Cited by 241Evolution and Genetic DynamicsGenetic diversity and population structureStochastic processes and statistical mechanics

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

THE AGE OF A NEUTRAL MUTANT PERSISTING IN A FINITE POPULATION

Open access

Kimura, Motoo, Ohta, Tomoko·1973·Genetics

DOI 10.1093/genetics/75.1.199

Open this paper in CoChat — free account

Abstract

Formulae for the mean and the mean square age of a neutral allele which is segregating with frequency x in a population of effective size Ne have been obtained using the diffusion equation method, for the case of 4Nev<1 where v is the mutation rate. It has been shown that the average ages of neutral alleles, even if their frequencies are relatively low, are quite old. For example, a neutral mutant whose current frequency is 10% has the expected age roughly equal to the effective population size Ne and the standard deviation 1.4Ne (in generations), assuming that this mutant has increased by random drift from a very low frequency. Also, formulae for the mean "first arrival time" of a neutral mutant to a certain frequency x have been presented. In addition, a new, approximate method has been developed which enables us to obtain the condition under which frequencies of "rare" polymorphic alleles among local populations are expected to be uniform if the alleles are selectively neutral.—It was concluded that exchange of only a few individuals on the average between adjacent colonies per generation is enough to bring about such a uniformity of frequencies.

Integrity signals

Registry

Crossref · 10.1093/genetics/75.1.199

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION
Kimura, M., & Crow, J. F. (1964) · Genetics · doi:10.1093/genetics/49.4.725 · Cited by 2,621
Self-citation
Diffusion models in population genetics
Kimura, M. (1964) · Journal of Applied Probability · doi:10.2307/3211856 · Cited by 773
Self-citation
SELECTION FOR HETEROZYGOTES IN SMALL POPULATIONS
Robertson, A. (1962) · Genetics · doi:10.1093/genetics/47.9.1291 · Cited by 258
Pattern of neutral polymorphism in a geographically structured population
Kimura, M., & Maruyama, T. (1971) · Genetics Research · doi:10.1017/s0016672300012520 · Cited by 183
Self-citation
Development of associative overdominance through linkage disequilibrium in finite populations
Ohta, T., & Kimura, M. (1970) · Genetics Research · doi:10.1017/s0016672300002391 · Cited by 111
Self-citation

