The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Estimating Recombination Rates From Population Genetic Data
Open accessAbstract
We introduce a new method for estimating recombination rates from population genetic data. The method uses a computationally intensive statistical procedure (importance sampling) to calculate the likelihood under a coalescent-based model. Detailed comparisons of the new algorithm with two existing methods (the importance sampling method of Griffiths and Marjoram and the MCMC method of Kuhner and colleagues) show it to be substantially more efficient. (The improvement over the existing importance sampling scheme is typically by four orders of magnitude.) The existing approaches not infrequently led to misleading results on the problems we investigated. We also performed a simulation study to look at the properties of the maximum-likelihood estimator of the recombination rate and its robustness to misspecification of the demographic model.
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Cites
Hudson, R. R., & Kaplan, N. L. (1985) · Genetics · doi:10.1093/genetics/111.1.147 · Cited by 1,555
Prospects for whole-genome linkage disequilibrium mapping of common disease genes
Kruglyak, L. (1999) · Nature Genetics · doi:10.1038/9642 · Cited by 1,416
Cited by
The International HapMap Project
†The International HapMap Consortium, Genotyping centres: Baylor College of Medicine and ParAllele BioScience, Gibbs, R. A., Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Chinese HapMap Consortium, Yang, H., Ch'ang, L.-Y., et al. (2003) · Nature · doi:10.1038/nature02168 · Cited by 6,057
Self-citationDrummond, A. J., Nicholls, G. K., Rodrigo, A. G., & Solomon, W. (2002) · Genetics · doi:10.1093/genetics/161.3.1307 · Cited by 1,059
A Coalescent-Based Method for Detecting and Estimating Recombination From Gene Sequences
McVean, G., Awadalla, P., & Fearnhead, P. (2002) · Genetics · doi:10.1093/genetics/160.3.1231 · Cited by 708
Self-citationHaplotype blocks and linkage disequilibrium in the human genome
Wall, J. D., & Pritchard, J. K. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1123 · Cited by 642
Genome-Wide Inference of Ancestral Recombination Graphs
Rasmussen, M. D., Hubisz, M. J., Gronau, I., & Siepel, A. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004342 · Cited by 371
Metadata
- Authors
- Fearnhead, P., & Donnelly, P.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-11-01
- Volume
- 159
- Issue
- 3
- Pages
- 1299-1318
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2165601275
- Cited by
- 314
- References
- 2
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fearnhead, P., & Donnelly, P. (2001). Estimating Recombination Rates From Population Genetic Data. Genetics. https://doi.org/10.1093/genetics/159.3.1299
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
