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Cited by 4Fungal and yeast genetics researchFermentation and Sensory AnalysisMicrobial Metabolic Engineering and Bioproduction

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Genome-wide transcriptional regulation in Saccharomyces cerevisiae in response to carbon dioxide

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Tan, Lin-Rui, Liu, Jing-Jing, Deewan, Anshu, Lee, Jae Won, Xia, Peng-Fei, Rao, Christopher V, Jin, Yong-Su, Wang, Shu-Guang·2022·FEMS Yeast Research
DOI 10.1093/femsyr/foac032
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Abstract

Sugar metabolism by Saccharomyces cerevisiae produces ample amounts of CO2 under both aerobic and anaerobic conditions. High solubility of CO2 in fermentation media, contributing to enjoyable sensory properties of sparkling wine and beers by S. cerevisiae, might affect yeast metabolism. To elucidate the overlooked effects of CO2 on yeast metabolism, we examined glucose fermentation by S. cerevisiae under CO2 as compared to N2 and O2 limited conditions. While both CO2 and N2 conditions are considered anaerobic, less glycerol and acetate but more ethanol were produced under CO2 condition. Transcriptomic analysis revealed that significantly decreased mRNA levels of GPP1 coding for glycerol-3-phosphate phosphatase in glycerol synthesis explained the reduced glycerol production under CO2 condition. Besides, transcriptional regulations in signal transduction, carbohydrate synthesis, heme synthesis, membrane and cell wall metabolism, and respiration were detected in response to CO2. Interestingly, signal transduction was uniquely regulated under CO2 condition, where upregulated genes (STE3, MSB2, WSC3, STE12, and TEC1) in the signal sensors and transcriptional factors suggested that MAPK signaling pathway plays a critical role in CO2 sensing and CO2-induced metabolisms in yeast. Our study identifies CO2 as an external stimulus for modulating metabolic activities in yeast and a transcriptional effector for diverse applications.

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Metadata

Authors
Tan, L.-R., Liu, J.-J., Deewan, A., Lee, J. W., Xia, P.-F., Rao, C. V., Jin, Y.-S., & Wang, S.-G.
Affiliations
  • Shandong University (CN)
  • Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign , Urbana, IL 61801, United States
  • University of Illinois Urbana-Champaign (US)
  • School of Environmental Science and Engineering, Shandong University , Qingdao 266237, P. R. China
Corresponding author
Jin, Yong-Su
ORCID
Venue
FEMS Yeast Research
Publisher
Oxford University Press (OUP)
Published
2022
Volume
22
Issue
1
ISSN
  • 1567-1356 (ISSN-L)
  • 1567-1364
DOI
10.1093/femsyr/foac032
OpenAlex
W4282934679
Cited by
4
References
4
Citations by year
2025: 2 · 2024: 1 · 2023: 1
FWCI
0.33
Type
journal article
Language
en
Open access
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • FEMS Yeast Research (publishedVersion)
  • PubMed (publishedVersion)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders
  • U.S. Department of Energy (DESC0018420)
  • Office of Science (DESC0018420)
  • Biological and Environmental Research (DE‐SC0018420)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Fermentation and Sensory Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords
Saccharomyces cerevisiae, carbon dioxide, glucose fermentation, transcriptional regulation, glycerol production, MAPK signaling, signal transduction, ethanol production, acetate production, carbon dioxide detection, yeast metabolism
MeSH terms
Carbon Dioxide, Fermentation, Glycerol, Membrane Proteins, Saccharomyces cerevisiae, Wine, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins

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