Show all 5 references

Sorted by citations

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843
Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
Li, J. Z., Absher, D. M., Tang, H., Southwick, A. M., Casto, A. M., Ramachandran, S., Cann, H. M., Barsh, G. S., Feldman, M. W., Cavalli-Sforza, L. L., et al. (2008) · Science · doi:10.1126/science.1153717 · Cited by 1,915
Genetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
Fu, W., O’Connor, T. D., Jun, G., Kang, H. M., Abecasis, G. R., Leal, S. M., Gabriel, S., Rieder, M. J., Altshuler, D., Shendure, J., et al. (2012) · Nature · doi:10.1038/nature11690 · Cited by 969
Line-of-descent and genealogical processes, and their applications in population genetics models
Tavaré, S. (1984) · Theoretical Population Biology · doi:10.1016/0040-5809(84)90027-3 · Cited by 581
Dating the Origin of the CCR5-Δ32 AIDS-Resistance Allele by the Coalescence of Haplotypes
Stephens, J. C., Reich, D. E., Goldstein, D. B., Shin, H. D., Smith, M. W., Carrington, M., Winkler, C., Huttley, G. A., Allikmets, R., Schriml, L., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301867 · Cited by 520
Evidence of positive selection acting at the human dopamine receptor D4 gene locus
Ding, Y. C., Chi, H. C., Grady, D., Morishima, A., Kidd, J., Kidd, K., Flodman, P., Spence, M., Schuck, S., Swanson, J., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.012464099 · Cited by 506
Minor allele frequency thresholds strongly affect population structure inference with genomic data sets
Linck, E. B., & Battey, C. J. (2019) · Molecular Ecology Resources · doi:10.1111/1755-0998.12995 · Cited by 402
Ancestral Inference in Population Genetics
Griffiths, R., & Tavaré, S. (1994) · Statistical Science · doi:10.1214/ss/1177010378 · Cited by 385
Probability Models for DNA Sequence Evolution
Durrett, R. (2002) · Probability and its applications · doi:10.1007/978-1-4757-6285-3 · Cited by 366
Inferring whole-genome histories in large population datasets
Kelleher, J., Wong, Y., Wohns, A. W., Fadil, C., Albers, P. K., & McVean, G. (2019) · Nature Genetics · doi:10.1038/s41588-019-0483-y · Cited by 313
Extent and Distribution of Linkage Disequilibrium in Three Genomic Regions
Abecasis, G. R., Noguchi, E., Heinzmann, A., Traherne, J. A., Bhattacharyya, S., Leaves, N. I., Anderson, G. G., Zhang, Y., Lench, N., Carey, A. H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/316944 · Cited by 328
Recombination initiation maps of individual human genomes
Pratto, F., Brick, K., Khil, P., Smagulova, F., Petukhova, G. V., & Camerini-Otero, R. D. (2014) · Science · doi:10.1126/science.1256442 · Cited by 295
THE USE OF RESTRICTION ENDONUCLEASES TO MEASURE MITOCHONDRIAL DNA SEQUENCE RELATEDNESS IN NATURAL POPULATIONS. I. POPULATION STRUCTURE AND EVOLUTION IN THE GENUS PEROMYSCUS
Avise, J. C., Lansman, R. A., & Shade, R. O. (1979) · Genetics · doi:10.1093/genetics/92.1.279 · Cited by 281
Why Do Some Tropical Forests Have So Many Species of Trees?
Leigh, E. G., Davidar, P., Dick, C. W., John, T., Puyravaud, J., ter Steege, H., & Wright, S. J. (2004) · Biotropica · doi:10.1646/1607 · Cited by 294
Mapping of mitochondrial DNA of individual sheep and goats: Rapid evolution in the D loop region
Upholt, W. B., & Dawid, I. B. (1977) · Cell · doi:10.1016/0092-8674(77)90075-7 · Cited by 247
Gene Losses during Human Origins
Wang, X., Grus, W. E., & Zhang, J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040052 · Cited by 246
The age of a mutation in a general coalescent tree
Griffiths, R., & Tavaré, S. (1998) · Stochastic Models · doi:10.1080/15326349808807471 · Cited by 242
Inference from Gene Trees in a Subdivided Population
Bahlo, M., & Griffiths, R. (2000) · Theoretical Population Biology · doi:10.1006/tpbi.1999.1447 · Cited by 231
Estimating Allele Age
Slatkin, M., & Rannala, B. H. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.225 · Cited by 235
Mutations in KLHL40 Are a Frequent Cause of Severe Autosomal-Recessive Nemaline Myopathy
Ravenscroft, G., Miyatake, S., Lehtokari, V., Todd, E. J., Vornanen, P., Yau, K. S., Hayashi, Y. K., Miyake, N., Tsurusaki, Y., Doi, H., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.05.004 · Cited by 226
Distinguishing between selective sweeps from standing variation and from a de novo mutation
Peter, B. M., Huerta-Sanchez, E., & Nielsen, R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003011 · Cited by 193
