FOXO3: A Major Gene for Human Longevity - A Mini-Review

A C. elegans mutant that lives twice as long as wild type

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The genetics of ageing

Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

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A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562 · see citing works

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial

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Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

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Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

Liesa, M., & Shirihai, O. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.002 · Cited by 1,341 · see citing works

Akt, FoxO and regulation of apoptosis

Zhang, X., Tang, N., Hadden, T. J., & Rishi, A. K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.03.010 · Cited by 1,112 · see citing works

FOXOs: signalling integrators for homeostasis maintenance

Eijkelenboom, A., & Burgering, B. M. T. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3507 · Cited by 1,081 · see citing works

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

Paik, J.-H., Kollipara, R., Chu, G., Ji, H., Xiao, Y., Ding, Z., Miao, L., Tothova, Z., Horner, J. W., Carrasco, D. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.029 · Cited by 1,032 · see citing works

FOXO3A genotype is strongly associated with human longevity

Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983 · see citing works

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V. C., Warren, A., Huang, X., Pichaud, N., Melvin, R. G., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.009 · Cited by 904 · see citing works

Foxo3a is essential for maintenance of the hematopoietic stem cell pool

Miyamoto, K., Kazuhito, N., & Atsushi, H. (2009) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 858 · see citing works

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., et al. (2011) · Nature · doi:10.1038/nature10296 · Cited by 624 · see citing works

FOXO transcription factors: key regulators of cellular quality control

Webb, A. E., & Brunet, A. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.003 · Cited by 620 · see citing works

Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body

Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2004) · Science · doi:10.1126/science.1098219 · Cited by 577 · see citing works

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

Hubbard, B. P., & Sinclair, D. A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.12.004 · Cited by 572 · see citing works

FoxO3a Transcriptional Regulation of Bim Controls Apoptosis in Paclitaxel-treated Breast Cancer Cell Lines

Sunters, A., Fernández de Mattos, S., Stahl, M., Brosens, J. J., Zoumpoulidou, G., Saunders, C. A., Coffer, P. J., Medema, R. H., Coombes, R. C., & Lam, E. W.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309523200 · Cited by 505 · see citing works

Regulation of NF-κB, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a

Lin, L., Hron, J. D., & Peng, S. L. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.016 · Cited by 420 · see citing works

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

You, H., Pellegrini, M., Tsuchihara, K., Yamamoto, K., Häcker, G. A., Erlacher, M., Villunger, A., & Mak, T. W. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060353 · Cited by 413 · see citing works

Seven sirtuins for seven deadly diseases ofaging

Morris, B. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.525 · Cited by 380 · see citing works

Genetics of healthy aging and longevity

Brooks-Wilson, A. R. (2013) · Human Genetics · doi:10.1007/s00439-013-1342-z · Cited by 380 · see citing works

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

Chen, C.-C., Jeon, S., Bhaskar, P. T., Nogueira, V., Sundararajan, D., Tonic, I., Park, Y., & Hay, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.008 · Cited by 369 · see citing works

FOXO-dependent regulation of innate immune homeostasis

Becker, T., Loch, G., Beyer, M., Zinke, I., Aschenbrenner, A. C., Carrera, P., Inhester, T., Schultze, J. L., & Hoch, M. (2010) · Nature · doi:10.1038/nature08698 · Cited by 357 · see citing works

The FOXO3a Transcription Factor Regulates Cardiac Myocyte Size Downstream of AKT Signaling

Skurk, C., Izumiya, Y., Maatz, H., Razeghi, P., Shiojima, I., Sandri, M., Sato, K., Zeng, L., Schiekofer, S., Pimentel, D. R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500528200 · Cited by 353 · see citing works

FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress

Sengupta, A., Molkentin, J. D., Paik, J.-H., DePinho, R. A., & Yutzey, K. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.179242 · Cited by 330 · see citing works

Foxo3 is required for the regulation of oxidative stress in erythropoiesis

Marinković, D., Zhang, X., Yalcin, S., Luciano, J. P., Brugnara, C., Huber, T. L., & Ghaffari, S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31807 · Cited by 320 · see citing works

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells

Essafi, A., de Mattos, S. F., Hassen, Y., Soeiro, I., Mufti, G. J., Thomas, N. S. B., Medema, R. H., & Lam, E. W. ‐. (2005) · Oncogene · doi:10.1038/sj.onc.1208421 · Cited by 293 · see citing works

