LINKAGE DISEQUILIBRIUM AT STEADY STATE DETERMINED BY RANDOM GENETIC DRIFT AND RECURRENT MUTATION

Ohta, Tomoko; Kimura, Motoo

doi:10.1093/genetics/63.1.229

Cited by 181Evolution and Genetic DynamicsGenetic diversity and population structureGenetic Associations and Epidemiology

LINKAGE DISEQUILIBRIUM AT STEADY STATE DETERMINED BY RANDOM GENETIC DRIFT AND RECURRENT MUTATION

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Ohta, Tomoko, Kimura, Motoo·1969·Genetics

DOI 10.1093/genetics/63.1.229

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Tomoko Ohta, Motoo Kimura; LINKAGE DISEQUILIBRIUM AT STEADY STATE DETERMINED BY RANDOM GENETIC DRIFT AND RECURRENT MUTATION, Genetics, Volume 63, Issue 1,

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Genetic drift balanced by mutation and recombination would maintain only low levels of LD, and the expectation of D2 is small even without recombination.
“Results first obtained in the late 1960s suggested that genetic drift balanced by mutation and recombination would maintain only low levels of LD, and the expectation of D2 is small even if there is no recombination53,54 because the flux of mutations at both loci tends to eliminate most LD.”
From Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. (2008) · cites this paper as [54]
The introduction describes a steady state in which drift and recurrent mutation balance, and the Discussion gives an example where linkage disequilibrium between neighboring loci may be unimportant. But the paper also says disequilibrium becomes more important when recombination is very low; it does not establish that E(D²) remains small without recombination or that mutation eliminates most LD in that case. The indexed passages have no page numbers. (LLM, conf=0.83)
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ATTAINMENT OF QUASI LINKAGE EQUILIBRIUM WHEN GENE FREQUENCIES ARE CHANGING BY NATURAL SELECTION
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THE NUMBER OF HETEROZYGOUS NUCLEOTIDE SITES MAINTAINED IN A FINITE POPULATION DUE TO STEADY FLUX OF MUTATIONS
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Authors: Ohta, T., & Kimura, M.
Affiliations: National Institute of Genetics (JP)
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1969-09-01
Volume: 63
Issue: 1
Pages: 229-238
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/63.1.229
OpenAlex: W2105409312
Cited by: 181
References: 3
Citations by year: 2026: 1 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 2 · 2012: 6
FWCI: 5.54
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: linkage disequilibrium, steady state, genetic drift, recurrent mutations, mutation-selection balance, population genetics
MeSH terms: Alleles, Gene Frequency, Genes, Genes, Dominant, Genetics, Population, Models, Theoretical, Mutation, Recombination, Genetic

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LINKAGE DISEQUILIBRIUM AT STEADY STATE DETERMINED BY RANDOM GENETIC DRIFT AND RECURRENT MUTATION

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