Adaptation and Constraint at Toll-Like Receptors in Primates
Wlasiuk, G., & Nachman, M. W. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq104 · Cited by 184
The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation
Rouzine, I. M., Brunet, É., & Wilke, C. O. (2007) · Theoretical Population Biology · doi:10.1016/j.tpb.2007.10.004 · Cited by 175
Demography and the Age of Rare Variants
Mathieson, I., & McVean, G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004528 · Cited by 147
Natural Selection and Population History in the Human Angiotensinogen Gene (AGT): 736 Complete AGT Sequences in Chromosomes from Around the World
Nakajima, T., Wooding, S., Sakagami, T., Emi, M., Tokunaga, K., Tamiya, G., Ishigami, T., Umemura, S., Munkhbat, B., Jin, F., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/420793 · Cited by 133
Estimating the age of rare disease mutations: the example of Triple-A syndrome
Génin, E., Pelet, A., Begeot, F., Lyonnet, S., & Abel, L. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.017962 · Cited by 125
Mosaic genome evolution in a recent and rapid avian radiation
Stryjewski, K. F., & Sorenson, M. D. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0364-7 · Cited by 123
How chromosomal inversions reorient the evolutionary process
Berdan, E. L., Barton, N., Butlin, R. K., Charlesworth, B., Faria, R., Fragata, I., Gilbert, K. J., Jay, P., Kapun, M., Lotterhos, K. E., et al. (2023) · Journal of Evolutionary Biology · doi:10.1111/jeb.14242 · Cited by 136
Multilocus Analysis of Introgression Between Two Sympatric Sister Species of Drosophila: Drosophila yakuba and D. santomea
Llopart, A., Lachaise, D., & Coyne, J. A. (2005) · Genetics · doi:10.1534/genetics.104.033597 · Cited by 122
Two additional potential retrotransposons isolated from a human L1 subfamily that contains an active retrotransposable element.
Dombroski, B. A., Scott, A. F., & Kazazian, H. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6513 · Cited by 119
Long‐distance gene flow and cross‐Andean dispersal of lowland rainforest bees (Apidae: Euglossini) revealed by comparative mitochondrial DNA phylogeography
Dick, C. W., Roubik, D. W., Gruber, K. F., & Bermingham, E. (2004) · Molecular Ecology · doi:10.1111/j.1365-294x.2004.02374.x · Cited by 113
Recent LTR retrotransposon insertion contrasts with waves of non-LTR insertion since speciation in Drosophila melanogaster
Bergman, C., & Bensasson, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702552104 · Cited by 101
Genetic Structure of the Ancestral Population of Modern Humans
Ziętkiewicz, E., Yotova, V., Jarník, M., Korab-Laskowska, M., Kídd, K. K., Modiano, D., Scozzari, R., Stoneking, M., Tishkoff, S. A., Batzer, M. A., et al. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006371 · Cited by 100
Patterns of polymorphism and linkage disequilibrium suggest independent origins of the human growth hormone gene cluster.
Chakravarti, A., Phillips, J. A., Mellits, K. H., Buetow, K. H., & SEEBURG, P. H. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6085 · Cited by 100
Dating Rare Mutations from Small Samples with Dense Marker Data
Gandolfo, L. C., Bahlo, M., & Speed, T. P. (2014) · Genetics · doi:10.1534/genetics.114.164616 · Cited by 95
A History of Recurrent Positive Selection at the Toll-Like Receptor 5 in Primates
Wlasiuk, G., Khan, S., Switzer, W. M., & Nachman, M. W. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp018 · Cited by 93
The frequency spectrum of a mutation, and its age, in a general diffusion model
Griffiths, R. (2003) · Theoretical Population Biology · doi:10.1016/s0040-5809(03)00075-3 · Cited by 93
Intron presence–absence polymorphism in Drosophila driven by positive Darwinian selection
Llopart, A., Comeron, J. M., Brunet, F., Lachaise, D., & Long, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122570299 · Cited by 92
Cladistic Structure Within the HumanLipoprotein LipaseGene and Its Implications for Phenotypic Association Studies
Templeton, A. R., Weiss, K. M., Nickerson, D. A., Boerwinkle, E., & Sing, C. F. (2000) · Genetics · doi:10.1093/genetics/156.3.1259 · Cited by 91
Polymorphism in the activity of human crossover hotspots independent of local DNA sequence variation
Neumann, R., & Jeffreys, A. J. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl063 · Cited by 93
