The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-Year Prospective Longitudinal Cohort Study
Abstract
SIRT1 and FOXO3 are both associated with longevity. Molecular biology research in many organisms (yeast, nematode worm Caenorhabditis elegans, and mice mammalian models) shows SIRT1 acts on the FOXO family of forkhead transcription factors to respond to oxidative stress better, shifting processes away from cell death toward stress resistance. Human population studies need epidemiologic evidence. We used an open cohort of 3 166 community-dwelling participants in China with follow-up from 2008 to 2018. The mean age at baseline was 84.6 years. In 16 375 person-years of follow-up, there were 1 968 mortality events. SIRT1 and FOXO3 exhibited Mendelian randomization as there was no correlation with each other and with baseline study population characteristics. Some SIRT1 and FOXO3 single-nucleotide polymorphisms showed protective effects for mortality risk. The FOXO3 protective effect was stronger in females, and the SIRT1 protective effect was stronger in male study participants. We did not see evidence of a synergistic effect of being carriers of both SIRT1 and FOXO3 advantageous alleles.
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“Moreover, genetic association studies in humans have implicated the FOXO3 transcription factor 132 , and genetic variants encoding components of the network in human longevity 130 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [132]
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Association of FOXO3A variation with human longevity confirmed in German centenarians
Flachsbart, F., Caliebe, A., Kleindorp, R., Blanché, H., von Eller-Eberstein, H., Nikolaus, S., Schreiber, S., & Nebel, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809594106 · Cited by 572
FOXO3: A Major Gene for Human Longevity - A Mini-Review
Morris, B. J., Willcox, D. C., Donlon, T. A., & Willcox, B. J. (2015) · Gerontology · doi:10.1159/000375235 · Cited by 353
Sex-Related Differences in Gene Expression in Human Skeletal Muscle
Welle, S., Tawil, R., & Thornton, C. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001385 · Cited by 224
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Research works printed but not linked: 23
- Brunet, 2004, Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase, Science, 303, 2011, 10.1126/science.1094637 · DOI · Paper page
- Kobayashi, 2005, SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress, Int J Mol Med, 16, 237
- Giannakou, 2004, The interaction between FOXO and SIRT1: tipping the balance towards survival, Trends Cell Biol, 14, 408, 10.1016/j.tcb.2004.07.006 · DOI
- Oellerich, 2012, FOXOs and sirtuins in vascular growth, maintenance, and aging, Circ Res, 110, 1238, 10.1161/CIRCRESAHA.111.246488 · DOI
- Kedenko, 2014, Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort, BMC Med Genet, 15, 112, 10.1186/s12881-014-0112-7 · DOI
- Zeng, 2018, Sex differences in genetic associations with longevity, JAMA Netw Open, 1, e181670, 10.1001/jamanetworkopen.2018.1670 · DOI
- Li, 2009, Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations, Hum Mol Genet, 18, 4897, 10.1093/hmg/ddp459 · DOI
- Yao, 2021, Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China, Environ Health, 20, 25, 10.1186/s12940-021-00718-x · DOI
- Willcox, 2008, FOXO3A genotype is strongly associated with human longevity, Proc Natl Acad Sci U S A, 105, 13987, 10.1073/pnas.0801030105 · DOI · Paper page
- Pawlikowska, 2009, Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity, Aging Cell, 8, 460, 10.1111/j.1474-9726.2009.00493.x · DOI
- Anselmi, 2009, Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study, Rejuvenation Res, 12, 95, 10.1089/rej.2008.0827 · DOI
- Zarulli, 2018, Women live longer than men even during severe famines and epidemics, Proc Natl Acad Sci U S A, 115, E832, 10.1073/pnas.1701535115 · DOI
- Baum, 2021, New perspective on why women live longer than men: an exploration of power, gender, social determinants, and capitals, Int J Environ Res Public Health, 18, 661, 10.3390/ijerph18020661 · DOI
- Sanese, 2019, FOXO3 on the road to longevity: lessons from SNPs and chromatin hubs, Comput Struct Biotechnol J, 17, 737, 10.1016/j.csbj.2019.06.011 · DOI
- Yoshihara, 2019, Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle, J Physiol Sci, 69, 235, 10.1007/s12576-018-0640-6 · DOI
- Morris, 2015, FOXO3: a major gene for human longevity - a mini-review, 515
- Chen, 2020, FOXO3 longevity genotype mitigates the increased mortality risk in men with a cardiometabolic disease, Aging (Albany NY), 12, 23509, 10.18632/aging.202175 · DOI
- Flachsbart, 2009, Association of FOXO3A variation with human longevity confirmed in German centenarians, Proc Natl Acad Sci U S A, 106, 2700, 10.1073/pnas.0809594106 · DOI · Paper page
- Sasaki, 2020, Estrogen–SIRT1 axis plays a pivotal role in protecting arteries against menopause-induced senescence and atherosclerosis, J Atheroscler Thromb, 27, 47, 10.5551/jat.47993 · DOI
- Barcena de Arellano, 2019, Sex differences in the aging human heart: decreased sirtuins, pro-inflammatory shift and reduced anti-oxidative defense, Aging (Albany NY), 11, 1918, 10.18632/aging.101881 · DOI
- Lee, 2017, Aging-related correlation between serum Sirtuin 1 activities and basal metabolic rate in women, but not in men, Clin Nutr Res, 6, 18, 10.7762/cnr.2017.6.1.18 · DOI
- Chen, 2020, SIRT1/FOXO3a axis plays an important role in the prevention of mandibular bone loss induced by 1,25(OH)2D deficiency, Int J Biol Sci, 16, 2712, 10.7150/ijbs.48169 · DOI
- Hori, 2013, Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress, PLoS One, 8, e73875, 10.1371/journal.pone.0073875 · DOI
Cited by
Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
Metadata
- Authors
- Ji, J. S., Liu, L., Shu, C., Yan, L. L., & Zeng, Y.
- Affiliations
- Vanke School of Public Health, Tsinghua University , Beijing , China
- Departments of Pediatrics and Systems Biology , Columbia University, New York , New York, USA
- Global Health Research Center , Duke Kunshan University, Kunshan , China
- Center for Healthy Aging and Development Studies, National School of Development, Peking University , Beijing , China
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-12-20
- Volume
- 77
- Issue
- 8
- Pages
- 1557-1563
- ISSN
- 1079-5006
- 1758-535X
- Cited by
- 19
- References
- 3
- Language
- en
- Funders
- National Key Research and Development Program of China (2018YFC2000400)
- National Natural Science Foundation of China (72061137004)
- National Institute on Aging (P01AG031719)
- National Institutes of Health
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