Bed Rest Promotes Reductions in Walking Speed, Functional Parameters, and Aerobic Fitness in Older, Healthy Adults
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CONTEXT: The exact relationship between the bed rest-induced loss of skeletal muscle and reductions in muscle strength and physical performance in the older individuals is still unclear. OBJECTIVE: We examined the effect of 10 days of bed rest on changes in regional body composition, muscle strength, and functional status, and the relationship between these variables in older individuals. DESIGN, PARTICIPANTS, AND INTERVENTION: Regional body composition was measured using dual energy x-ray absorptiometry. We also determined changes in leg strength and several indices of functional status, including walking speed. RESULTS: Body weight, body mass index, and total and lower extremity lean mass decreased with bed rest. There were also significant reductions in knee extension one repetition maximum, isometric knee extension, knee extension 60° concentric, stair ascent time, stair ascent power, stair descent time, VO2 max, floor transfer test, 5-minute walk time, and chair stand. The overall change in total and lower extremity lean mass was also directly related to bed rest-induced reductions in one repetition maximum knee extension. CONCLUSIONS: Bed rest promoted overall declines in muscle mass, muscle strength, and physical function in older individuals. The changes in lean tissue were closely correlated with the bed rest-induced decline of muscle strength.
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Bed rest has a substantial impact on muscle function, established in a decline in performance.
“Moreover, bed rest has a substantial impact on muscle function established in a decline in performance (9, 10).”
From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [9]
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References 34 · Cited by 174
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- Authors
- Coker, R. H., Hays, N. P., Williams, R. H., Wolfe, R. R., & Evans, W. J.
- Affiliations
- University of Alaska Fairbanks (US)
- University of Arkansas for Medical Sciences (US)
- KineMed (United States) (US)
- Corresponding author
- Coker, R. H.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-08-13
- Volume
- 70
- Issue
- 1
- Pages
- 91-96
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC4342684
- OpenAlex
- W2055982145
- Cited by
- 174
- References
- 34
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 13 · 2023: 11 · 2022: 17 · 2021: 26 · 2020: 21 · 2019: 18 · 2018: 9 · 2017: 13 · 2016: 11 · 2015: 8 · 2014: 2
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG023591)
- National Institute of Diabetes and Digestive and Kidney Diseases (KO1 DK 64716-01, K01DK064716)
- National Center for Research Resources (M01 RR 14288, M01RR014288)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- bed rest, sarcopenia, muscle strength, functional status, walking speed, cardiorespiratory fitness, lean body mass, body composition, older adults, muscle mass loss, physical performance, quadriceps strength
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Aging, Bed Rest, Body Composition, Female, Humans, Male, Middle Aged, Physical Fitness, Exercise, Walking, Muscle, Skeletal, Muscle Strength
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