EVOLUTIONARY QUANTITATIVE GENETICS: HOW LITTLE DO WE KNOW?
Abstract
Our emphasis is on the genetic basis of quantitative variation, and its effects on the evolution of quantitative. Our review indicates that few experiments approach basic issues such as the number of loci that contribute to within-population variation, the rate of polygenic mutation, the extent of pleiotropy, the mechanisms that maintain additive variance, and the reasons for reduced fitness of extreme phenotypes
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Because disease reduces fitness, variants that promote disease should be selected against and therefore should not be common.
“Since disease is deleterious to fitness, variants that promote disease should be selected against, and hence disease-promoting variants should not be common3,26,27.”
From Rare and common variants: twenty arguments (2012) · cites this paper as [27]
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Genetic correlations, tradeoffs and environmental variation
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A pessimistic estimate of the time required for an eye to evolve
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Comparing Mutational Variabilities
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A Quantitative-Genetic Perspective on Conservation Issues
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A population genetic interpretation of GWAS findings for human quantitative traits
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New Answers for Old Questions: The Evolutionary Quantitative Genetics of Wild Animal Populations
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Lifetime Reproductive Success and Heritability in Nature
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Natural and sexual selection on many loci.
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Self-citationTheoretical models of selection and mutation on quantitative traits
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Self-citationFinding the molecular basis of quatitative traits: successes and pitfalls
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Local Adaptation by Alleles of Small Effect
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HOST RACE RADIATION IN THE SOAPBERRY BUG: NATURAL HISTORY WITH THE HISTORY
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Genetic and statistical analyses of strong selection on polygenic traits: what, me normal?
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Self-citationTufto, J. (2000) · The American Naturalist · doi:10.1086/303381 · Cited by 275 · see citing works
Rapid evolution of quantitative traits: theoretical perspectives
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Familiarity leads to female mate preference for novel males in the guppy, Poecilia reticulata
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FORUM: INSECTS AND TEMPERATURE—A GENERAL THEORY
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Mapping quantitative trait loci in plants: uses and caveats for evolutionary biology
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Potential and limits for rapid genetic adaptation to warming in a Great Barrier Reef coral
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Self-citationFITNESS SENSITIVITY AND THE CANALIZATION OF LIFE-HISTORY TRAITS
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Effects of P element insertions on quantitative traits in Drosophila melanogaster.
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THE EVOLUTION OF ENDOTHERMY: TESTING THE AEROBIC CAPACITY MODEL
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Evolutionary response of landraces to climate change in centers of crop diversity
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What does the Comparative Method Reveal About Adaptation?
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Genomic mutation rates for lifetime reproductive output and lifespan in Caenorhabditis elegans
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Analysis of quantitative trait loci that influence animal behavior
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Genetic and Environmental Control of Variation in Retinal Ganglion Cell Number in Mice
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Do molecular markers reflect patterns of differentiation in adaptive traits of conifers?
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Major quantitative trait loci affecting honey bee foraging behavior.
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Trade-offs and the evolution of host specialization
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THE MUTATION MATRIX AND THE EVOLUTION OF EVOLVABILITY
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Can Population Genetics Adapt to Rapid Evolution?
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Dynamics of polygenic characters under selection
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Self-citationPredation risk and the evolutionary ecology of reproductive behaviour
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WHY EPISTASIS IS IMPORTANT FOR SELECTION AND ADAPTATION
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QUANTITATIVE GENETICS IN PLANTS: THE EFFECT OF THE BREEDING SYSTEM ON GENETIC VARIABILITY
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A universal method for achieving increases in metabolite production
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Ising Quantum Chain is Equivalent to a Model of Biological Evolution
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Evolution in Organisms that Change Their Niches during the Life Cycle
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- Authors
- Barton, N. H., & Turelli, M.
- Affiliations
- University College London (GB)
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 1989-12
- Volume
- 23
- Issue
- 1
- Pages
- 337-370
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2153359028
- Cited by
- 686
- References
- 93
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 12 · 2023: 12 · 2022: 9 · 2021: 28 · 2020: 9 · 2019: 9 · 2018: 17 · 2017: 18 · 2016: 19 · 2015: 13 · 2014: 14 · 2013: 22 · 2012: 18
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- quantitative genetics, polygenic mutations, pleiotropy, additive genetic variance, number of loci, extreme phenotypes
- MeSH terms
- Animals, Biological Evolution, Genetics, Mutation, Phenotype, Selection, Genetic
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