Dofetilide is safe and effective in preventing atrial fibrillation recurrences in patients accepted for catheter ablation
Abstract
AIMS: The aim of this study was to assess the safety and efficacy of dofetilide among patients refractory to other anti-arrhythmic drugs (AADs) and accepted for atrial fibrillation (AF) ablation. METHODS AND RESULTS: One hundred and twenty-seven of 454 patients (69% male, 58% paroxysmal, age 60 +/- 10 years, AF duration 8 +/- 7 years) scheduled for AF ablation between February 2004 and May 2008 were treated with dofetilide. Patients had failed 1.9 +/- 1.1 AADs. Anti-arrhythmic drugs were stopped five half-lives before ablation and 3 months for amiodarone. Patients were followed for 15 +/- 7 months with routine and symptom-driven monitoring. Success was defined as no further AF and partial success as a 50% reduction in frequency/duration of AF episodes. Thirty-six patients started dofetilide 158 +/- 167 days before ablation: 9 had no improvement, 16 experienced partial success, 8 had no further AF, and 2 improved enough to forgo ablation. Seventy-one patients started dofetilide immediately following ablation, of which 14 had no improvement, 22 experienced partial success, and 32 had no further AF. Twenty patients started dofetilide 119 +/- 153 days post-ablation, of which four had no improvement, seven experienced partial success, and nine had no further AF. Six patients discontinued dofetilide during initiation for QT prolongation. CONCLUSION: Dofetilide appears safe and effective in preventing AF in patients refractory to other AADs undergoing catheter ablation.
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Dofetilide occasionally restores and maintains sinus rhythm in patients refractory to other antiarrhythmic drugs.
“and occasionally in patients refractory to other antiarrhythmic drugs.667”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [667]
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
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Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
- Authors
- Shamiss, Y., Khaykin, Y., Oosthuizen, R., Tunney, D., Sarak, B., Beardsall, M., Seabrook, C., Frost, L., Wulffhart, Z., Tsang, B., & Verma, A.
- Affiliations
- Southlake Regional Health Center (CA)
- Corresponding author
- Khaykin, Yaariv
- Venue
- EP Europace
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-10-08
- Volume
- 11
- Issue
- 11
- Pages
- 1448-1455
- ISSN
- 1099-5129 (ISSN-L)
- 1532-2092
- OpenAlex
- W2065282863
- Cited by
- 17
- References
- 18
- Citations by year
- 2025: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- EP Europace (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- dofetilide, atrial fibrillation, catheter ablation, antiarrhythmic drugs, refractory atrial fibrillation, atrial fibrillation recurrence prevention, QT prolongation, drug safety, drug efficacy
- MeSH terms
- Atrial Fibrillation, Female, Humans, Male, Middle Aged, Phenethylamines, Premedication, Sulfonamides, Treatment Outcome, Catheter Ablation, Secondary Prevention
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