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

Sykes, S., Lane, S. W., Bullinger, L., Kalaitzidis, D., Yusuf, R., Saez, B., Ferraro, F., Mercier, F., Singh, H., Brumme, K., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.032 · Cited by 281 · see citing works

GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy

Broer, L., Buchman, A. S., Deelen, J., Evans, D. S., Faul, J. D., Lunetta, K. L., Sebastiani, P., Smith, J. A., Smith, A. V., Tanaka, T., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu166 · Cited by 279 · see citing works

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

Zhang, X., Yalcin, S., Lee, D., Yeh, T.-Y. J., Lee, S.-M., Su, J., Mungamuri, S. K., Rimmelé, P., Kennedy, M., Sellers, R. S., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2293 · Cited by 262 · see citing works

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

Dejean, A. S., Beisner, D. R., Ch’en, I. L., Kerdiles, Y. M., Babour, A., Arden, K. C., Castrillón, D. H., DePinho, R. A., & Hedrick, S. Μ. (2009) · Nature Immunology · doi:10.1038/ni.1729 · Cited by 235 · see citing works

Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway

Lee, J. C., Espéli, M., Anderson, C. A., Linterman, M. A., Pocock, J., Williams, N. J., Roberts, R. L., Viatte, S., Fu, B., Peshu, N. M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.034 · Cited by 226 · see citing works

FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

Gopinath, S. D., Webb, A. E., Brunet, A., & Rando, T. A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.02.002 · Cited by 212 · see citing works

The Search for Longevity and Healthy Aging Genes: Insights From Epidemiological Studies and Samples of Long-Lived Individuals

Murabito, J. M., Yuan, R., & Lunetta, K. L. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls089 · Cited by 200 · see citing works

FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression

Tao, R., Xiong, X., DePinho, R. A., Deng, C., & Dong, X. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.481473 · Cited by 195 · see citing works

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis

Tsuchiya, K., Tanaka, J., Yu, S., Welch, C. L., DePinho, R. A., Tabas, I. A., Tall, A. R., Goldberg, I. J., & Accili, D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.018 · Cited by 179 · see citing works

FoxO is a critical regulator of stem cell maintenance in immortal Hydra

Böhm, A.-M., Khalturin, K., Anton‐Erxleben, F., Hemmrich, G., Klostermeier, U. C., López-Quintero, J. A., Oberg, H., Puchert, M., Rosenstiel, P. C., Wittlieb, J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209714109 · Cited by 174 · see citing works

FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis

Webb, A. E., Pollina, E. A., Vierbuchen, T., Urbán, N., Ucar, D., Leeman, D. S., Martynoga, B., Sewak, M., Rando, T. A., Guillemot, F., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.035 · Cited by 164 · see citing works

A pathway that links reproductive status to lifespan in Caenorhabditis elegans

Kenyon, C. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05640.x · Cited by 163 · see citing works

The phytochemical, EGCG , extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy rats

Niu, Y., Na, L., Feng, R., Gong, L., Zhao, Y., Li, Q., Li, Y., & Sun, C. (2013) · Aging Cell · doi:10.1111/acel.12133 · Cited by 162 · see citing works

Induction of Mxi1-SRα by FOXO3a Contributes to Repression of Myc-Dependent Gene Expression

Delpuech, O., Griffiths, B. L., East, P., Essafi, A., Lam, E. W. ‐., Burgering, B. M. T., Downward, J., & Schulze, A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01789-06 · Cited by 160 · see citing works

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

Rimmelé, P., Bigarella, C. L., Liang, R. H.-S., Izac, B., Dieguez‐Gonzalez, R., Barbet, G., Donovan, M. J., Brugnara, C., Blander, J. M., Sinclair, D. A., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.015 · Cited by 154 · see citing works

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

Holstege, H., Pfeiffer, W., Sie, D., Hulsman, M., Nicholas, T. J., Lee, C. C., Ross, T., Lin, J., Miller, M. A., Ylstra, B., et al. (2014) · Genome Research · doi:10.1101/gr.162131.113 · Cited by 152 · see citing works

Sca1-Derived Cells Are a Source of Myocardial Renewal in the Murine Adult Heart

Uchida, S., Gaspari, P. D., Sawa Kostin, D., Jenniches, K., Kılıç, A., Izumiya, Y., Shiojima, I., Kreymborg, K. G., Renz, H. E., Walsh, K., et al. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.09.004 · Cited by 152 · see citing works

The Forkhead Transcription Factor FOXO3a Increases Phosphoinositide-3 Kinase/Akt Activity in Drug-Resistant Leukemic Cells through Induction of PIK3CA Expression

Hui, R. C.-Y., Gomes, A., Constantinidou, D., Costa, J. R., Karadedou, C. T., de Mattos, S. F., Wymann, M. P., Brosens, J. J., Schulze, A., & Lam, E. W. ‐. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01265-07 · Cited by 151 · see citing works

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

Yeo, H., Lyssiotis, C. A., Zhang, Y., Ying, H., Asara, J. M., Cantley, L. C., & Paik, J.-H. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.186 · Cited by 145 · see citing works

FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts

Chiribau, C. B., Cheng, L., Cucoranu, I. C., Yu, Y.-S., Clempus, R. E., & Sorescu, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710610200 · Cited by 140 · see citing works

The Hydra polyp: Nothing but an active stem cell community

Bosch, T. C. G., Anton‐Erxleben, F., Hemmrich, G., & Khalturin, K. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01143.x · Cited by 137 · see citing works

Genome‐wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

Eijkelenboom, A., Mokrý, M., de Wit, E., Smits, L. M. M., Polderman, P. E., van Triest, M. H., van Boxtel, R., Schulze, A., de Laat, W. L., Cuppen, E. P. J. G., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2012.74 · Cited by 122 · see citing works

Forkhead Transcription Factors Inhibit Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

Abid, M. R., Yano, K., Guo, S., Patel, V. I., Shrikhande, G., Spokes, K., Ferran, C. J., & Aird, W. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502149200 · Cited by 117 · see citing works

STAT3 Protein Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription Factors

Oh, H., Yu, C., Golestaneh, N., Amadi‐Obi, A., Lee, Y. S., Eseonu, A. C., Mahdi, R. M., & Egwuagu, C. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.253500 · Cited by 115 · see citing works

Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles

Furuyama, T., Yamashita, H., Kitayama, K., Higami, Y., Shimokawa, I., & Mori, N. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10213 · Cited by 114 · see citing works

Forkhead Transcription Factor FOXO3a Is a Negative Regulator of Angiogenic Immediate Early Gene CYR61, Leading to Inhibition of Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

Lee, H.-Y., Chung, J.-W., Youn, S.-W., Kim, J.-Y., Park, K.-W., Koo, B.-K., Oh, B.-H., Park, Y.-B., Chaqour, B., Walsh, K., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000257945.97958.77 · Cited by 107 · see citing works

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

Kuningas, M., Mägi, R., Westendorp, R. G. J., Slagboom, P. E., Remm, M., & van Heemst, D. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201766 · Cited by 104 · see citing works

Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry

He, Q., Morris, B. J., Grove, J., Petrovitch, H., Ross, W. G., Masaki, K., Rodríguez, B. L., Chen, R., Donlon, T. A., Willcox, D. C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094385 · Cited by 103 · see citing works

A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer

Morris, B. J. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000173509.45363.dd · Cited by 98 · see citing works

The Effect of Resveratrol on a Cell Model of Human Aging

Stefani, M., Markus, M. A., Lin, R. C. Y., Pinese, M., Dawes, I. W., & Morris, B. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.001 · Cited by 75 · see citing works

Association between Serum Interleukin-6 Concentrations and Mortality in Older Adults: The Rancho Bernardo Study

Lee, J. K., Bettencourt, R., Brenner, D. A., Le, T., Barrett-Connor, E. L., & Loomba, R. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034218 · Cited by 74 · see citing works

Association between FOXO3A gene polymorphisms and human longevity: a meta-analysis

Zhao, S., Chen, Q., Bao, J., Song, X., Hong, Y.-Q., Zhu, H., Li, C., Zhang, T., & Chen, W. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.123673 · Cited by 67 · see citing works

