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Cited by 138Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Efficacy of catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy: impact of age, atrial remodelling, and disease progression

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Di Donna, P., Olivotto, I., Delcre, S. D. L., Caponi, D., Scaglione, M., Nault, I., Montefusco, A., Girolami, F., Cecchi, F., Haissaguerre, M., Gaita, F.·2010·Europace
DOI 10.1093/europace/euq013
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Abstract

AIMS: In patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF), radiofrequency catheter ablation (RFCA) represents a promising option. However, the predictors of RFCA efficacy remain largely unknown. We assessed the outcome of a multicentre HCM cohort following RFCA for symptomatic AF refractory to medical therapy. METHODS AND RESULTS: Sixty-one patients (age 54 +/- 13 years; time from AF onset 5.7 +/- 5.5 years) with paroxysmal (n = 35; 57%), recent persistent (n = 15; 25%), or long-standing persistent AF (n = 11; 18%) were enrolled. A scheme with pulmonary vein isolation plus linear lesions was employed. Of the 61 patients, 32 (52%) required redo procedures. Antiarrhythmic therapy was maintained in 22 (54%). At the end of a 29 +/- 16 months follow-up, 41 patients (67%) were in sinus rhythm, including 17 of the 19 patients aged < or = 50 years, with marked improvement in New York Heart Association (NYHA) functional class (1.2 +/- 0.5 vs. 1.9 +/- 0.7 at baseline; P < 0.001). In the remaining 20 patients (33%), with AF recurrence, there was less marked, but still significant, improvement following RFCA (NYHA class 1.8 +/- 0.7 vs. 2.3 +/- 0.7 at baseline; P = 0.002). Independent predictors of AF recurrence were increased left atrium volume [hazard ratio (HR) per unit increase 1.009, 95% confidence interval (CI) 1.001-1.018; P = 0.037] and NYHA functional class (HR 2.24, 95% CI 1.16-4.35; P = 0.016). Among 11 genotyped HCM patients (6 with MYBPC3, 2 with MYH7, 1 with MYL2 and 2 with multiple mutations), RFCA success rate was comparable with that of the overall cohort (n = 8; 73%). CONCLUSION: RFCA was successful in restoring long-term sinus rhythm and improving symptomatic status in most HCM patients with refractory AF, including the subset with proven sarcomere gene mutations, although redo procedures were often necessary. Younger HCM patients with small atrial size and mild symptoms proved to be the best RFCA candidates, likely due to lesser degrees of atrial remodelling.

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Authors
Di Donna, P., Olivotto, I., Delcre, S. D. L., Caponi, D., Scaglione, M., Nault, I., Montefusco, A., Girolami, F., Cecchi, F., Haissaguerre, M., & Gaita, F.
Affiliations
  • Azienda Ospedaliero-Universitaria Careggi (IT)
  • University of Turin (IT)
  • Hôpital Cardiologique du Haut-Lévêque (FR)
ORCID
Venue
Europace
Publisher
Oxford University Press (OUP)
Published
2010-02-20
Volume
12
Issue
3
Pages
347-355
ISSN
  • 1099-5129 (ISSN-L)
  • 1532-2092
DOI
10.1093/europace/euq013
OpenAlex
W2171261466
Cited by
138
References
28
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 8 · 2016: 14 · 2015: 8 · 2014: 18 · 2013: 10 · 2012: 12
FWCI
7.24
Type
journal article
Language
en
Open access
Locations
  • EP Europace (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders
European Commission (241577)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
hypertrophic cardiomyopathy, atrial fibrillation, radiofrequency catheter ablation, pulmonary vein isolation, atrial remodeling, left atrial volume, NYHA functional class, age, disease progression, arrhythmia recurrence, repeat ablation, genotypes, MYBPC3, MYH7, myosin light chain 2, antiarrhythmic therapy, predictors of treatment outcome, sinus rhythm
MeSH terms
Adult, Age Factors, Aged, Anti-Arrhythmia Agents, Atrial Fibrillation, Cardiomyopathy, Hypertrophic, Combined Modality Therapy, Female, Follow-Up Studies, Genetic Testing, Genotype, Heart Atria, Humans, Male, Middle Aged, Predictive Value of Tests, Echocardiography, Doppler, Treatment Outcome, Catheter Ablation, Disease Progression

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