The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults
Open accessAbstract
BACKGROUND: Lower ambulatory performance with aging may be related to a reduced oxidative capacity within skeletal muscle. This study examined the associations between skeletal muscle mitochondrial capacity and efficiency with walking performance in a group of older adults. METHODS: Thirty-seven older adults (mean age 78 years; 21 men and 16 women) completed an aerobic capacity (VO2 peak) test and measurement of preferred walking speed over 400 m. Maximal coupled (State 3; St3) mitochondrial respiration was determined by high-resolution respirometry in saponin-permeabilized myofibers obtained from percutanous biopsies of vastus lateralis (n = 22). Maximal phosphorylation capacity (ATPmax) of vastus lateralis was determined in vivo by (31)P magnetic resonance spectroscopy (n = 30). Quadriceps contractile volume was determined by magnetic resonance imaging. Mitochondrial efficiency (max ATP production/max O2 consumption) was characterized using ATPmax per St3 respiration (ATPmax/St3). RESULTS: In vitro St3 respiration was significantly correlated with in vivo ATPmax (r (2) = .47, p = .004). Total oxidative capacity of the quadriceps (St3*quadriceps contractile volume) was a determinant of VO2 peak (r (2) = .33, p = .006). ATPmax (r (2) = .158, p = .03) and VO2 peak (r (2) = .475, p < .0001) were correlated with preferred walking speed. Inclusion of both ATPmax/St3 and VO2 peak in a multiple linear regression model improved the prediction of preferred walking speed (r (2) = .647, p < .0001), suggesting that mitochondrial efficiency is an important determinant for preferred walking speed. CONCLUSIONS: Lower mitochondrial capacity and efficiency were both associated with slower walking speed within a group of older participants with a wide range of function. In addition to aerobic capacity, lower mitochondrial capacity and efficiency likely play roles in slowing gait speed with age.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Collectively, these age-related skeletal muscle deficits contribute to reductions in cardiorespiratory fitness (peak oxygen uptake [Vo2 peak]), exercise tolerance, and overall physical function (9, 10).”
From Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age (2015) · cites this paper as [10]
In the citing paper
“recent studies have shown that loss of mitochondrial energetics in sub-optimal aging contributes to slower walking speed [[355], [356], [357], [358]], fatigability [359], multimorbidity [360], frailty [361] and sarcopenia [345,362].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [356]
In the citing paper
“For instance, in a prospective cohort study, walking reduced the risk of dementia in a dose-dependent manner, with walking less than 0.25 miles per day compared to walking > 2 miles per day, controlling for other risk factors [356].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [356]
In the citing paper
“For instance, in a prospective cohort study, walking reduced the risk of dementia in a dose-dependent manner, with walking less than 0.25 miles per day compared to walking > 2 miles per day, controlling for other risk factors [356].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [356]
In the citing paper
“Thus, evidence to date strongly implicates the mitochondria as having a pivotal role in the pathogenesis of age-related functional decline,(Coen, Jubrias, Distefano, Amati, Mackey, Glynn, Manini, Wohlgemuth, Leeuwenburgh, Cummings, Newman, Ferrucci, Toledo, Shankland, Conley, and Goodpaster 2013) and reductions in autophagy appear to be a critical biological mechanism affecting the collective”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Coen et al. 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792
Self-citation(2014) · Medical Entomology and Zoology · Cited by 9,400
Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E., & Wallace, R. B. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320902 · Cited by 4,083
Self-citationThe physical activity scale for the elderly (PASE): Development and evaluation
Washburn, R. A., Smith, K. W., Jette, A. M., & Janney, C. A. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90053-4 · Cited by 3,256
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · cited 1×
“AGING is associated with reduced mitochondrial capacity (1,2) and loss of muscle mass and strength (3,4), which could potentially predispose individuals to frailty and a slower preferential walking speed (5,6).”
BackgroundSelf-citationMitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E. M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., & on Behalf of the Health, A. A. B. C. S. I. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.1.72 · Cited by 1,692
Self-citationVisser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403
Self-citationDecline in skeletal muscle mitochondrial function with aging in humans
Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333
Physical performance measures in the clinical setting
Studenski, S., Perera, S., Wallace, D., Chandler, J. M., Duncan, P. W., Rooney, E., Fox, M., & Guralnik, J. M. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51104.x · Cited by 1,218
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Conley, 2000, Oxidative capacity and ageing in human muscle, J Physiol, 526, 203, 10.1111/j.1469-7793.2000.t01-1-00203.x · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 323
In vivoevidence of an age-related increase in ATP cost of contraction in the plantar flexor muscles
Layec, G., Trinity, J. D., Hart, C. R., Kim, S., Groot, H. J., Fur, Y. L., Sorensen, J. R., Jeong, E., & Richardson, R. S. (2013) · Clinical Science · doi:10.1042/cs20130442 · Cited by 43
“However, although the effects of aging on the actual efficiency of locomotor muscles has received considerable attention [3-6], this topic is still controversial [7].”
