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Cited by 30Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlVestibular and auditory disorders

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Impaired arterial baroreflex function before nitrate-induced vasovagal syncope during head-up tilt test

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Iacoviello, M., Guida, P., Forleo, C., Sorrentino, S., D'Alonzo, L., Favale, S.·2008·Europace
DOI 10.1093/europace/eun217
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Abstract

AIMS: The aim of this study was to evaluate arterial baroreflex control of heart rate immediately before head-up tilt test (HUT)-induced vasovagal syncope (VVS). METHODS AND RESULTS: We enrolled 97 otherwise healthy subjects with recurrent unexplained syncope. After 10 min of rest in supine position, they underwent a passive HUT potentiated with nitroglycerin administration after 20 min. Beat-to-beat heart rate and systolic blood pressure were continuously recorded. Sequence method was used to measure two complementary parameters reflecting arterial baroreflex control of heart rate: the baroreflex sensitivity (BRS) and the baroreflex effectiveness index (BEI). Twenty-one patients fainted before nitrate administration (HUT+) and 37 after nitrate administration (NTG+). Immediately before syncope, the NTG+ patients showed significantly lower BRS values than those observed at the end of the test in the patients without syncope (5.5 +/- 2.8 vs. 7.7 +/- 3.4 ms/mmHg; P = 0.004) and a significantly lower BEI (30 +/- 20% vs. 53 +/- 24%; P < 0.001). The HUT+ patients did not show any significant differences in BRS and BEI before syncope from the values observed during the corresponding tilt period in the other groups. CONCLUSION: A significant depression in BRS and BEI occurs immediately before syncope in patients who faint after nitrate administration, thus suggesting that arterial baroreflex dysfunction plays a role in mediating nitrate-induced VVS.

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  • Reductions in baroreflex sensitivity have been demonstrated in presyncopal states by some studies, although the literature is not consistent, probably due to methodological differences.

    “Indeed, reductions in baroreflex sensitivity have been demonstrated in presyncopal states by some studies, although the literature is not consistent, probably also due to methodological differences (e.g., Iacoviello et al., 2008; Samniah et al., 2004).”

    From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Iacoviello et al., 2008

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Research works printed but not linked: 24

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Metadata

Authors
Iacoviello, M., Guida, P., Forleo, C., Sorrentino, S., D'Alonzo, L., & Favale, S.
Affiliations
University of Bari Aldo Moro (IT)
Corresponding author
Iacoviello, M.
ORCID
Venue
Europace
Publisher
Oxford University Press (OUP)
Published
2008-10-01
Volume
10
Issue
10
Pages
1170-1175
ISSN
  • 1099-5129 (ISSN-L)
  • 1532-2092
DOI
10.1093/europace/eun217
OpenAlex
W2155188070
Cited by
30
References
2
Citations by year
2026: 2 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 2 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 1
FWCI
1.41
Type
journal article
Language
en
Open access
Locations
  • EP Europace (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
vasovagal syncope, arterial baroreflex, baroreflex sensitivity, nitroglycerin, head-up tilt, rate control, recurrent syncope, baroreflex dysfunction
MeSH terms
Adult, Blood Pressure, Female, Nitroglycerin, Humans, Male, Nitrates, Baroreflex, Tilt-Table Test, Syncope, Vasovagal

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