Editorial: Yeast synthetic biology: new tools to unlock cellular function
Open accessAbstract
Yeasts play a central role in industrial biotechnology and basic genetic research. Recently, we have seen an expansion of their traditional role in food and wine making to one of industrial chemical and protein production. This transition is, in part, enabled by a convergence of new capacities that have shaped the ability to rewire this organism. Namely, the past decade has seen genome sequence availability, cheap DNA synthesis, rapid assembly technologies and newfound capacity to understand synthetic parts and build these parts into complex pathways and circuits. Collectively, these capabilities …
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A fully rational approach to designing functional 5′ UTRs has not yet been implemented.
“While there has been some success in this effort in prokaryotes, yeast and even mammalian cells27,34–36, a fully rational approach to designing functional 5′ UTRs has not yet been implemented.”
From Human 5′ UTR design and variant effect prediction from a massively parallel translation assay (2019) · cites this paper as [35]
The editorial’s section “Yeast synthetic biology: new tools to unlock cellular function” discusses advances in synthetic-part design, but does not address 5′ UTRs or whether a fully rational approach to designing them has been implemented. Searches for 5′ UTR design and the claimed limitation found no passage that settles it; the copy has no page numbers. (LLM, conf=0.75)
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Human 5′ UTR design and variant effect prediction from a massively parallel translation assay
Sample, P. J., Wang, B., Reid, D. W., Presnyak, V., McFadyen, I. J., Morris, D. R., & Seelig, G. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0164-5 · Cited by 442 · see citing works
Bricks and blueprints: methods and standards for DNA assembly.
Casini, A., Storch, M., Baldwin, G. S., & Ellis, T. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4014 · Cited by 286 · see citing works
Recent advances in synthetic biology of cyanobacteria for improved chemicals production
Wang, F., Gao, Y., & Yang, G. (2020) · Bioengineered · doi:10.1080/21655979.2020.1837458 · Cited by 49 · see citing works
- Authors
- Alper, H. S., Kang, H. A., & Siewers, V.
- Affiliations
- The University of Texas at Austin (US)
- Chung-Ang University (KR)
- Chalmers University of Technology (SE)
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-01-16
- Volume
- 15
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1567-1356 (ISSN-L)
- 1567-1364
- OpenAlex
- W2065997128
- Cited by
- 164
- References
- 0
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 5 · 2023: 3 · 2022: 14 · 2021: 14 · 2020: 19 · 2019: 26 · 2018: 20 · 2017: 23 · 2016: 15 · 2015: 10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Yeast Research (publishedVersion)
- PubMed (publishedVersion)
- Chalmers Research (Chalmers University of Technology) (submittedVersion)
- Chalmers Publication Library (Chalmers University of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- industrial biotechnology, synthetic gene circuits, DNA synthesis, genome assembly, metabolic pathway engineering, protein production, industrial chemical production
- MeSH terms
- Humans, Industrial Microbiology, Saccharomyces cerevisiae, Genome, Fungal, Synthetic Biology, Metabolic Engineering
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