Integrating the processes in the evolutionary system of domestication
Allaby, R. G. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erp382 · Cited by 89
Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate
Feng, C., Pettersson, M. E., Lamichhaney, S., Rubin, C., Rafati, N., Casini, M., Folkvord, A., & Andersson, L. (2017) · eLife · doi:10.7554/elife.23907 · Cited by 83
Characterization of Genetic Diversity in the Nematode Pristionchus pacificus from Population-Scale Resequencing Data
Rödelsperger, C., Neher, R. A., Weller, A. M., Eberhardt, G., Witte, H., Mayer, W. E., Dieterich, C., & Sommer, R. J. (2014) · Genetics · doi:10.1534/genetics.113.159855 · Cited by 83
Simulating genealogies of selected alleles in a population of variable size
Slatkin, M. (2001) · Genetics Research · doi:10.1017/s0016672301005183 · Cited by 82
Modes of speciation and the neutral theory of biodiversity
Etienne, R. S., Apol, M. E. F., Olff, H., & Weissing, F. J. (2007) · Oikos · doi:10.1111/j.0030-1299.2007.15438.x · Cited by 81
The age of an allele in a finite population
Maruyama, T. (1974) · Genetics Research · doi:10.1017/s0016672300014750 · Cited by 80
Genome‐wide association analysis for quantitative trait loci influencing W arner– B ratzler shear force in five taurine cattle breeds
McClure, M. C., Ramey, H. R., Rolf, M. M., McKay, S., Decker, J. E., Chapple, R. H., Kim, J. W., Taxis, T. M., Weaber, R. L., Schnabel, R. D., et al. (2012) · Animal Genetics · doi:10.1111/j.1365-2052.2012.02323.x · Cited by 80
Lines-of-descent and genealogical processes, and their applications in population genetics models
Tavaré, S. (1984) · Advances in Applied Probability · doi:10.1017/s000186780002228x · Cited by 67
An Age-of-Allele Test of Neutrality for Transposable Element Insertions
Blumenstiel, J. P., Chen, X., He, M., & Bergman, C. (2013) · Genetics · doi:10.1534/genetics.113.158147 · Cited by 66
A variant-centric perspective on geographic patterns of human allele frequency variation
Biddanda, A., Rice, D. P., & Novembre, J. (2020) · eLife · doi:10.7554/elife.60107 · Cited by 67
A Method for Detecting Recent Selection in the Human Genome From Allele Age Estimates
Toomajian, C., Ajioka, R. S., Jorde, L. B., Kushner, J. P., & Kreitman, M. (2003) · Genetics · doi:10.1093/genetics/165.1.287 · Cited by 63
Genetics of gout
Choi, H. K., Zhu, Y., & Mount, D. B. (2010) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32833645e8 · Cited by 65
Conditional Genealogies and the Age of a Neutral Mutant
Wiuf, C., & Donnelly, P. (1999) · Theoretical Population Biology · doi:10.1006/tpbi.1998.1411 · Cited by 65
The Evolution of Isochores: Evidence From SNP Frequency Distributions
Lercher, M. J., Smith, N. G. C., Eyre‐Walker, A., & Hurst, L. D. (2002) · Genetics · doi:10.1093/genetics/162.4.1805 · Cited by 65
Empirical Distributions of FST from Large-Scale Human Polymorphism Data
Elhaik, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049837 · Cited by 60
Spatial and Temporal Distribution of the Neutral Polymorphisms in the Last ZFX Intron: Analysis of the Haplotype Structure and Genealogy
Jaruzelska, J., Ziętkiewicz, E., Batzer, M. A., Cole, D. E. C., Moisan, J., Scozzari, R., Tavaré, S., & Labuda, D. (1999) · Genetics · doi:10.1093/genetics/152.3.1091 · Cited by 63
Complex Signatures of Selection and Gene Conversion in the Duplicated Globin Genes of House Mice
Storz, J. F., Baze, M. M., Waite, J. L., Hoffmann, F. G., Opazo, J. C., & Hayes, J. P. (2007) · Genetics · doi:10.1534/genetics.107.078550 · Cited by 63
Mismatch repair genes founder mutations and cancer susceptibility in Lynch syndrome
Ponti, G., Castellsagué, E., Ruini, C., Percesepe, A., & Tomasi, A. (2014) · Clinical Genetics · doi:10.1111/cge.12529 · Cited by 61
Linkage disequilibrium and age estimates of a deletion polymorphism (1597ΔC) in HLA-G suggest non-neutral evolution
Aldrich, C., Wambebe, C. O., Odama, L. E., Rienzo, A. D., & Ober, C. (2002) · Human Immunology · doi:10.1016/s0198-8859(02)00377-4 · Cited by 61
The GenoChip: A New Tool for Genetic Anthropology
Elhaik, E., Greenspan, E., Staats, S., Krahn, T., Tyler‐Smith, C., Xue, Y., Tofanelli, S., Francalacci, P., Cucca, F., Pagani, L., et al. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt066 · Cited by 59
Surprising Fitness Consequences of GC-Biased Gene Conversion: I. Mutation Load and Inbreeding Depression
