SYNTHETIC LETHALITY AND SEMI-LETHALITY AMONG FUNCTIONALLY RELATED MUTANTS OF DROSOPHILA MELANOGASTER

Lucchesi, John C

doi:10.1093/genetics/59.1.37

Cited by 141Neurobiology and Insect Physiology ResearchDevelopmental Biology and Gene RegulationBiochemical and Molecular Research

SYNTHETIC LETHALITY AND SEMI-LETHALITY AMONG FUNCTIONALLY RELATED MUTANTS OF DROSOPHILA MELANOGASTER

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Lucchesi, John C·1968·Genetics

DOI 10.1093/genetics/59.1.37

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Abstract

sex-linked mutant deep orange (dor) of Drosophila melanogaster is Tzonsible for a peculiar type of female sterility: mutant females produce no progeny when crossed to mutant males but yield some offspring (heterozygous daughters) when mated to wild-type males (MERRELL 1947). The effects of this mutant on embryonic development have been extensively studied by COUNCE (1956a) and more recently by HILDRETH and LUCCHESI (1967). In addition to the sterility phene, dor alters the pigmentation of the eyes (which are orange in color) and confers an abnormal spectrum of relative pteridine concentrations. An unusual characteristic of dor is that isoxanthopterin appears to be accumulated by mutant females (COUNCE 1957). During the course of preliminary investigations into the biochemical basis of dor female-sterility, art attempt was made to prevent the accumulation of isoxanthopterin in mutant females by genetic means. This resulted in the discovery of a highly specific synthetic lethal system involving dor and a non-allelic third chromosome mutant, rosy (ry) . The dor-ry system is similar to three other synthetic lethal systems, previously described in D. melanogaster: purpleoid (pd) and Purpleoider (Pdr) (BRIDGES 1922; as cited in BRIDGES and BREHME 1944) ; prune (pn) and Prune-killer (K-pn) ( STURTEVANT 1956) ; and Henna-recessiue-3 (Hnr3) and rosy (ry6) (TAIRA 1960; GOLDBERG, SCHALET and CHOVNICK 1962). A search was undertaken for the purpose of uncovering additional interactions among some of the mutants mentioned above. Since six of the latter affect eye color and/or pteridine levels, a number of other eye color mutants were tested. In addition, the female sterile mutant fused (fu) , similar in many respects to dor (although allowing lethal embryos to develop further than dor embryos (COUNCE 195613) ). was used in <some crosses. The results of these investigations are presented in this paper.

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Synthetic genetic interaction screens in yeast show thousands of combinations of individually viable mutations can be jointly lethal, with similar examples in Drosophila and C. elegans.
“Synthetic genetic interaction screens in yeast123,124 have demonstrated that thousands of combinations of individually viable mutations can jointly be lethal, and similar examples have been documented in Drosophila melanogaster and Caenorhabditis elegans125,126.”
From Rare and common variants: twenty arguments (2012) · cites this paper as [125]

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Authors: Lucchesi, J. C.
Corresponding author: Lucchesi, John C
ORCID: Lucchesi, John C
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1968-05-01
Volume: 59
Issue: 1
Pages: 37-44
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/59.1.37
OpenAlex: W2123596976
Cited by: 139
References: 5
Citations by year: 2026: 5 · 2025: 11 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 4
FWCI: 0.74
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: synthetic lethality, female sterility, isoxanthopterin, pteridines, eye color mutants, Drosophila melanogaster, third chromosome
MeSH terms: Crosses, Genetic, Drosophila, Female, Genes, Lethal, Infertility, Female, Male, Mutation, Pigmentation, Pteridines

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SYNTHETIC LETHALITY AND SEMI-LETHALITY AMONG FUNCTIONALLY RELATED MUTANTS OF DROSOPHILA MELANOGASTER

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