Host movement and the genetic structure of populations of parasitic nematodes.

Blouin, M S; Yowell, C A; Courtney, C H; Dame, J B

doi:10.1093/genetics/141.3.1007

Cited by 387Helminth infection and controlParasite Biology and Host InteractionsGenetic diversity and population structure

Host movement and the genetic structure of populations of parasitic nematodes.

Blouin, M S, Yowell, C A, Courtney, C H, Dame, J B·1995·Genetics

DOI 10.1093/genetics/141.3.1007

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Abstract

Mitochondrial DNA (mtDNA) sequence data were used to compare the population genetic structures of five species of parasitic nematodes from three different hosts: Ostertagia ostertagi and Haemonchus placei from cattle, H. contortus and Teladorsagia circumcincta from sheep, and Mazamastrongylus odocoilei from white-tailed deer. The parasites of sheep and cattle showed a pattern consistent with high gene flow among populations. The parasite of deer showed a pattern of substantial population subdivision and isolation by distance. It appears that host movement is an important determinant of population genetic structure in these nematodes. High gene flow in the parasites of livestock also indicates great opportunity for the spread of rare alleles that confer resistance to anthelmintic drugs. All species, including the parasite of deer, had unusually high within-population diversities (averages of 0.019-0.027 substitutions per site between pairs of individuals from the same population). Large effective population sizes (Ne), perhaps in combination with rapid mtDNA evolution, appear to be the most likely explanation for these high within-population diversities.

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Parasitic strongylid nematodes have genetic features that favour development of anthelmintic resistance, including rapid nucleotide sequence evolution and large effective population sizes leading to high genetic diversity.
“Parasitic strongylid nematodes have a number of genetic features, which favour the development of anthelmintic resistance, such as rapid rates of nucleotide sequence evolution and exceedingly large effective population sizes, leading to remarkably high levels of genetic diversity [21, 22].”
From Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat? (2019) · cites this paper as [21]
The Discussion (p. 7) proposes large effective population size, perhaps combined with accelerated nucleotide substitution, as an explanation for the high diversity observed in trichostrongylids. It treats faster nucleotide evolution as a hypothesis, not an established feature. Its discussion of anthelmintic resistance (p. 7) links its spread to high gene flow, rather than showing that the proposed diversity mechanisms favour resistance development. (LLM, conf=0.86)
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Authors: Blouin, M. S., Yowell, C. A., Courtney, C. H., & Dame, J. B.
Affiliations: University of Florida (US)
Oregon State University (US)
ORCID: Blouin, M S
Yowell, C A
Dame, J B
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1995-11-01
Volume: 141
Issue: 3
Pages: 1007-1014
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/141.3.1007
OpenAlex: W2096870868
Cited by: 387
References: 30
Citations by year: 2026: 12 · 2025: 14 · 2024: 11 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 11 · 2018: 15 · 2017: 15 · 2016: 23 · 2015: 19 · 2014: 17 · 2013: 21 · 2012: 15
FWCI: 7.51
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Veterinary › Small Animals › Helminth infection and control
Physical Sciences › Environmental Science › Ecology › Parasite Biology and Host Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords: host movement, population structure, parasitic nematodes, mitochondrial DNA, gene flow, isolation by distance, population subdivision, Ostertagia ostertagi, Haemonchus contortus, Haemonchus placei, Teladorsagia circumcincta, anthelmintic resistance, effective population size, livestock parasites, deer parasites
MeSH terms: Alleles, Animals, Anthelmintics, Base Sequence, Cattle, Cattle Diseases, Deer, Demography, DNA, Mitochondrial, Drug Resistance, Gene Frequency, Genetics, Population, Haemonchiasis, Haemonchus, Host-Parasite Interactions, Molecular Sequence Data, Ostertagia, Ostertagiasis, Population Density, Sheep, Sheep Diseases, Trichostrongyloidea, Trichostrongyloidiasis, United States, Genetic Variation, Sequence Alignment, Evolution, Molecular

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Host movement and the genetic structure of populations of parasitic nematodes.

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