Glémin, S. (2010) · Genetics · doi:10.1534/genetics.110.116368 · Cited by 61
Reversibility and the age of an allele. I. Moran's infinitely many neutral alleles model
Watterson, G. A. (1976) · Theoretical Population Biology · doi:10.1016/0040-5809(76)90018-6 · Cited by 59
Population Genomics of Daphnia pulex
Lynch, M., Gutenkunst, R. N., Ackerman, M. S., Spitze, K., Ye, Z., Maruki, T., & Jia, Z. (2016) · Genetics · doi:10.1534/genetics.116.190611 · Cited by 56
Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series.
Szöts, H., Riethmüller, G., Weiss, E. H., & Meo, T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.5.1428 · Cited by 58
ddRAD‐seq data reveal significant genome‐wide population structure and divergent genomic regions that distinguish the mallard and close relatives in North America
Lavretsky, P., DaCosta, J. M., Sorenson, M. D., McCracken, K. G., & Peters, J. L. (2019) · Molecular Ecology · doi:10.1111/mec.15091 · Cited by 56
Evolutionary Responses to a Constructed Niche: Ancient Mesoamericans as a Model of Gene-Culture Coevolution
Hünemeier, T., Amorim, C. E. G., de Azevedo, S., Contini, V., Acuña-Alonzo, V., Rothhammer, F., Dugoujon, J., Mazières, S., Barrantes, R., Villarreal-Molina, M. T., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038862 · Cited by 78
The ages of mutations in gene trees
Griffiths, R., & Tavaré, S. (1999) · The Annals of Applied Probability · doi:10.1214/aoap/1029962804 · Cited by 55
Genetic approaches in comparative and evolutionary physiology
Storz, J. F., Bridgham, J. T., Kelly, S. A., & Garland, T. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00100.2015 · Cited by 53
Positional Cloning by Linkage Disequilibrium
Maniatis, N., Collins, A. R., Gibson, J., Zhang, W., Tapper, W., & Morton, N. E. (2004) · The American Journal of Human Genetics · doi:10.1086/383589 · Cited by 54
Linkage disequilibrium maps and association mapping
Morton, N. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25032 · Cited by 50
Sequence Variation and Haplotype Structure at the Human HFE Locus
Toomajian, C., & Kreitman, M. (2002) · Genetics · doi:10.1093/genetics/161.4.1609 · Cited by 50
Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps
Zhang, W., Collins, A., Gibson, J., Tapper, W. J., Hunt, S., Deloukas, P., Bentley, D. R., & Morton, N. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408251102 · Cited by 49
A NOTE ON THE SPEED OF GENE FREQUENCY CHANGES IN REVERSE DIRECTIONS IN A FINITE POPULATION
Maruyama, T., & Kimura, M. (1974) · Evolution · doi:10.1111/j.1558-5646.1974.tb00736.x · Cited by 49
Self-citation
The age of a rare mutant gene in a large population.
Maruyama, T. (1974) · Europe PMC (PubMed Central) · Cited by 48
The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection
Campos, J. L., & Charlesworth, B. (2019) · Genetics · doi:10.1534/genetics.119.301951 · Cited by 48
Measuring the Rates of Spontaneous Mutation From Deep and Large-Scale Polymorphism Data
Messer, P. W. (2009) · Genetics · doi:10.1534/genetics.109.105692 · Cited by 46
Genome‐wide germline analyses on cancer susceptibility and GeMDBJ database: Gastric cancer as an example
Yoshida, T., Ono, H., Kuchiba, A., Saeki, N., & Sakamoto, H. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01590.x · Cited by 49
Population relationships in the Mediterranean revealed by autosomal genetic data (Alu and Alu/STR compound systems).
González-Pérez, E., Esteban, E., Via, M., Gayà-Vidal, M., Athanasiadis, G., Dugoujon, J., Luna, F., Mesa, M., Fuster, V., Kandil, M., et al. (2010) · American Journal of Physical Anthropology · doi:10.1002/ajpa.21161 · Cited by 47
Genomics of natural populations: Evolutionary forces that establish and maintain gene arrangements in Drosophila pseudoobscura
Fuller, Z. L., Haynes, G. D., Richards, S., & Schaeffer, S. W. (2017) · Molecular Ecology · doi:10.1111/mec.14381 · Cited by 41
Part I: Ancestral Inference in Population Genetics
Tavaré, S. (2004) · Lecture notes in mathematics · doi:10.1007/978-3-540-39874-5_1 · Cited by 43
Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data
Schrodi, S. J., DeBarber, A. E., He, M. M., Ye, Z., Peissig, P. L., Wormer, J. J. V., Haws, R. M., Brilliant, M. H., & Steiner, R. D. (2015) · Human Genetics · doi:10.1007/s00439-015-1551-8 · Cited by 42
How old are quantitative trait loci and how widely do they segregate?
