The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
The Relationship Between Intervening Hospitalizations and Transitions Between Frailty States
Open accessAbstract
BACKGROUND: Frailty among older persons is a dynamic process, characterized by frequent transitions between frailty states over time. We performed a prospective longitudinal study to evaluate the relationship between intervening hospitalizations and these transitions. METHODS: We studied 754 nondisabled community-living persons, aged 70 years or older. Frailty, assessed every 18 months for 108 months, was defined on the basis of muscle weakness, exhaustion, low physical activity, shrinking, and slow walking speed. Participants were classified as frail if they met three or more of these criteria, prefrail if they met one or two of the criteria, or nonfrail if they met none of the criteria. Hospitalizations were ascertained every month for a median of 108 months. RESULTS: The exposure rates (95% confidence interval) of hospitalization per 1,000 months, based on frailty status at the start of each 18-month interval, were 19.7 (16.2-24.0) nonfrail, 32.9 (29.8-36.2) prefrail, and 57.2 (52.9-63.1) frail. The likelihood of transitioning from states of greater frailty to lesser frailty (ie, recovering) was consistently lower based on exposure to intervening hospitalizations, with adjusted hazard ratios per each hospitalization ranging from 0.46 (95% confidence interval: 0.21-1.03) for the transition from frail to nonfrail states to 0.52 (95% confidence interval: 0.42-0.65) for the transition from prefrail to nonfrail states. Hospitalization had more modest and less consistent effects on transitions from states of lesser frailty to greater frailty. Nonetheless, transitions from nonfrail to frail states were uncommon in the absence of a hospitalization. CONCLUSIONS: Recovery from prefrail and frail states is substantially diminished by intervening hospitalizations. These results provide additional evidence highlighting the adverse consequences of hospitalization in older persons.
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“Deconditioning is also relevant when older adults are hospitalized, ill, or temporarily immobilized, thereby disrupting their PA [266,267].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [266]
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“Deconditioning is also relevant when older adults are hospitalized, ill, or temporarily immobilized, thereby disrupting their PA [266,267].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [266]
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Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m255 · Cited by 4,032
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The Robust Inference for the Cox Proportional Hazards Model
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Inouye, S. K. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052321 · Cited by 2,091
The Frailty Syndrome: Definition and Natural History
Xue, Q. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.08.009 · Cited by 2,067
The Care Transitions Intervention: Results of a Randomized Controlled Trial
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Research works printed but not linked: 4
- Gill, 2006, Archives of Internal Medicine, 166, 418, 10.1001/.418 · DOI · Paper page
- 2001, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56A, M146
- 2002, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 57A, M449
- 2009, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 64, 1049
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Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Woodhouse, L. J., Rodríguez‐Mañas, L., Fried, L. P., Woo, J., Aprahamian, I., Sanford, A. M., Lundy, J., et al. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1273-z · Cited by 1,135
Schouten, H. J., Geersing, G., Koek, H. L., Zuithoff, N. P. A., Janssen, K. J. M., Douma, R. A., van Delden, J. J. M., Moons, K. G. M., & Reitsma, J. B. (2013) · BMJ · doi:10.1136/bmj.f2492 · Cited by 346
Transitions in Frailty States Among Community-Living Older Adults and Their Associated Factors
Lee, J. S. W., Auyeung, T., Leung, J. C. S., Kwok, T. C. Y., & Woo, J. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.12.002 · Cited by 323
Izquierdo, M., de Souto Barreto, P., Arai, H., Bischoff-Ferrari, H. A., Cadore, E. L., Cesari, M., Chen, L.-K., Coen, P. M., Courneya, K. S., Duque, G., et al. (2025) · The Journal of nutrition, health and aging · doi:10.1016/j.jnha.2024.100401 · Cited by 273
Multisystem physiological perspective of human frailty and its modulation by physical activity
Taylor, J. A., Greenhaff, P. L., Bartlett, D. B., Jackson, T., Duggal, N. A., & Lord, J. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00037.2021 · Cited by 218
Metadata
- Authors
- Gill, T. M., Gahbauer, E. A., Han, L., & Allore, H. G.
- Affiliations
- Yale University (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-17
- Volume
- 66A
- Issue
- 11
- Pages
- 1238-1243
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC3193526
- OpenAlex
- W2112937554
- Cited by
- 142
- References
- 47
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 8 · 2016: 5 · 2015: 14 · 2014: 11 · 2013: 11 · 2012: 7
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R37AG017560, K24AG021507, R37AG17560, P30 AG21342, P30AG021342)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- frailty, pre-frailty, hospitalization, frailty transitions, older adults, community-dwelling older adults, Fried frailty phenotype
- MeSH terms
- Aged, Aged, 80 and over, Female, Health Status, Hospitalization, Humans, Male, Prospective Studies, Frail Elderly
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