SEGREGATION ANALYSES AND GENE-CENTROMERE DISTANCES IN ZEBRAFISH
Abstract
The gol-1, gol-2, alb-1 and spa-1 mutations affect pigment pattern in the zebrafish. We show here that these loci are unlinked to each other. In addition, gene-centromere distances were determined for these loci by analysis of halftetrads obtained by the inhibition of the second meiotic division. The fractions of tetratype (second-division segregation) tetrads range from 0.24 (spa-1) to 0.89 (gol-1). The observation of >0.67 second-division segregation indicates that the zebrafish has high chiasma interference.
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The albino (albb4/b4) mutant is characterised by a general deficiency in melanin production due to a mutation in the slc45a2 gene.
“The albino (albb4/b4) mutant is characterised by a general deficiency in the production of melanin due to a mutation in the slc45a2 gene18.”
From A crystal-clear zebrafish for in vivo imaging (2016) · cites this paper as [18]
The Results section identifies alb-1 as a zebrafish pigment-pattern mutation and says it affects the appearance of other pigment mutants. Our copy does not identify the alb b4 allele, establish a general deficiency in melanin production, or link the mutation to slc45a2 (searched: alb-1(b4), melanin, slc45a2). (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe combinatorial crystal mutant (albb4/b4;nacrew2/w2;roya9/a9) was generated by sequentially crossbreeding three single mutant strains: nacrew2/w2, roya9/a9 and albb4/b4.
“The combinatorial crystal mutant (albb4/b4;nacrew2/w2;roya9/a9) was generated by sequentially crossbreeding three different single mutant strains, namely nacrew2/w2 (ref. 9), roya9/a9 (ref. 4) and albb4/b4 (ref. 18) mutants.”
From A crystal-clear zebrafish for in vivo imaging (2016) · cites this paper as [18]
The Results describe alb-1 as a recessive zebrafish pigment-pattern mutant, supporting the citation’s identification of an alb mutant strain. Our copy does not establish the specific b4/b4 allele or describe the sequential crosses used to generate the combinatorial crystal mutant. (LLM, conf=0.78)
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Cited by
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Thisse, C., Thisse, B., Schilling, T. F., & Postlethwait, J. H. (1993) · Development · doi:10.1242/dev.119.4.1203 · Cited by 877 · see citing works
Halpern, M. E., Thisse, C., Ho, R. K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E. S., Postlethwait, J. H., & Kimmel, C. B. (1995) · Development · doi:10.1242/dev.121.12.4257 · Cited by 178 · see citing works
A crystal-clear zebrafish for in vivo imaging
Antinucci, P., & Hindges, R. (2016) · Scientific Reports · doi:10.1038/srep29490 · Cited by 165 · see citing works
Axial Mesoderm and Patterning of the Zebrafish Embryo
HALPERN, M. E. (1997) · American Zoologist · doi:10.1093/icb/37.3.311 · Cited by 15 · see citing works
- Authors
- Streisinger, G., Singer, F., Walker, C., Knauber, D., & Dower, N.
- Affiliations
- University of Oregon (US)
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-02-01
- Volume
- 112
- Issue
- 2
- Pages
- 311-319
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2121859376
- Cited by
- 245
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 5 · 2016: 10 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM 22731)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- zebrafish, pigmentation patterns, chiasma interference, meiotic recombination, linkage analysis
- MeSH terms
- Animals, Centromere, Chromosomes, Fishes, Genetic Markers, Homozygote, Genetic Linkage, Lod Score, Mutation, Pigmentation, Recombination, Genetic
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