Kemper, K. E., Hayes, B. J., Daetwyler, H. D., & Goddard, M. E. (2015) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12152 · Cited by 42
The first arrival time and mean age of a deleterious mutant gene in a finite population.
Li, W. (1975) · PubMed · Cited by 41
Deep sequencing of natural and experimental populations of Drosophila melanogaster reveals biases in the spectrum of new mutationsPreprint
Assaf, Z. J. F., Tilk, S., Park, J., Siegal, M. L., & Petrov, D. A. (2017) · Genome Research · doi:10.1101/gr.219956.116 · Cited by 41
Species ages in neutral biodiversity models
Chisholm, R. A., & O’Dwyer, J. P. (2014) · Theoretical Population Biology · doi:10.1016/j.tpb.2014.02.002 · Cited by 40
Detecting emerging strains of tuberculosis by using spoligotypes
Tanaka, M. M., & Francis, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603130103 · Cited by 40
Estimating the Ages of Selection Signals from Different Epochs in Human History
Nakagome, S., Alkorta‐Aranburu, G., Amato, R., Howie, B., Peter, B. M., Hudson, R. R., & Rienzo, A. D. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv256 · Cited by 38
How Long Does It Take to Fix a Favorable Mutation, and Why Should We Care?
Charlesworth, B. (2020) · The American Naturalist · doi:10.1086/708187 · Cited by 38
Ewens’ sampling formula and related formulae: combinatorial proofs, extensions to variable population size and applications to ages of alleles
Griffiths, R., & Lessard, S. (2005) · Theoretical Population Biology · doi:10.1016/j.tpb.2005.02.004 · Cited by 38
The Pattern of Polymorphism on Human Chromosome 21Preprint
印南, 秀., Padhukasahasram, B., & Nordborg, M. (2003) · Genome Research · doi:10.1101/gr.466303 · Cited by 37
Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations
Lachance, J. (2010) · BMC Medical Genomics · doi:10.1186/1755-8794-3-57 · Cited by 36
Linkage disequilibrium between rare mutations
Good, B. H. (2022) · Genetics · doi:10.1093/genetics/iyac004 · Cited by 39
Reversibility and the age of an allele II. Two-allele models, with selection and mutation
Watterson, G. A. (1977) · Theoretical Population Biology · doi:10.1016/0040-5809(77)90041-7 · Cited by 36
Apparent Variation in Neanderthal Admixture among African Populations is Consistent with Gene Flow from Non-African Populations
Wang, S., Lachance, J., Tishkoff, S. A., Hey, J., & Xing, J. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt160 · Cited by 36
Genetic diversity patterns at the human clock gene period 2 are suggestive of population-specific positive selection
Cruciani, F., Trombetta, B., Labuda, D., Modiano, D., Torroni, A., Costa, R., & Scozzari, R. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.105 · Cited by 33
Life history complementarity and the maintenance of biodiversity
Jops, K., & O’Dwyer, J. P. (2023) · Nature · doi:10.1038/s41586-023-06154-w · Cited by 33
A Bayesian method for jointly estimating allele age and selection intensity
SLATKIN, M. (2008) · Genetics Research · doi:10.1017/s0016672307008944 · Cited by 33
The effect of recurrent mutation on the frequency spectrum of a segregating site and the age of an allele
Jenkins, P. A., & Song, Y. S. (2011) · Theoretical Population Biology · doi:10.1016/j.tpb.2011.04.001 · Cited by 32
Allele age and a test for selection on rare alleles
Slatkin, M. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0729 · Cited by 32

Authors: Kimura, M., & Ohta, T.
Affiliations: National Institute of Genetics (JP)
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1973-09-01
Volume: 75
Issue: 1
Pages: 199-212
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/75.1.199
OpenAlex: W2144162032
Cited by: 241
References: 5
Citations by year: 2026: 2 · 2025: 12 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 7 · 2012: 10
FWCI: 3.43
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Physical Sciences › Mathematics › Mathematical Physics › Stochastic processes and statistical mechanics
Keywords: effective population size, mutation rate, genetic drift, diffusion equation, first arrival time, neutral selection
MeSH terms: Analysis of Variance, Gene Frequency, Genetics, Population, Mathematics, Mutation, Polymorphism, Genetic, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

THE AGE OF A NEUTRAL MUTANT PERSISTING IN A FINITE POPULATION

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks