The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.
Faecalibacterium: a bacterial genus with promising human health applications
Open accessAbstract
In humans, many diseases are associated with alterations in gut microbiota, namely increases or decreases in the abundance of specific bacterial groups. One example is the genus Faecalibacterium. Numerous studies have underscored that low levels of Faecalibacterium are correlated with inflammatory conditions, with inflammatory bowel disease (IBD) in the forefront. Its representation is also diminished in the case of several diseases, including colorectal cancer (CRC), dermatitis, and depression. Additionally, the relative presence of this genus is considered to reflect, at least in part, intestinal health status because Faecalibacterium is frequently present at reduced levels in individuals with gastrointestinal diseases or disorders. In this review, we first thoroughly describe updates to the taxonomy of Faecalibacterium, which has transformed a single-species taxon to a multispecies taxon over the last decade. We then explore the links discovered between Faecalibacterium abundance and various diseases since the first IBD-focused studies were published. Next, we examine current available strategies for modulating Faecalibacterium levels in the gut. Finally, we summarize the mechanisms underlying the beneficial effects that have been attributed to this genus. Together, epidemiological and experimental data strongly support the use of Faecalibacterium as a next-generation probiotic (NGP) or live biotherapeutic product (LBP).
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Cites
1 retracted
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“…abunance to neurological conditions is far more preliminary than that xamining the links with diseases such as IBD. ancer he gut microbiota also appears to have an impact on the efficacy f imm une c hec kpoint inhibitors (Routy et al. 2018 , Daillere et al. 020 , Effendi et al. 2022 ).”
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Self-citation
Cited by
Gut microbiota variations in depression and anxiety: a systematic review
Cao, Y., Cheng, Y., Pan, W., Diao, J., Sun, L., & Meng, M. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06871-8 · Cited by 80
Gut dysbiosis in oncology: a risk factor for immunoresistance
(2026) · doi:10.1038/s41422-025-01212-6 · Cited by 24
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CauTrigger: deciphering biological system state transitions by hierarchical causal decomposition
Zhang, C., Cai, D., Aihara, K., & Chen, L. (2026) · Nature Methods · doi:10.1038/s41592-026-03274-9
Metadata
- Authors
- Martín, R., Rios-Covian, D., Huillet, E., Auger, S., Khazaal, S., Bermúdez-Humarán, L. G., Sokol, H., Chatel, J.-M., & Langella, P.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2023-07
- Volume
- 47
- Issue
- 4
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W4384276655
- Cited by
- 566
- References
- 202
- FWCI
- 42.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Martín, R., Rios-Covian, D., Huillet, E., Auger, S., Khazaal, S., Bermúdez-Humarán, L. G., Sokol, H., Chatel, J.-M., & Langella, P. (2023). Faecalibacterium: a bacterial genus with promising human health applications. FEMS Microbiology Reviews. https://doi.org/10.1093/femsre/fuad039
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