BackgroundLagerwaard, B., Nieuwenhuizen, A. G., de Boer, V. C. J., & Keijer, J. (2019) · GeroScience · doi:10.1007/s11357-019-00145-4 · Cited by 43
Layne, A. S., Hsu, F., Blair, S. N., Chen, S.-H., Dungan, J., Fielding, R. A., Glynn, N. W., Hajduk, A. M., King, A. C., Manini, T. M., et al. (2016) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2016.07.019 · Cited by 47
Self-citationKonopka, A. R., Laurin, J. L., Musci, R. V., Wolff, C. A., Reid, J. J., Biela, L. M., Zhang, Q., Peelor, F. F., Melby, C. L., Hamilton, K. L., et al. (2017) · GeroScience · doi:10.1007/s11357-017-9968-8 · Cited by 43
“With increasing age, there is an increase in oxidative stress and inflammation and a decline in myofiber (Ochala et al. 2007) and mitochondrial (Coen et al. 2013; Santanasto et al. 2015) function.”
BackgroundATP and NAD+ Deficiency in Parkinson’s Disease
Mischley, L. K., Shankland, E. G., Liu, S. Z., Bhayana, S., Fox, D. J., & Marcinek, D. J. (2023) · Nutrients · doi:10.3390/nu15040943 · Cited by 41
“In human skeletal muscle, ATPmax is correlated with mitochondrial content and maximum in vitro respiration and thus provides a non-invasive measure of mitochondrial capacity [17,18].”
BackgroundSelf-citationHinkley, J. M., Yu, G. X., Standley, R. A., Distéfano, G., Tolstikov, V., Narain, N. R., Greenwood, B. P., Karmacharya, S., Kiebish, M. A., Carnero, E. Á., et al. (2023) · The Journal of Physiology · doi:10.1113/jp284142 · Cited by 44
Self-citationRubenstein, A. B., Hinkley, J. M., Nair, V. D., Nudelman, G., Standley, R. A., Yi, F., Yu, G., Trappe, T. A., Bamman, M. M., Trappe, S. W., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00378.2021 · Cited by 40
Self-citationBharadwaj, M. S., Tyrrell, D. J., Leng, I., Demons, J. L., Lyles, M. F., Carr, J. J., Nicklas, B. J., & Molina, A. J. A. (2015) · BMC Obesity · doi:10.1186/s40608-015-0070-4 · Cited by 41
“Recent studies have highlighted the significance of skeletal muscle mitochondrial function in the physical ability of older adults [31, 39–41].”
BackgroundLagerwaard, B., Keijer, J., McCully, K. K., de Boer, V. C. J., & Nieuwenhuizen, A. G. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04169-8 · Cited by 40
Skeletal muscle mitochondria in health and disease
Mario, A. D., Gherardi, G., Rizzuto, R., & Mammucari, C. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102357 · Cited by 42
Newman, A. B. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad021 · Cited by 39
Self-citationRoshanravan, B., Liu, S. Z., Ali, A. S., Shankland, E. G., Goss, C., Amory, J. K., Robertson, H. T., Marcinek, D. J., & Conley, K. E. (2021) · PLOS ONE · doi:10.1371/journal.pone.0253849 · Cited by 38
“Mitochondrial dysfunction is also associated with sarcopenia and impaired physical endurance across multiple populations [7, 8].”
BackgroundInfluentialSelf-citationMitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing
Broome, S. C., Whitfield, J., Karagounis, L. G., & Hawley, J. A. (2024) · Sports Medicine · doi:10.1007/s40279-024-02072-7 · Cited by 43
“…in mitochondrial bioenergetics (e.g., mitochondrial capacity and efficiency) have been proposed as a factor underpinning low physical function [22, 23], fatiguability [24], and loss of exercise efficiency (defined as the ratio of mechanical work rate over energy expenditure) with ageing [25].”
BackgroundSkeletal muscle work efficiency with age: the role of non-contractile processes
Layec, G., Hart, C. R., Trinity, J. D., Fur, Y. L., Jeong, E.-K., & Richardson, R. S. (2014) · Clinical Science · doi:10.1042/cs20140274 · Cited by 37
Interpretation of Near-Infrared Spectroscopy (NIRS) Signals in Skeletal Muscle
Sanni, A. A., & McCully, K. (2019) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk4020028 · Cited by 32
“A key to muscle contractions is the production of chemical energy (ATP) primarily from oxidative metabolism in muscle mitochondria [2,3].”