Regulatory effects of curcumin on lipid accumulation in monocytes/macrophages

Zingg, J.-M. A., Hasan, S. T., Cowan, D., Ricciarelli, R., Azzi, A., & Meydani, M. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23411 · Cited by 63 · see citing works

FOXO3 Gene Variants and Human Aging: Coding Variants May Not Be Key Players

Donlon, T. A., Curb, J. D., He, Q., Grove, J., Masaki, K., Rodríguez, B. L., Elliott, A., Willcox, D. C., & Willcox, B. J. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls067 · Cited by 60 · see citing works

TheFOXO3Ars2802292 G-Allele Associates with Improved Peripheral and Hepatic Insulin Sensitivity and Increased Skeletal Muscle-FOXO3AmRNA Expression in Twins

Banasik, K., Ribel‐Madsen, R., Gjesing, A. P., Thørner, L. W., Andersson, Å., Poulsen, P., Borglykke, A., Witte, D. R., Pedersen, O. B., Hansen, T. F., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0881 · Cited by 47 · see citing works

MicroRNA-217 Promotes Angiogenesis of Human Cytomegalovirus-Infected Endothelial Cells through Downregulation of SIRT1 and FOXO3A

Zhang, S., Liu, L., Wang, R.-J., Tuo, H., Guo, Y., Li, Y., Wang, D., & Wang, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083620 · Cited by 45 · see citing works

GxE Interactions between FOXO Genotypes and Tea Drinking Are Significantly Associated with Cognitive Disability at Advanced Ages in China

Zeng, Y., Chen, H., Ni, T., Ruan, R., Feng, L., Nie, C., Cheng, L., Li, Y., Tao, W., Gu, J., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu060 · Cited by 42 · see citing works

Immune regulation by Foxo transcription factors

Peng, S. L. (2007) · Autoimmunity · doi:10.1080/08916930701464913 · Cited by 42 · see citing works

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.02.001 · Cited by 41 · see citing works

Stem cells and aging from a quasi‐immortal point of view

Böhm, A.-M., Rosenstiel, P. C., & Bosch, T. C. G. (2013) · BioEssays · doi:10.1002/bies.201300075 · Cited by 30 · see citing works

FOXO in aging: Did evolutionary diversification of FOXO function distract it from prolonging life?

Schaible, R., & Sussman, M. (2013) · BioEssays · doi:10.1002/bies.201300078 · Cited by 24 · see citing works

Characterization of the rs2802292 SNP identifies FOXO3Aas a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes

Forte, G., Grossi, V., Celestini, V., Lucisano, G., Scardapane, M., Varvara, D., Patruno, M., Bagnulo, R., Loconte, D. C., Giunti, L., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-661 · Cited by 14 · see citing works

Facing up to the global challenges of ageing

Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475 · see citing works

Clinical and molecular aspects of lead toxicity: An update

Mitra, P., Sharma, S., Purohit, P., & Sharma, P. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1408562 · Cited by 390 · see citing works

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

Argentieri, M. A., Xiao, S., Bennett, D., Winchester, L. M., Nevado‐Holgado, A. J., Ghose, U., Albukhari, A., Yao, P., Mazidi, M., Lv, J., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03164-7 · Cited by 378 · see citing works

Therapeutic strategies targeting FOXO transcription factors

Calissi, G., Lam, E. W. ‐., & Link, W. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0088-2 · Cited by 336 · see citing works

FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response

Fasano, C., Disciglio, V., Bertora, S., Signorile, M. L., & Simone, C. (2019) · Cells · doi:10.3390/cells8091110 · Cited by 237 · see citing works

DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling

Zečić, A., & Braeckman, B. P. (2020) · Cells · doi:10.3390/cells9010109 · Cited by 224 · see citing works

Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system

Becker, L., Nguyen, L., Gill, J., Kulkarni, S., Pasricha, P. J., & Habtezion, A. (2018) · Gut · doi:10.1136/gutjnl-2016-312940 · Cited by 196 · see citing works

TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice

Wang, Y., Lin, Y., Wang, L., Zhan, H., Luo, X., Zeng, Y., Wu, W., Zhang, X., & Wang, F. (2020) · Aging · doi:10.18632/aging.104104 · Cited by 196 · see citing works

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188 · see citing works

Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability

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Characterization of the direct targets of<scp>FOXO</scp>transcription factors throughout evolution

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