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The coalescent process in models with selection and recombination.
Open accessAbstract
The statistical properties of the process describing the genealogical history of a random sample of genes at a selectively neutral locus which is linked to a locus at which natural selection operates are investigated. It is found that the equations describing this process are simple modifications of the equations describing the process assuming that the two loci are completely linked. Thus, the statistical properties of the genealogical process for a random sample at a neutral locus linked to a locus with selection follow from the results obtained for the selected locus. Sequence data from the alcohol dehydrogenase (Adh) region of Drosophila melanogaster are examined and compared to predictions based on the theory. It is found that the spatial distribution of nucleotide differences between Fast and Slow alleles of Adh is very similar to the spatial distribution predicted if balancing selection operates to maintain the allozyme variation at the Adh locus. The spatial distribution of nucleotide differences between different Slow alleles of Adh do not match the predictions of this simple model very well.
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Citations
Cited by
The “hitchhiking effect” revisited
Kaplan, N. L., Hudson, R. R., & Langley, C. H. (1989) · Genetics · doi:10.1093/genetics/123.4.887 · Cited by 1,076
Self-citationPhylogenetic Incongruence: Window into Genome History and Molecular Evolution
Wendel, J. F., & Doyle, J. J. (1998) · Molecular Systematics of Plants II · doi:10.1007/978-1-4615-5419-6_10 · Cited by 649
Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis
Stahl, E. A., Dwyer, G., Mauricio, R., Kreitman, M., & Bergelson, J. (1999) · Nature · doi:10.1038/23260 · Cited by 600
Ancestral Inference from Samples of DNA Sequences with Recombination
GRIFFITHS, R. C., & MARJORAM, P. (1996) · Journal of Computational Biology · doi:10.1089/cmb.1996.3.479 · Cited by 403
Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees
Leffler, E. M., Gao, Z., Pfeifer, S., Ségurel, L., Auton, A., Venn, O., Bowden, R., Bontrop, R., Wall, J. D., Sella, G., et al. (2013) · Science · doi:10.1126/science.1234070 · Cited by 326
Metadata
- Authors
- Hudson, R. R., & Kaplan, N. L.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-11-01
- Volume
- 120
- Issue
- 3
- Pages
- 831-840
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2157394513
- Cited by
- 428
- References
- 0
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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