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THE GENETIC COVARIANCE BETWEEN CHARACTERS MAINTAINED BY PLEIOTROPIC MUTATIONS
Abstract
A statistical genetic model of a multivariate phenotype i s derived to investigate the covariation of pleiotropic mutations with additive effects under the combined action of phenotypic selection, linkage and the mating system. Equilibrium formulas for large, randomly mating populations demonstrate that, when selection on polygenic variation is much smaller than twice the harmonic mean recombination rate between loci with interacting fitnesses, linkage disequilibrium is negligible and pleiotropy is the main cause of genetic correlations between characters. Under these conditions, approximate expressions of or the dynamics of the genetic covariances due to pleiotropic mutations are obtained. Patterns of genetic covariance between characters and their evolution are discussed with reference to data on polygenic mutation, chromosomal organization and morphological integration.
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Citations
Cited by
The measurement of selection on correlated characters
Lande, R., & Arnold, S. J. (1983) · Evolution · doi:10.1111/j.1558-5646.1983.tb00236.x · Cited by 5,437
Self-citationQUANTITATIVE GENETIC ANALYSIS OF MULTIVARIATE EVOLUTION, APPLIED TO BRAIN:BODY SIZE ALLOMETRY
Lande, R. (1979) · Evolution · doi:10.1111/j.1558-5646.1979.tb04694.x · Cited by 2,648
Self-citationQuantitative genetics and developmental constraints on evolution by selection
Cheverud, J. M. (1984) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(84)80050-8 · Cited by 710
EVOLUTIONARY QUANTITATIVE GENETICS: HOW LITTLE DO WE KNOW?
Barton, N. H., & Turelli, M. (1989) · Annual Review of Genetics · doi:10.1146/annurev.ge.23.120189.002005 · Cited by 686
Optimally, mutation and the evolution of ageing
Partridge, L., & Barton, N. H. (1993) · Nature · doi:10.1038/362305a0 · Cited by 668
Metadata
- Authors
- Lande, R.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-01-01
- Volume
- 94
- Issue
- 1
- Pages
- 203-215
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1931969146
- Cited by
- 687
- References
- 0
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE GENETIC COVARIANCE BETWEEN CHARACTERS MAINTAINED BY PLEIOTROPIC MUTATIONS. https://app.cochat.ai/papers/10.1093/genetics/94.1.203
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- Lande, R. (1980). THE GENETIC COVARIANCE BETWEEN CHARACTERS MAINTAINED BY PLEIOTROPIC MUTATIONS. Genetics. https://doi.org/10.1093/genetics/94.1.203
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