BackgroundAdelnia, F., Urbanek, J. K., Osawa, Y., Shardell, M. D., Brennan, N. A., Fishbein, K. W., Spencer, R. G. S., Simonsick, E. M., Schrack, J. A., & Ferrucci, L. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15991 · Cited by 37
“Data were collected using a standardized protocol described previously.(14,15) Briefly, participants were instructed to perform an in-magnet rapid knee extension exercise of an average duration of 30 seconds while a total of 75 pulseacquired (31)P-MRS acquisitions with 6-second time resolution were collected for 60 se…”
MethodSelf-citationBrown, P. J., Ciarleglio, A., Roose, S. P., Garcia, C. M., Chung, S., Fernandes, S. M. S. R., & Rutherford, B. R. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab338 · Cited by 37
Extracellular matrix/mitochondria pathway: A novel potential target for sarcopenia
Melouane, A., Yoshioka, M., & St‐Amand, J. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.10.007 · Cited by 35
Layec, G., Gifford, J. R., Trinity, J. D., Hart, C. R., Garten, R. S., Park, S., Fur, Y. L., Jeong, E. K., & Richardson, R. S. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00028.2016 · Cited by 34
“Interestingly, some validation with in vitro techniques has been performed for these (31)P-MRS-based approaches (5, 28, 32, 42).”
MethodResultCardiopulmonary Exercise Testing for Preoperative Evaluation: What Does the Future Hold?
Otto, J. M., Levett, D. Z. H., & Grocott, M. P. W. (2020) · Current anesthesiology reports · doi:10.1007/s40140-020-00373-x · Cited by 35
The link between Mitochondria and Sarcopenia
Kamarulzaman, N. T., & Makpol, S. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01062-7 · Cited by 33
“The impact of mitochondrial bioenergetic decline on muscle ageing correlates with ATP synthesis, oxygen consumption, and preferred walking speed in healthy elderly (Choi et al. 2016; Coen et al. 2013; Gonzalez-Freire et al. 2018).”
Herbst, A. J., Prior, S. J., Lee, C. C., Aiken, J. M., McKenzie, D. I., Hoang, A. N., Liu, N., Chen, X., Xun, P., Allison, D. B., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00351-z · Cited by 38
Kunz, H., Port, J. D., Kaufman, K. R., Jatoi, A., Hart, C. R., Gries, K. J., Lanza, I. R., & Kumar, R. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00746.2021 · Cited by 32
Long-term aerobic exercise preserves muscle mass and function with age
Laurin, J. L., Reid, J. J., Lawrence, M. M., & Miller, B. F. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.04.019 · Cited by 36
Pechstein, A. E., Gollie, J. M., & Guccione, A. A. (2020) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk5040078 · Cited by 33
Lee, H., Kim, Y. I., Nirmala, F. S., Kim, J., Seo, H., Ha, T. Y., Jang, Y. J., Jung, C. H., & Ahn, J. (2021) · Aging · doi:10.18632/aging.202617 · Cited by 31
“com 4882 AGING mitochondrial dysfunction is the most frequently implicated mechanism of aging muscle atrophy [8].”
BackgroundDeep learning analysis and age prediction from shoeprints
Hassan, M. A., Wang, Y., Wang, D., Li, D., Liang, Y., Zhou, Y., & Xu, D. H. (2021) · Forensic Science International · doi:10.1016/j.forsciint.2021.110987 · Cited by 32
“The energy cost for muscle movements during walking is high in children and steadily decreases over age [43], [44] which can be reflected in the imprinted ar X iv :2 01 1.”
BackgroundPicca, A., Saini, S. K., Mankowski, R. T., Kamenov, G. D., Anton, S. D., Manini, T. M., Buford, T. W., Wohlgemuth, S. E., Xiao, R., Calvani, R., et al. (2020) · Cells · doi:10.3390/cells9122579 · Cited by 31
Self-citationPicca, A., Lozanoska‐Ochser, B., Calvani, R., Coelho‐Júnior, H. J., Leewenburgh, C., & Marzetti, E. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112204 · Cited by 30
“…is characterized by cell’s growth arrest and the release of a set of molecules referred to as circulating senescence-associated secretory phenotype (SASP) factors, including interleukins (ILs), chemokines, growth factors, proteases, and components of the extracellular matrix (Coppé et al., 2010).”
BackgroundZhang, X., Kunz, H., Gries, K. J., Hart, C. R., Polley, E. C., & Lanza, I. R. (2021) · The Journal of Physiology · doi:10.1113/jp281691 · Cited by 31
“The Journal of Physiology © 2021 The Physiological Society oxidative capacity in older adults (Lanza et al. 2008; Coen et al. 2013).”
BackgroundResultTian, Q., Mitchell, B. A., Zampino, M., & Ferrucci, L. (2022) · GeroScience · doi:10.1007/s11357-022-00548-w · Cited by 28
“As instructed, participants performed a fast, intense, ballistic knee extension exercise designed to deplete PCr in the quadriceps muscles with minimal acidification, permitting assessment of maximal oxidative phosphorylation [5].”
MethodSelf-citationMau, T., Barnes, H. N., BLACKWELL, T. L., Kramer, P. A., Bauer, S. R., Marcinek, D. J., Ramos, S. V., Forman, D. E., Toledo, F. G. S., Hepple, R. T., et al. (2023) · GeroScience · doi:10.1007/s11357-023-01002-1 · Cited by 27
“Percutaneous muscle biopsy of vastus lateralis was performed as previously described [13, 31].”
Self-citationMild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle
Morris, J. K., McCoin, C. S., Fuller, K. N. Z., John, C. S., Wilkins, H., Green, Z. D., Wang, X., Sharma, P., Burns, J. M., Vidoni, E. D., et al. (2021) · Function · doi:10.1093/function/zqab045 · Cited by 26
Mitochondrial function in metabolic health: A genetic and environmental tug of war
Stephenson, E. J., & Hawley, J. A. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.12.004 · Cited by 28
Cefis, M., Marcangeli, V., Hammad, R., Granet, J., Leduc‐Gaudet, J., Gaudreau, P., Trumpff, C., Huang, Q., Picard, M. A., Aubertin‐Leheudre, M., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101968 · Cited by 26
“Since multiple previous studies have reported associations between mitochondrial respiration and parameters related to muscle mass, function, and physical performance, 12,25,31 we assessed whether such associations would be found in our cohort.”
Layec, G., Haseler, L. J., Trinity, J. D., Hart, C. R., Liu, X., Fur, Y. L., Jeong, E., & Richardson, R. S. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00257.2013 · Cited by 26
“Interestingly, as already acknowledged, there appears to be a proportionality between the peak rate of oxidative ATP synthesis estimated in vivo by (31)P-MRS and the maximal rate of O2 consumption measured in vitro in isolated mitochondria (31) and permeabilized fibers (7), both scenarios where O2 and substrates are i…”
AlGhatrif, M., Zane, A. C., Oberdier, M. T., Canepa, M., Studenski, S. A., Simonsick, E. M., Spencer, R. G. S., Fishbein, K. W., Reiter, D. A., Lakatta, E. G., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006604 · Cited by 26
“Participants performed a rapid ballistic knee extension exercise while lying supine in the bore of the magnet; this maneuver was practiced before entering the magnet.(11,12) A series of pulse-acquire 31P spectra were obtained before, during, and after the knee extension exercise.”
MethodSelf-citationPapadopoulos, E., Irving, B. A., Brown, J. C., Heymsfield, S. B., Sattar, S., Alibhai, S. M. H., Williams, G. R., & Dunne, R. F. (2025) · Drugs & Aging · doi:10.1007/s40266-025-01252-y · Cited by 28
“Moreover, the severity of age-related impairments in mitochondrial bioenergetic function has been associated with lower physical function [125, 126].”
Skeletal muscle cellular metabolism in older HIV-infected men
Ortmeyer, H. K., Ryan, A. S., Hafer‐Macko, C. E., & Oursler, K. K. (2016) · Physiological Reports · doi:10.14814/phy2.12794 · Cited by 26
“In older adults without HIV, increased age is associated with skeletal muscle mitochondrial dysfunction, which strongly correlates with low aerobic capacity (Short et al. 2005) and slower walking speed (Coen et al. 2013).”
BackgroundMasuki, S., Morita, A., Kamijo, Y., Ikegawa, S., Kataoka, Y., Ogawa, Y., Sumiyoshi, E., Takahashi, K., Tanaka, T., Nakajima, M., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00582.2015 · Cited by 24
“This is consistent with a recent study showing that higher muscle mitochondrial efficiency was associated with a faster preferred walking speed in older adults (9).”
ResultSummerside, E. M., Courter, R. J., Shadmehr, R., & Ahmed, A. A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1596-23.2024 · Cited by 24
Distéfano, G., Harrison, S. L., Lynch, J. A., Link, T. M., Kramer, P. A., Ramos, S. V., Mau, T., Coen, P. M., Sparks, L. M., Goodpaster, B. H., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42953 · Cited by 25
“17,18 In older adults, muscle mitochondrial energetics is associated with leg power, 19 physical performance, 20,21 and fati-gability.”
Self-citationEvaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods
Campbell, M. D., & Marcinek, D. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.019 · Cited by 25
Etiological Role of Aging in Chronic Diseases: From Epidemiological Evidence to the New Geroscience
Fried, L. P., & Ferrucci, L. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_2 · Cited by 25
Self-citationDodds, R. M., Davies, K., Granic, A., Hollingsworth, K. G., Warren, C., Gorman, G. S., Turnbull, D. M., & Sayer, A. A. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.09.020 · Cited by 24
“group, with relevant studies typically having a mean age below 85 (Coen et al., 2013; Choi et al., 2016; Spendiff et al., 2016; Rygiel et al., 2017; Distefano et al., 2017).”
