Similar results were shown for discordant analyses for Apo B with LDL…
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apoB is a more accurate measure of the adequacy of lipid-lowering therapy than LDL-C or non-HDL-C.
“given that apoB is a more accurate measure of the adequacy of lipid-lowering therapy than LDL-C or non-HDL-C,1,3–13,27”
From Discordance among apoB, non-high-density lipoprotein cholesterol, and triglycerides: implications for cardiovascular prevention (2024) · cites this paper as [9]
All reports since 2019, with one exception, including observational studies and randomized clinical trials, have confirmed that apoB is a more accurate marker of cardiovascular risk than LDL-C or non-HDL-C.
“Moreover, all reports since then, with one exception,2 including observational studies and randomized clinical trials,3–13 have confirmed that apoB is a more accurate marker of cardiovascular risk than LDL-C or non-HDL-C, reinforcing the validity of the evaluation by the 2019 EAS/ESC Guidelines as to the superiority of apoB.”
From Discordance among apoB, non-high-density lipoprotein cholesterol, and triglycerides: implications for cardiovascular prevention (2024) · cites this paper as [9]
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Sniderman, A. D., Dufresne, L., Pencina, K. M., Bilgic, S., Thanassoulis, G., & Pencina, M. J. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae258 · Cited by 117 · see citing works
- Authors
- Su, X., Cai, X., Pan, Y., Sun, J., Jing, J., Wang, M., Meng, X., Wang, Y., Wei, T., & He, Y.
- Affiliations
- Capital Medical University (CN)
- Zhejiang University (CN)
- Corresponding author
- Wei, Tiemin
- He, Yan
- ORCID
- Venue
- European Journal of Preventive Cardiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-09-27
- Volume
- 29
- Issue
- 18
- Pages
- 2349-2358
- ISSN
- 2047-4873 (ISSN-L)
- 2047-4881
- OpenAlex
- W4297266089
- Cited by
- 34
- References
- 7
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 2
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Preventive Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82073648, 81971091)
- Ministry of Science and Technology of the People’s Republic of China (2017YFC1310902, 2018YFC1311706, 2016YFC0901002, 2017YFC1310901, 2017YFC1307905, 2018YFC1312801)
- Beijing Hospitals Authority Youth Programme (QML20190501)
- Beijing Science and Technology Plan
- Brain Science and Research North Science Center Project (Z181100001518005)
- the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB39000000)
- Lishui Science & Technology Bureau (2019ZDYF18)
- AstraZeneca Investment (China) Co., Ltd (CSA2017KY007)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- apolipoprotein B, LDL cholesterol, non-HDL cholesterol, coronary artery disease, coronary atherosclerotic burden, coronary plaque, segment involvement score, CT angiography, primary prevention, middle-aged and older adults
- MeSH terms
- Aged, Apolipoproteins B, Cholesterol, Coronary Artery Disease, Female, Humans, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Atherosclerosis, Plaque, Atherosclerotic
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