The DOI matches its Crossref record.
DISTRIBUTION OF GENE FREQUENCY AS A TEST OF THE THEORY OF THE SELECTIVE NEUTRALITY OF POLYMORPHISMS
Open accessAbstract
The variation in gene frequency among populations or between generations within a population is a result of breeding structure and selection. But breeding structure should affect all loci and alleles in the same way. If there is significant heterogeneity between loci in their apparent inbreeding coefficients F=sp2/p(1-p), this heterogeneity may be taken as evidence for selection. We have given the statistical properties of F and shown how tests of heterogeneity can be made. Using data from human populations we have shown highly significant heterogeneity in F values for human polymorphic genes over the world, thus demonstrating that a significant fraction of human polymorphisms owe their current gene frequencies to the action of natural selection. We have also applied the method to temporal variation within a population for data on Dacus oleae and have found no significant evidence of selection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162
Molecular Signatures of Natural Selection
Nielsen, R. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.112420 · Cited by 1,641
Evaluating loci for use in the genetic analysis of population structure.
(1996) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.1996.0237 · Cited by 1,535
Positive Natural Selection in the Human Lineage
Sabeti, P. C., Schaffner, S. F., Fry, B., Lohmueller, J., Varilly, P., Shamovsky, O., Palma, A., Mikkelsen, T. S., Altshuler, D., & Lander, E. S. (2006) · Science · doi:10.1126/science.1124309 · Cited by 1,157
Interrogating a High-Density SNP Map for Signatures of Natural Selection
Akey, J. M., Zhang, G., Zhang, K., Jin, L., & Shriver, M. D. (2002) · Genome Research · doi:10.1101/gr.631202 · Cited by 964
Metadata
- Authors
- Lewontin, R. C., & Krakauer, J.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-05-01
- Volume
- 74
- Issue
- 1
- Pages
- 175-195
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2103286878
- Cited by
- 1,181
- References
- 0
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: DISTRIBUTION OF GENE FREQUENCY AS A TEST OF THE THEORY OF THE SELECTIVE NEUTRALITY OF POLYMORPHISMS. https://app.cochat.ai/papers/10.1093/genetics/74.1.175
- The paper
- Lewontin, R. C., & Krakauer, J. (1973). DISTRIBUTION OF GENE FREQUENCY AS A TEST OF THE THEORY OF THE SELECTIVE NEUTRALITY OF POLYMORPHISMS. Genetics. https://doi.org/10.1093/genetics/74.1.175
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