BackgroundQuiriarte, H. D., Noland, R. C., Stampley, J., Davis, G., Li, Z., Cho, E., Kim, Y., Doiron, J. E., Spielmann, G., Ghosh, S. K., et al. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.07.009 · Cited by 24
Frailty Worsens Antidepressant Treatment Outcomes in Late Life Depression
Brown, P. J., Ciarleglio, A., Roose, S. P., Garcia, C. M., Chung, S., Alvarez, J., Stein, A., Gomez, S., & Rutherford, B. R. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.12.024 · Cited by 23
Picca, A., Triolo, M., Wohlgemuth, S. E., Martenson, M. S., Mankowski, R. T., Anton, S. D., Marzetti, E., Leeuwenburgh, C., & Hood, D. A. (2023) · Cells · doi:10.3390/cells12010183 · Cited by 23
Self-citationScalzo, R. L., Schauer, I. E., Rafferty, D., Knaub, L. A., Kvaratskhelia, N., Johnson, T. K., Pott, G. B., Abushamat, L. A., Whipple, M. O., Huebschmann, A. G., et al. (2021) · The Journal of Physiology · doi:10.1113/jp280603 · Cited by 24
“Oxidative flux is impaired in people with T2D (Cree-Green et al. 2017, 2018) and contributes to lower cardiorespiratory fitness in this population (Coen et al. 2013).”
BackgroundSkeletal muscle bioenergetics in aging and heart failure
Liu, S. Z., & Marcinek, D. J. (2016) · Heart Failure Reviews · doi:10.1007/s10741-016-9586-z · Cited by 25
“This relationship also extends to elderly populations where ATPmax was correlated with preferred walking speed [43] and greater self-reported fatigability [61].”
Pérez-Toro, P. A., Vásquez-Correa, J. C., Arias‐Vergara, T., Nöth, E., & Orozco‐Arroyave, J. R. (2020) · Nonlinear Dynamics · doi:10.1007/s11071-020-05691-7 · Cited by 22
Molecular mechanisms and potential interventions during aging-associated sarcopenia
Luo, X., Wang, J., Ju, Q., Li, T., & Bi, X. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.112020 · Cited by 23
The Mystery of Energy Compensation
Halsey, L. G. (2021) · Physiological and Biochemical Zoology · doi:10.1086/716467 · Cited by 22
“…increased mitochondrial performance (Fernström et al. 2004; Porter et al. 2015), and there is tentative evidence that older humans with a more sedentary lifestyle have a reduced walking capacity and speed relating to a lower mitochondrial efficiency (Coen et al. 2013; Distefano et al. 2018).”
BackgroundSkeletal Muscle Mitochondrial Adaptations to Maximal Strength Training in Older Adults
Berg, O. K., Kwon, O. S., Hureau, T. J., Clifton, H. L., Thurston, T. S., Fur, Y. L., Jeong, E., Trinity, J. D., Richardson, R. S., Wang, E., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa082 · Cited by 21
“However, the mechanistic basis for the age-related decrease in physical functional capacity is complex, with one leading hypothesis attributing the development of muscle weakness, not solely to diminished muscle mass, but to a primary defect in energy metabolism (2,3), due to mitochondrial dysfunction (4,5).”
BackgroundAlldritt, I., Greenhaff, P. L., & Wilkinson, D. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413575 · Cited by 21
“Taken alongside the association of lower mitochondrial efficiency and capacity with slower walking speeds reported in older adults [129], this suggests reduced mitochondrial function and/or capacity contributes to the sarcopenic phenotype.”
BackgroundMarcinek, D. J., & Ferrucci, L. (2024) · The Journal of Physiology · doi:10.1113/jp285040 · Cited by 20
“Skeletal muscle OxCap is also significantly associated with and predicts future declines of gait speed and mobility, even after adjusting for confounders such as muscle strength, sex and comorbidities (Coen et al., 2013; Tian et al., 2022).”
Self-citationAdar, O., Hollander, A., & Ilan, Y. (2023) · Advances in respiratory medicine · doi:10.3390/arm91050028 · Cited by 20
“Over time, mitochondria produce ATP at different rates in different subjects, populations, and environments within the same individual [64–67].”
BackgroundYoshiko, A., Shiozawa, K., Niwa, S., Takahashi, H., Koike, T., Watanabe, K., Katayama, K., & Akima, H. (2023) · GeroScience · doi:10.1007/s11357-023-01043-6 · Cited by 20
“Besides, skeletal muscle oxidative capacity is associated with muscle strength and exercise performance [4, 5, 10].”
