The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Positive Selection of Caenorhabditis elegans Mutants With Increased Stress Resistance and Longevity
Abstract
We developed selective conditions for long-lived mutants of the nematode Caenorhabditis elegans by subjecting the first larval stage (L1) to thermal stress at 30° for 7 days. The surviving larvae developed to fertile adults after the temperature was shifted to 15°. A total of one million F2 progeny and a half million F3 progeny of ethyl-methanesulfonate-mutagenized animals were treated in three separate experiments. Among the 81 putative mutants that recovered and matured to the reproductive adult, 63 retested as thermotolerant and 49 (80%) exhibited a >15% increase in mean life span. All the known classes of dauer formation (Daf) mutant that affect longevity were found, including six new alleles of daf-2, and a unique temperature-sensitive, dauer-constitutive allele of age-1. Alleles of dyf-2 and unc-13 were isolated, and mutants of unc-18, a gene that interacts with unc-13, were also found to be long lived. Thirteen additional mutations define at least four new genes.
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Cites
The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573
The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions
Avery, L., Bargmann, C. I., & Horvitz, H. R. (1993) · Genetics · doi:10.1093/genetics/134.2.455 · Cited by 137
Neurosecretory control of aging in Caenorhabditis elegans
Ailion, M., Inoue, T., Weaver, C. I., Holdcraft, R. W., & Thomas, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7394 · Cited by 121
Cited by
Aging as an event of proteostasis collapse
Taylor, R. C., & Dillin, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004440 · Cited by 538
Insulin/insulin-like growth factor signaling in C. elegans
Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 532
The C. elegans TGF-β Dauer Pathway Regulates Longevity via Insulin Signaling
Shaw, W. M., Luo, S., Landis, J., Ashraf, J., & Murphy, C. T. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.058 · Cited by 260
Cai, T., Fukushige, T., Notkins, A. L., & Krause, M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0101-04.2004 · Cited by 63
Trait drift in microalgae and applications for strain improvement
Jebali, A., Sanchez, M. R., Hanschen, E. R., Starkenburg, S. R., & Corcoran, A. A. (2022) · Biotechnology Advances · doi:10.1016/j.biotechadv.2022.108034 · Cited by 30
Metadata
- Authors
- Muñoz, M. J., & Riddle, D. L.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01-01
- Volume
- 163
- Issue
- 1
- Pages
- 171-180
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2158538546
- Cited by
- 168
- References
- 4
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
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