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The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Effect of Left Ventricular Outflow Tract Obstruction on Clinical Outcome in Hypertrophic Cardiomyopathy

Maron, Martin S., Olivotto, Iacopo, Betocchi, Sandro, Casey, Susan A., Lesser, John R., Losi, Maria A., Cecchi, Franco, Maron, Barry J.·2003·New England Journal of Medicine
DOI 10.1056/nejmoa021332
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Abstract

Background The influence of left ventricular outflow tract obstruction on the clinical outcome of hypertrophic cardiomyopathy remains unresolved. Methods We assessed the effect of outflow tract obstruction on morbidity and mortality in a large cohort of patients with hypertrophic cardiomyopathy who were followed for a mean (+/-SD) of 6.3+/-6.2 years. Results Of the 1101 consecutive patients, 273 (25 percent) had obstruction of left ventricular outflow under basal (resting) conditions with a peak instantaneous gradient of at least 30 mm Hg. A total of 127 patients (12 percent) died of hypertrophic cardiomyopathy, and 216 surviving patients (20 percent) had severe, disabling symptoms of progressive heart failure (New York Heart Association [NYHA] functional class III or IV). The overall probability of death related to hypertrophic cardiomyopathy was significantly greater among patients with outflow tract obstruction than among those without obstruction (relative risk, 2.0; P=0.001). The risk of progression to NYHA class III or IV or death specifically from heart failure or stroke was also greater among patients with obstruction (relative risk, 4.4; P Conclusions In patients with hypertrophic cardiomyopathy, left ventricular outflow tract obstruction at rest is a strong, independent predictor of progression to severe symptoms of heart failure and of death.

Overview

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Registry

Crossref · 10.1056/nejmoa021332

Cites

1 of 1 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • LVOT obstruction has been identified as a predictor of sudden death in some but not all studies.

    “LVOT obstruction has been identified as a predictor of sudden death in some but not all studies”

    From Current management of hypertrophic cardiomyopathy (2025) · cites this paper as [105]

Citations

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Metadata

Authors
Maron, M. S., Olivotto, I., Betocchi, S., Casey, S. A., Lesser, J. R., Losi, M. A., Cecchi, F., & Maron, B. J.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2003-01-23
Volume
348
Issue
4
Pages
295-303
ISSN
  • 0028-4793
  • 1533-4406
DOI
10.1056/nejmoa021332
Cited by
1,259
References
1
Language
en

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