Walking economy at simulated high altitude in human healthy young male lowlanders
Horiuchi, M., Handa, Y., Abe, D., & Fukuoka, Y. (2016) · Biology Open · doi:10.1242/bio.019810 · Cited by 16
“Additionally, preferred walking speed, which was found to be almost consistent with ES in previous studies (Malatesta et al., 2003; Wezenberg et al., 2013), has been suggested to be related to peak aerobic capacity and muscle mitochondrial capacity (Coen et al., 2013).”
BackgroundResultTetri, L. H., Diffee, G. M., Barton, G. P., Braun, R., Yoder, H. E., Haraldsdóttir, K., Eldridge, M. W., & Goss, K. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00326 · Cited by 20
“Mitochondrial respiratory capacity has been observed to correlated with walking speed, muscular VO2 and whole body VO2 in untrained individuals (Coen et al., 2013; Gifford et al., 2016).”
BackgroundXu, X., & Wen, Z. (2023) · PubMed Central · Cited by 21
Calf raise exercise increases walking performance in patients with intermittent claudication
van Schaardenburgh, M., Wohlwend, M., Rognmo, Ø., & Mattsson, E. J. R. (2017) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.12.106 · Cited by 19
Karavirta, L., Rantalainen, T., Skantz, H., Lisko, I., Portegijs, E., & Rantanen, T. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa142 · Cited by 19
Toledo, F. G. S., Dubé, J. J., Goodpaster, B. H., Stefanović-Račić, M., Coen, P. M., & DeLany, J. P. (2018) · Obesity · doi:10.1002/oby.22163 · Cited by 19
“Another parameter that we explored was the mitochondrial oxidative capacity of skeletal muscle, which has previously been shown to be highly correlated with VO2max (18,19,28,29).”
Self-citationAdamson, S., Kavaliauskas, M., Lorimer, R., & Babraj, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17020454 · Cited by 18
“Greater aerobic capacity in older adults has been associated with greater physical function and may, to some extent, explain the improved performance in functional tests [29].”
BackgroundFitzgerald, L. F., Bartlett, M. F., & Kent, J. A. (2023) · Physiological Reports · doi:10.14814/phy2.15876 · Cited by 18
“Because mitochondrial energetics are closely associated with maximal aerobic capacity and walking speed in older adults (Coen et al., 2013), future studies should elucidate the specific participant characteristics that are associated with lower muscle oxidative capacity with age.”
BackgroundQiao, Y., Blackwell, T., Cawthon, P. M., Coen, P. M., Cummings, S. R., Distéfano, G., Farsijani, S., Forman, D. E., Goodpaster, B. H., Kritchevsky, S. B., et al. (2024) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2024.02.001 · Cited by 21
“4,8 Further, there might be potential residual confounding given the complex biological pathways linking PA and skeletal muscle energetics.”
Self-citationAoki, K., Konno, M., Honda, K., Abe, T., Nagata, T., Takehara, M., Sugasawa, T., Takekoshi, K., & Ohmori, H. (2020) · Geriatrics · doi:10.3390/geriatrics5030048 · Cited by 18
“Reduced mitochondrial activity results in reduced ATP synthesis in muscle cells and overall muscle weakness [16,17], for which aerobic exercise has been demonstrated to have a positive effect.”
BackgroundGrootswagers, P., Smeets, E. T. H. C., Oteng, A., & de Groot, C. P. G. M. (2021) · Aging · doi:10.18632/aging.202912 · Cited by 19
“phosphorylation correlates well with walking speed in studies with comparable populations [42, 43].”
ResultRaman spectroscopy as a tool for detecting mitochondrial fitness
Erjavec, N., Pinato, G., & Ramser, K. (2016) · Journal of Raman Spectroscopy · doi:10.1002/jrs.4930 · Cited by 17
Brown, P. J., Brennan, N. A., Ciarleglio, A., Chen, C., Garcia, C. M., Gomez, S., Roose, S. P., Rutherford, B. R., Simonsick, E. M., Spencer, R. G. S., et al. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.03.022 · Cited by 17
Self-citationLiu, F., Wanigatunga, A. A., Zampino, M., Knuth, N. D., Simonsick, E. M., Schrack, J. A., & Ferrucci, L. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa201 · Cited by 17
Self-citationMetabolites Associated with Memory and Gait: A Systematic Review
Tian, Q., Mitchell, B. A., Corkum, A. E., Moaddel, R., & Ferrucci, L. (2022) · Metabolites · doi:10.3390/metabo12040356 · Cited by 17
Self-citationKumari, S., Bubak, M. P., Schoenberg, H. M., Davidyan, A., Elliehausen, C. J., Kuhn, K. G., VanWagoner, T. M., Karaman, R., Scofield, R. H., Miller, B. F., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab358 · Cited by 20
Qiao, Y., Santanasto, A. J., Coen, P. M., Cawthon, P. M., Cummings, S. R., Forman, D. E., Goodpaster, B. H., Harezlak, J., Hawkins, M., Kritchevsky, S. B., et al. (2023) · Aging Cell · doi:10.1111/acel.14015 · Cited by 16
“This is a functional measure of in vivo ATP production via oxidative phosphorylation (Coen et al., 2013 ).”
