The DOI matches its Crossref record.
THE GENETICS OF LEVAMISOLE RESISTANCE IN THE NEMATODE CAENORHABDITIS ELEGANS
Abstract
We have characterized a small group of genes (13 loci) in the nematode Caenorhabditis elegans that, when mutated, confer resistance to the potent anthelmintic levamisole. Mutants at the 7 loci conferring the most extreme resistance generally possess almost identical visible and pharmacological phenotypes: uncoordinated motor behavior, most severe in early larval life, extreme resistance to cholinergic agonists and sensitivity to hypo-osmotic shock. Mutants with exceptional phenotypes suggest possible functions for several of the resistance loci. The most extreme mutants can readily be selected by their drug resistance (211 mutants, as many as 74 alleles of one gene). The more common resistance loci are likely to be unessential genes, while loci identified by only a few alleles may be essential genes or genes conferring resistance only when mutated in a special way. We propose that these mutants represent a favorable system for understanding how a small group of related genes function in a simple animal. The extreme drug resistance of these mutants makes them useful tools for the genetic manipulation of C. elegans. And, as the most resistant class of mutants might lack pharmacologically functional acetylcholine receptors (Lewis e t al. 1980), these mutants may also be of some neurobiological significance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Genetic control of programmed cell death in the nematode C. elegans
Ellis, H. (1986) · Cell · doi:10.1016/0092-8674(86)90004-8 · Cited by 1,828
Guidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
Thorne, C. A., Hanson, A. J., Schneider, J., Tahinci, E., Orton, D., Cselenyi, C. S., Jernigan, K. K., Meyers, K. C., Hang, B. I., Waterson, A. G., et al. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.453 · Cited by 485
A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans
van Swinderen, B., Saifee, O., Shebester, L., Roberson, R., Nonet, M. L., & Crowder, C. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2479 · Cited by 106
Sherlekar, A. L., Janssen, A., Siehr, M. S., Koo, P. K., Caflisch, L., Boggess, M., & Lints, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060597 · Cited by 46
Metadata
- Authors
- Lewis, J. A., Wu, C.-H., Berg, H., & Levine, J. H.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-08-01
- Volume
- 95
- Issue
- 4
- Pages
- 905-928
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2130233455
- Cited by
- 324
- References
- 0
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: THE GENETICS OF LEVAMISOLE RESISTANCE IN THE NEMATODE CAENORHABDITIS ELEGANS. https://app.cochat.ai/papers/10.1093/genetics/95.4.905
- The paper
- Lewis, J. A., Wu, C.-H., Berg, H., & Levine, J. H. (1980). THE GENETICS OF LEVAMISOLE RESISTANCE IN THE NEMATODE CAENORHABDITIS ELEGANS. Genetics. https://doi.org/10.1093/genetics/95.4.905
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
