Experimental and quasi-experimental designs for evaluating guideline implementation strategies
Open accessAbstract
The choice of study design for guideline implementation studies will determine the confidence with which the observed effects can be attributed to the interventions under study. In general, cluster randomized trials, of which there are different types, provide the most robust design. However, the use of these designs has implications for the power, conduct and analysis of studies. Wherever possible, designs allowing head-to-head comparisons, which incorporate baseline measures of performance, should be used.
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Time-series designs, in which data are collected at multiple time points pre and post intervention, can increase the strength of conclusions drawn about the impact of bridge program participation.
“time-series designs, in which data are collected at multiple time points pre and post intervention in order to see the impact of the intervention beyond underlying group trends (Grimshaw et al., 2000) can increase the strength of conclusions drawn about the impact of bridge program participation.”
From A Meta-analysis of University STEM Summer Bridge Program Effectiveness (2021) · cites this paper as Grimshaw et al., 2000
Cites
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Consort 2010 statement: extension to cluster randomised trials
Campbell, M. K., Piaggio, G., Elbourne, D. R., Altman, D. G., & for the CONSORT Group (2012) · BMJ · doi:10.1136/bmj.e5661 · Cited by 3,510 · see citing works
Effectiveness and efficiency of guideline dissemination and implementation strategies
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Self-citationCONSORT statement: extension to cluster randomised trials
Campbell, M. K., Elbourne, D. R., & Altman, D. G. (2004) · BMJ · doi:10.1136/bmj.328.7441.702 · Cited by 2,557 · see citing works
The Use and Interpretation of Quasi-Experimental Studies in Medical Informatics
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Effectiveness and efficiency of guideline dissemination and implementation strategies
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Self-citationfor the MEDUSA study group, Bloos, F., Rüddel, H., Thomas-Rüddel, D., Schwarzkopf, D., Pausch, C., Harbarth, S., Schreiber, T., Gründling, M., Marshall, J., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4782-4 · Cited by 200 · see citing works
Why does primary care need more implementation research?
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Self-citationHoomans, T., Evers, S. M. A. A., Ament, A. J. H. A., Hübben, M. W. A., van der Weijden, T., Grimshaw, J. M., & Severens, J. L. (2007) · Value in Health · doi:10.1111/j.1524-4733.2007.00175.x · Cited by 71 · see citing works
Self-citationA Meta-analysis of University STEM Summer Bridge Program Effectiveness
Bradford, B. C., Beier, M. E., & Oswald, F. L. (2021) · CBE—Life Sciences Education · doi:10.1187/cbe.20-03-0046 · Cited by 73 · see citing works
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The case for randomized controlled trials to assess the impact of clinical information systems
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“Study designs include systematic reviews [13]; descriptive theory-based case studies [13-15]; ‘observational’; ‘quasi-experimental’ [11,16-18]; before-after, and, less frequently, randomized controlled trials (RCTs) [19].”
MethodUse of the bootstrap in analysing cost data from cluster randomised trials: some simulation results
Flynn, T. N., & Peters, T. J. (2004) · BMC Health Services Research · doi:10.1186/1472-6963-4-33 · Cited by 32 · see citing works
Czaja, S. J., Valente, T. W., Nair, S. N., Villamar, J. A., & Brown, C. H. (2015) · Implementation Science · doi:10.1186/s13012-016-0433-3 · Cited by 15 · see citing works
- Authors
- Grimshaw, J.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- Grimshaw, J.
- ORCID
- Grimshaw, J.
- Venue
- Family Practice
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-02-01
- Volume
- 17
- Issue
- 90001
- Pages
- 11S-16
- ISSN
- 0263-2136 (ISSN-L)
- 1460-2229
- OpenAlex
- W2102794164
- Cited by
- 382
- References
- 2
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 20 · 2023: 13 · 2022: 24 · 2021: 33 · 2020: 21 · 2019: 18 · 2018: 18 · 2017: 26 · 2016: 24 · 2015: 23 · 2014: 17 · 2013: 21 · 2012: 18
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Family Practice (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- guideline implementation, implementation strategies, research design, quasi-experimental design, head-to-head comparison, study power, evidence-based practice
- MeSH terms
- Family Practice, Health Services Research, Humans, Practice Patterns, Physicians', Randomized Controlled Trials as Topic, Practice Guidelines as Topic, Guideline Adherence
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