BackgroundMethodResultInfluentialSelf-citationMau, T., Blackwell, T., Cawthon, P. M., Molina, A. J. A., Coen, P. M., Distéfano, G., Kramer, P. A., Ramos, S. V., Forman, D. E., Goodpaster, B. H., et al. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae101 · Cited by 17
Self-citationSalin, K., Mathieu‐Resuge, M., Graziano, N., Dubillot, E., Grand, F. L., Soudant, P., & Vagner, M. (2020) · Marine Environmental Research · doi:10.1016/j.marenvres.2020.105205 · Cited by 17
Impact of age on exercise-induced ATP supply during supramaximal plantar flexion in humans
Layec, G., Trinity, J. D., Hart, C. R., Kim, S., Haseler, L. J., Fur, Y. L., Sorensen, J. R., Jeong, E., & Richardson, R. S. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00522.2014 · Cited by 18
“Despite these limitations, the suggestion in this study (15) that mitochondrial dysfunction can contribute to a reduction in muscle efficiency should not be ruled out, since these two mechanisms (contractile and/or mitochondrial inefficiency) are not mutually exclusive and, in fact, may both explain the increase in th…”
BackgroundTian, Q., Greig, E. E., Walker, K. A., Fishbein, K. W., Spencer, R. G. S., Resnick, S. M., & Ferrucci, L. (2024) · Age and Ageing · doi:10.1093/ageing/afae079 · Cited by 15
Self-citationChen, S., He, T., Chen, J., Wen, D., Wang, C., Huang, W., Yang, Z., Yang, M., Li, M., Huang, S., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13558 · Cited by 15
“The loss of Yy1 resulted in an increase in fat mass percentage and impaired exercise ability (Figure 6).”
BackgroundAn Ecologist’s Guide to Mitochondrial DNA Mutations and Senescence
Hood, W. R., Williams, A. S., & Hill, G. E. (2019) · Integrative and Comparative Biology · doi:10.1093/icb/icz097 · Cited by 15
Acute resveratrol supplementation in coronary artery disease: towards patient stratification
Diaz, M., Ávila, A., Degens, H., Coeckelberghs, E., Vanhees, L., Cornelissen, V., & Azzawi, M. (2019) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2019.1657584 · Cited by 15
A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function
Zampino, M., Tanaka, T., Ubaida‐Mohien, C., Fantoni, G., Candia, J., Semba, R. D., & Ferrucci, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249540 · Cited by 15
“Phosphorus Magnetic Resonance Spectroscopy Using a 3T MR scanner (Achieva, Philips Healthcare, Andover, MA, USA), in vivo 31P-MRS measurements of the concentrations of the phosphorus-containing metabolites phosphocreatine (PCr), inorganic phosphate (Pi), and ATP were obtained from the vastus lateralis muscle of the le…”
MethodSelf-citationElliehausen, C. J., Minton, D. M., Nichol, A. D., & Konopka, A. R. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111579 · Cited by 16
Tian, Q., Moore, A. Z., Oppong, R., Ding, J., Zampino, M., Fishbein, K. W., Spencer, R. G. S., & Ferrucci, L. (2021) · Aging Cell · doi:10.1111/acel.13487 · Cited by 12
Self-citationStephenson, M. C., Ho, J. X. M., Migliavacca, E., Kalimeri, M., Karnani, N., Banerji, S., Totman, J. J., Feige, J. N., Merchant, R. A., & Tay, S. K. H. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13220 · Cited by 15
Point: Skeletal muscle mechanical efficiency does increase with age
Venturelli, M., & Richardson, R. S. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01438.2012 · Cited by 16
Mitochondrial Dysfunction and Intrinsic Capacity: Insights From a Narrative Review
da Silva, J. A., Rolland, Y., Martinez, L. O., & Barreto, P. D. S. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac227 · Cited by 14
Wesson, D. E., Mathur, V. S., & Tangri, N. (2022) · American Journal of Nephrology · doi:10.1159/000526679 · Cited by 14
Franczak, E., Maurer, A., Csikós, V., Kugler, B. A., Wells, E., Wenger, M., Peelor, F. F., Crosswhite, A., McCoin, C. S., Koch, L. G., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00985-1 · Cited by 13
“Aerobic capacity and physical activity status are known to increase markers of mitochondrial content and oxidative metabolism in humans [53, 54], and in rodent models [23].”
Jacob, K. J., Sonjak, V., Spendiff, S., Hepple, R. T., Chevalier, S., Pérez, A., & Morais, J. A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.619216 · Cited by 13
“They can also present with increased susceptibility to apoptosis via decreased CRC and/or mPTP opening, which may ultimately lead to fiber atrophy and hampered muscle performance (11, 12).”
BackgroundBittel, D. C., Bittel, A. J., Varadhachary, A. S., Pietka, T., & Sinacore, D. R. (2021) · Diabetes · doi:10.2337/db20-0688 · Cited by 12
Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP
Asthana, P., & Wong, H. L. X. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167081 · Cited by 13
Reduced oxidative capacity of skeletal muscle IS NOT an inevitable consequence of adult ageing
Lanza, I. R., Sundberg, C. W., & Kent, J. A. (2024) · The Journal of Physiology · doi:10.1113/jp285042 · Cited by 13
“Consequently, an increasing number of laboratories have adopted the permeabilized fibre preparation as a more physiological alternative to the conventional isolated mitochondria approach for studying ageing human skeletal muscle (Coen et al., 2013; Distefano et al., 2017).”
Reproducibility of NIRS-derived mitochondrial oxidative capacity in highly active older adults
Fennell, C. R. J., Mauger, A. R., & Hopker, J. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112156 · Cited by 14
Wong, T.-C., Chen, Y.-T., Wu, P.-Y., Chen, T.-W., Chen, H.-H., Chen, T.-H., Hsu, Y., & Yang, S. (2016) · Nutrition · doi:10.1016/j.nut.2016.02.015 · Cited by 12
Cummings, S. R., Lui, L., Glynn, N. W., Mau, T., Cawthon, P. M., Kritchevsky, S. B., Coen, P. M., Goodpaster, B., Marcinek, D. J., Hepple, R. T., et al. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18763 · Cited by 12
“22,25 The energy required to walk at one's usual pace increases with aging after the seventh decade and has been associated with slow gait speed over short distances, for example, 6 m. 26 Few other potential correlates of gait speed have been studied.”
BackgroundSelf-citationMonferrer-Marín, J., Roldán, A., Monteagudo, P., Chulvi‐Medrano, I., & Blasco-Lafarga, C. (2022) · Sports Medicine - Open · doi:10.1186/s40798-022-00487-y · Cited by 12
Kojima, S., Usui, N., Uehata, A., Hisadome, H., Inatsu, A., Tsuchiya, T., Mawatari, T., & Tsubaki, A. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14681 · Cited by 10
“28 In addition, low physical activity in patients undergoing HD has been associated not only with a decline in peakVO 214 but also anxiety and depression.”
BackgroundMuscle fatigability and depressive symptoms in later life
Brown, P. J., Badreddine, D., Roose, S. P., Rutherford, B. R., Ayonayon, H. N., Yaffe, K. S., Simonsick, E. M., Goodpaster, B. H., & Study, F. T. H. A. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4678 · Cited by 13
“Two potential mechanisms of fatigability in later life have recently been discussed as potential biological markers for the identification of high-risk endophenotypes of LLD: mitochondrial dysfunction and elevated inflammatory cytokines.”
BackgroundResultInfluentialSelf-citation
Metadata
- Authors
- Coen, P. M., Jubrias, S. A., Distefano, G., Amati, F., Mackey, D. C., Glynn, N. W., Manini, T. M., Wohlgemuth, S. E., Leeuwenburgh, C., Cummings, S. R., Newman, A. B., Ferrucci, L., Toledo, F. G. S., Shankland, E., Conley, K. E., & Goodpaster, B. H.
- Affiliations
- University of Pittsburgh (US)
- University of Washington Medical Center (US)
- California Pacific Medical Center (US)
- University of Florida (US)
- National Institute on Aging (US)
- ORCID
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10-09
- Volume
- 68
- Issue
- 4
- Pages
- 447-455
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC3593613
- OpenAlex
- W2115546051
- Cited by
- 323
- References
- 42
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 40 · 2023: 30 · 2022: 20 · 2021: 43 · 2020: 26 · 2019: 20 · 2018: 14 · 2017: 19 · 2016: 34 · 2015: 16 · 2014: 14 · 2013: 8 · 2012: 1
- FWCI
- 30.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of Pittsburgh (P30-AG024827, UL1RR024153, RR024153)
- National Institutes of Health (UL1TR000005)
- National Institute on Aging (RC2AG036594, RC2AG036606, P30AG024827, P30AG028740)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR 41928, R01AR041928)
- National Center for Research Resources (RR-024153, UL1RR024153)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- skeletal muscle mitochondria, mitochondrial respiration, maximal aerobic capacity, peak oxygen uptake, walking speed, older adults, mitochondrial efficiency, oxidative capacity, vastus lateralis, aging
- MeSH terms
- Age Factors, Aged, Biopsy, Energy Metabolism, Postural Balance, Female, Humans, Male, Mitochondria, Muscle, Muscle Contraction, Oxygen Consumption, Physical Endurance, Physical Fitness, Walking, Muscle, Skeletal, Quadriceps Muscle
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
